Explore top 2026 4 Star Hotels in Central San Diego

Name: Hyatt Regency La Jolla
Price range: $276 total
Rating: 9

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Top Central San Diego 4 Star hotels

Town and Country San Diego

500 Hotel Circle North San Diego CA

$233 nightly

$268 total

Nov 10 - Nov 11

Total with taxes and fees

This hotel features 2 restaurants, 2 outdoor pools, and a hot tub. Bring the family and enjoy the children's pool, waterslide, and playground. Enjoy the gym ...

8.6/10 Excellent! (1,987 reviews)

"My original room smelled and didn’t have windows that opened. I was upgraded to a room with a balcony which was great. There was only one working elevator in the building for staff and guests, which was leaking rain water from above and made concerning noises while in operation. The shared walkway ..."

Reviewed on Oct 11, 2026

Lafayette Hotel & Club

2223 El Cajon Blvd San Diego CA

Fully refundableReserve now, pay when you stay

$273 nightly

$314 total

Oct 19 - Oct 20

Total with taxes and fees

This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...

DoubleTree by Hilton Hotel San Diego - Mission Valley

7450 Hazard Center Dr San Diego CA

Fully refundableReserve now, pay when you stay

$144 nightly

$165 total

Nov 8 - Nov 9

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 20 conference rooms, free WiFi in public areas, ...

8.4/10 Very Good! (1,849 reviews)

"Clean room"

Reviewed on Oct 10, 2026

San Diego Marriott La Jolla

4240 La Jolla Village Dr La Jolla CA

Fully refundableReserve now, pay when you stay

$184 nightly

$212 total

Oct 24 - Oct 25

Total with taxes and fees

This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.6/10 Excellent! (2,525 reviews)

"Great property, easy to stay at, close to I5."

Reviewed on Oct 11, 2026

Hilton San Diego Mission Valley

901 Camino Del Rio S San Diego CA

Fully refundableReserve now, pay when you stay

$139 nightly

$159 total

Oct 20 - Oct 21

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

Embassy Suites by Hilton San Diego La Jolla

4550 La Jolla Village Dr San Diego CA

Fully refundableReserve now, pay when you stay

$202 nightly

$233 total

Oct 30 - Oct 31

Total with taxes and fees

This traditional hotel includes 2 restaurants, an indoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and WiFi in ...

8.8/10 Excellent! (2,096 reviews)

"Great time"

Reviewed on Oct 11, 2026

Legacy Resort Hotel & Spa

875 Hotel Circle South San Diego CA

Fully refundableReserve now, pay when you stay

$174 nightly

$200 total

Oct 26 - Oct 27

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

DoubleTree by Hilton San Diego - Hotel Circle

1515 Hotel Cir S San Diego CA

Fully refundableReserve now, pay when you stay

$130 nightly

$150 total

Oct 15 - Oct 16

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

San Diego Marriott Mission Valley

8757 Rio San Diego Dr San Diego CA

Fully refundableReserve now, pay when you stay

$159 nightly

$183 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 30 conference rooms, business center, and express ...

8.8/10 Excellent! (1,002 reviews)

"Where do I start with this property. Firstly it is listed on expedia as a 4 star property (when I brought this up with the front desk, they literally laughed and said they are not). The first room we were assigned, had torn/ragged blinds and my husband found someone’s sock behind the chair. We would ..."

Reviewed on Oct 8, 2026

Hyatt Regency La Jolla

3777 La Jolla Village Drive San Diego CA

Fully refundableReserve now, pay when you stay

$240 nightly

$276 total

Nov 1 - Nov 2

Total with taxes and fees

2 outdoor tennis courts, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9/10 Wonderful! (1,004 reviews)

"A very short but pleasant stay. The complimentary a la carte breakfast was wonderful and the rooms were well appointed and comfortable. It was useful to have a convenience store in the lobby. Didn't get a chance to explore the hotel as I was only there for a few hours overnight on business."

Reviewed on Oct 11, 2026

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4 Star Hotels Central San Diego

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Central San Diego 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Central San Diego will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Central San Diego, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.