Book Hotels in South San Diego, CA

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Feb 8 - Feb 9
Tomorrow
Feb 9 - Feb 10
Next weekend
Feb 13 - Feb 15
In two weeks
Feb 20 - Feb 22

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top South San Diego hotels

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St San Diego CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $155 total per night from Feb 16 to Feb 17
$155 total
Feb 16 - Feb 17
Total with taxes and fees
This hotel features an outdoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the hot tub and free buffet breakfast ...
Great

Reviewed on Feb 2, 2026

Opens in a new windowHampton Inn & Suites by Hilton San Diego SeaWorld
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from Feb 16 to Feb 17
$160 total
Feb 16 - Feb 17
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Our room was large, well appointed, and had a nice balcony. Located on Shelter Island, it was an easy drive to downtown, and up North along the coast. There's good food, snack, and drinks also within a short drive. Dining and music are within walkable distance. Our room was clean and all appliance ...

Reviewed on Feb 7, 2026

Opens in a new windowBay Club Hotel & Marina
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$266 nightly
The price is $308 total per night from Feb 12 to Feb 13
$308 total
Feb 12 - Feb 13
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
Very clean hotel. I was always seeing someone cleaning.

Reviewed on Feb 2, 2026

Opens in a new windowHard Rock Hotel San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $135 total per night from Feb 22 to Feb 23
$135 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Very clean, comfy and spacious room. The staff was friendly and the location was good, if you’re looking to be close to Little Italy restaurants.

Reviewed on Feb 3, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $212 total per night from Feb 22 to Feb 23
$212 total
Feb 22 - Feb 23
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
Clean rooms, but small. Good pools and amenities. Had to pay additional parking and resort fee.

Reviewed on Feb 7, 2026

Opens in a new windowThe Dana on Mission Bay
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$198 nightly
The price is $227 total per night from Mar 1 to Mar 2
$227 total
Mar 1 - Mar 2
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
The staff were absolutely incredible!! We loved the hotel, restaurants and amenities!

Reviewed on Feb 7, 2026

Opens in a new windowParadise Point Resort & Spa
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $167 total per night from Mar 8 to Mar 9
$167 total
Mar 8 - Mar 9
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Rooms were clean, the beds were soo comfy, and staff was nice.

Reviewed on Feb 3, 2026

Opens in a new windowThe Sofia Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Feb 15 to Feb 16
$211 total
Feb 15 - Feb 16
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
This hotel is at a perfect location close to everything. Everyone is so nice and helpful.

Reviewed on Feb 7, 2026

Opens in a new windowWyndham San Diego Bayside
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $92 total per night from Feb 10 to Feb 11
$92 total
Feb 10 - Feb 11
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
The room was great. It was just for a couple hours because we were working in San Diego but thank you very much for the good comfort and the cleanliness

Reviewed on Feb 5, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Don't see what you're looking for?
See all available properties in South San Diego
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap South San Diego hotels

The Rambler

The Rambler

225 Bay Blvd Chula Vista CA
$107 nightly
The price is $124 total per night from Mar 1 to Mar 2
$124 total
Mar 1 - Mar 2
Total with taxes and fees
9/10 Wonderful! (2,047 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent South San Diego hotel reviews by fellow wanderers

The Dana on Mission Bay

The Dana on Mission Bay

5 out of 5
Posted 17 hours ago
Travelocity Verified Review
"Clean rooms, but small. Good pools and amenities. Had to pay additional parking and resort fee. "
A verified traveler stayed at The Dana on Mission Bay
The Dana on Mission Bay

Explore More Ways to Travel with Travelocity