Explore top 2026 4 Star Hotels in Mission Valley

Name: Marriott Marquis San Diego Marina
Price range: $389 total

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Top Mission Valley 4 Star hotels

Manchester Grand Hyatt San Diego

1 Market Pl San Diego CA

Fully refundableReserve now, pay when you stay

$267 nightly

$310 total

Sep 27 - Sep 28

Total with taxes and fees

This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...

Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA

Fully refundableReserve now, pay when you stay

$182 nightly

$211 total

Sep 20 - Sep 21

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...

8.4/10 Very Good! (6,310 reviews)

"Here for a vacation and this spot was fantastic. Such a great central location. Perfect for walking to Little Italy or even the Gas Lamp. Even a decent walk to the zoo. Beautiful views of the harbor and easy access to the Coronado shuttle"

Reviewed on Sep 11, 2026

Hard Rock Hotel San Diego

207 5th Ave San Diego CA

Fully refundableReserve now, pay when you stay

$237 nightly

$274 total

Sep 13 - Sep 14

Total with taxes and fees

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...

Omni San Diego Hotel at the Ballpark

675 L St San Diego CA

Fully refundableReserve now, pay when you stay

$222 nightly

$258 total

Sep 13 - Sep 14

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (2,396 reviews)

"We really liked the proximity to the sights of san diego. The restaurants and bar were great at the hotel. Felt like a true getaway."

Reviewed on Sep 12, 2026

Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA

Fully refundableReserve now, pay when you stay

$254 nightly

$292 total

Oct 4 - Oct 5

Total with taxes and fees

This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...

8.8/10 Excellent! (2,856 reviews)

"Great place for families, endless activities for the kids and adults. Highly recommended!"

Reviewed on Sep 11, 2026

Sheraton San Diego Resort

1380 Harbor Island Dr San Diego CA

Fully refundableReserve now, pay when you stay

$213 nightly

$245 total

Sep 27 - Sep 28

Total with taxes and fees

A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...

Town and Country San Diego

500 Hotel Circle North San Diego CA

Fully refundableReserve now, pay when you stay

$231 nightly

$265 total

Sep 18 - Sep 19

Total with taxes and fees

This hotel features 2 restaurants, 2 outdoor pools, and a hot tub. Bring the family and enjoy the children's pool, waterslide, and playground. Enjoy the gym ...

Lafayette Hotel & Club

2223 El Cajon Blvd San Diego CA

Fully refundableReserve now, pay when you stay

$249 nightly

$286 total

Sep 30 - Oct 1

Total with taxes and fees

This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...

San Diego Mission Bay Resort

1775 E Mission Bay Dr San Diego CA

Fully refundableReserve now, pay when you stay

$286 nightly

$342 total

Oct 12 - Oct 13

Total with taxes and fees

A full-service spa, 2 restaurants, and 5 outdoor tennis courts are all featured at this Mediterranean resort. There's fun for all ages with a children's pool ...

Marriott Marquis San Diego Marina

333 W Harbor Dr San Diego CA

Fully refundableReserve now, pay when you stay

$336 nightly

$389 total

Sep 13 - Sep 14

Total with taxes and fees

A marina, 5 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Bring the family and enjoy the children's pool and kid-friendly dining. ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Mission Valley hotel reviews by fellow wanderers

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

4 out of 5

Posted 1 hour ago

Travelocity Verified Review

"The staff was wonderful and helpful. I did have to have my room cleaned again however they were on it with no bad attitude. Outdoor pool was great. Breakfast was great, but mostly I would come back just for the staff."

A verified traveler stayed at Best Western Inn & Suites San Diego – Zoo/SeaWorld Area