Explore top 2026 4 Star Hotels in South San Diego

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Top South San Diego 4 Star hotels

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
8.6/10 Excellent! (3,805 reviews)
"The hotel was nice staff lax in helping customers. You have to pay fifty bucks to park there. Even if your staying at the hotel. Locations, really nice hotel's nice. But staff and parking sucks. I gave this place a six out of ten."

Reviewed on Nov 2, 2026

Opens in a new windowSheraton San Diego Resort
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $269 total per night from Nov 29 to Nov 30
$269 total
Nov 29 - Nov 30
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
Opens in a new windowParadise Point Resort & Spa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
8.4/10 Very Good! (6,371 reviews)
"Wait line for check in was an hr. There was a long line for elevator as only one was working. Stairs are for emergency only so we had to wait a long time to get to our room after waiting a long time to check in. Once in an elevator it stopped on the second floor and wouldn’t go up, my room was on ..."

Reviewed on Nov 2, 2026

Opens in a new windowWyndham San Diego Bayside
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...
9/10 Wonderful! (4,580 reviews)
"Good"

Reviewed on Nov 2, 2026

Opens in a new windowHard Rock Hotel San Diego
Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla

4 out of 5
4550 La Jolla Village Dr San Diego CA
Fully refundableReserve now, pay when you stay
$191 nightly
The price is $220 total per night from Nov 22 to Nov 23
$220 total
Nov 22 - Nov 23
Total with taxes and fees
This traditional hotel includes 2 restaurants, an indoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and WiFi in ...
Opens in a new windowEmbassy Suites by Hilton San Diego La Jolla
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4 out of 5
1500 Orange Ave Coronado CA
Fully refundableReserve now, pay when you stay
$533 nightly
The price is $592 total per night from Nov 29 to Nov 30
$592 total
Nov 29 - Nov 30
Total with taxes and fees
A private beach, 6 restaurants, and an outdoor pool are all featured at this Victorian resort. Relax with sun loungers and beach umbrellas, and cool off with ...
Opens in a new windowHotel del Coronado, Curio Collection by Hilton
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$246 nightly
The price is $285 total per night from Nov 24 to Nov 25
$285 total
Nov 24 - Nov 25
Total with taxes and fees
This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
9/10 Wonderful! (2,892 reviews)
"Na"

Reviewed on Nov 2, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$265 nightly
The price is $305 total per night from Dec 1 to Dec 2
$305 total
Dec 1 - Dec 2
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
Opens in a new windowLafayette Hotel & Club
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd San Diego CA
Fully refundableReserve now, pay when you stay
$217 nightly
The price is $249 total per night from Nov 18 to Nov 19
$249 total
Nov 18 - Nov 19
Total with taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
Opens in a new windowHyatt Regency Mission Bay Spa and Marina
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr San Diego CA
Fully refundableReserve now, pay when you stay
$281 nightly
The price is $326 total per night from Nov 24 to Nov 25
$326 total
Nov 24 - Nov 25
Total with taxes and fees
A marina, 5 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Bring the family and enjoy the children's pool and kid-friendly dining. ...
Opens in a new windowMarriott Marquis San Diego Marina
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4 Star Hotels South San Diego

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in South San Diego 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in South San Diego will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in South San Diego, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent South San Diego hotel reviews by fellow wanderers

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