Book Hotels in South San Diego, CA

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Top South San Diego hotels

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
$244 nightly
The price is $283 total per night from Jul 27 to Jul 28
$283 total
Jul 27 - Jul 28
Total includes taxes and fees
This eco-certified hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi ...
"Outstanding"

Reviewed on Jul 24, 2025

Manchester Grand Hyatt San Diego
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
$272 nightly
The price is $315 total per night from Aug 17 to Aug 18
$315 total
Aug 17 - Aug 18
Total includes taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 5 restaurants. Families will appreciate the children's pool and onsite laundry facilities. Enjoy ...
"Best place to stay in 💯"

Reviewed on Jul 24, 2025

Marriott Marquis San Diego Marina
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $190 total per night from Aug 25 to Aug 26
$190 total
Aug 25 - Aug 26
Total includes taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
"Nice"

Reviewed on Jul 23, 2025

The Dana on Mission Bay
Hilton San Diego Bayfront

Hilton San Diego Bayfront

4 out of 5
1 Park Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
$244 nightly
The price is $282 total per night from Aug 14 to Aug 15
$282 total
Aug 14 - Aug 15
Total includes taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Bring the family and enjoy the children's pool and kid-friendly dining. ...
"The staff was professional and polite."

Reviewed on Jul 25, 2025

Hilton San Diego Bayfront
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $195 total per night from Jul 27 to Jul 28
$195 total
Jul 27 - Jul 28
Total includes taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, express check-out, and ...
"Great location and the staff were all friendly and helpful. Definitely needs some attention to the room though. Drapes were torn and tattered. But I would stay again."

Reviewed on Jul 23, 2025

Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Aug 10 to Aug 11
$128 total
Aug 10 - Aug 11
Total includes taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"The best part of this place was the fabulous pool. The staff was helpful and pleasant. The room was adequate, but it could use a facelift. Wall paper was warped towards the floor and our sliding door was stuck. Air conditioning worked very well, and the beds were comfortable. I will stay here again. ..."

Reviewed on Jul 23, 2025

Handlery Hotel
Gaylord Pacific Resort & Convention Center

Gaylord Pacific Resort & Convention Center

4 out of 5
1000 H Street, Chula Vista, CA
Fully refundableReserve now, pay when you stay
$345 nightly
The price is $401 total per night from Aug 26 to Aug 27
$401 total
Aug 26 - Aug 27
Total includes taxes and fees
A full-service spa, 8 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
"Great property with fantastic staff!"

Reviewed on Jul 24, 2025

Gaylord Pacific Resort & Convention Center
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
Fully refundable
$139 nightly
The price is $158 total per night from Aug 10 to Aug 11
$158 total
Aug 10 - Aug 11
Total includes taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"This hotel is in an industrial area, pretty remote. Our room had no towels and TVremote was not working. AC worked great."

Reviewed on Jul 24, 2025

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $157 total per night from Aug 3 to Aug 4
$157 total
Aug 3 - Aug 4
Total includes taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Hotel and staff are terrific, but no microwave in the room and none available for guests to use. If you eat out, don't bring home any leftovers, can't warm them up!"

Reviewed on Jul 25, 2025

The Dextro Hotel, BW Premier Collection
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap South San Diego hotels

The Rambler Motel

The Rambler Motel

225 Bay Blvd, Chula Vista, CA
$118 nightly
The price is $136 total per night from Aug 3 to Aug 4
$136 total
Aug 3 - Aug 4
Total includes taxes and fees
9/10 Wonderful! (1,883 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent South San Diego hotel reviews by fellow wanderers

The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

5 out of 5
Posted 16 hours ago
Travelocity Verified Review
"Easy check-in, clean room. Staff and manager were kind and accommodating on a very busy comic-con weekend. Would definitely stay here again. "
A verified traveler stayed at The Dextro Hotel, BW Premier Collection
The Dextro Hotel, BW Premier Collection
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