Book Hotels in South San Diego, CA

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Top South San Diego hotels

The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$186 nightly
The price is $213 total per night from Sep 28 to Sep 29
$213 total
Sep 28 - Sep 29
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
"Great stay with beautiful grounds. Amazing view from the room. Would recommend and will definitely stay there again!"

Reviewed on Sep 3, 2026

Opens in a new windowThe Dana on Mission Bay
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $208 total per night from Sep 28 to Sep 29
$208 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"Historic hotel, so the room was a tad bit smaller than other hotels. But the bed was comfortable, the room was clean and the bathroom was updated. The lobby was very welcoming and the location served me perfectly. I was pleasantly impressed with my three night stay here."

Reviewed on Sep 4, 2026

Opens in a new windowThe Sofia Hotel
California Suites Hotel

California Suites Hotel

2 out of 5
5415 Clairemont Mesa Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $102 total per night from Sep 20 to Sep 21
$102 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an outdoor pool and a hot tub. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference ...
"I was happy about my choice."

Reviewed on Sep 4, 2026

Opens in a new windowCalifornia Suites Hotel
Gaylord Pacific Resort & Convention Center

Gaylord Pacific Resort & Convention Center

4 out of 5
1000 H Street Chula Vista CA
Fully refundableReserve now, pay when you stay
$314 nightly
The price is $363 total per night from Sep 7 to Sep 8
$363 total
Sep 7 - Sep 8
Total with taxes and fees
A full-service spa, 8 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Opens in a new windowGaylord Pacific Resort & Convention Center
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$246 nightly
The price is $285 total per night from Sep 7 to Sep 8
$285 total
Sep 7 - Sep 8
Total with taxes and fees
This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
Opens in a new windowManchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $292 total per night from Sep 7 to Sep 8
$292 total
Sep 7 - Sep 8
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
Opens in a new windowParadise Point Resort & Spa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Sep 7 to Sep 8
$211 total
Sep 7 - Sep 8
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
Opens in a new windowWyndham San Diego Bayside
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $277 total per night from Sep 7 to Sep 8
$277 total
Sep 7 - Sep 8
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...
Opens in a new windowHard Rock Hotel San Diego
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$111 nightly
The price is $128 total per night from Sep 7 to Sep 8
$128 total
Sep 7 - Sep 8
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Opens in a new windowHandlery Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap South San Diego hotels

The Rambler Hotel

The Rambler Hotel

225 Bay Blvd Chula Vista CA
$107 nightly
The price is $132 total per night from Oct 4 to Oct 5
$132 total
Oct 4 - Oct 5
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent South San Diego hotel reviews by fellow wanderers

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Staff was very helpful and attentive"
A verified traveler stayed at Sheraton San Diego Resort
Sheraton San Diego Resort

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