Book Hotels in South San Diego, CA

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Top South San Diego hotels

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
$266 nightly
The price is $308 total per night from Oct 4 to Oct 5
$308 total
Oct 4 - Oct 5
Total with taxes and fees
This eco-certified hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi ...
"Love the location, loved the hotel and the layout of the hotel. We had a great room that overlooked the water. Having all the little markets on the water was fun to explore. We got an updated room for an additional $25. I’m glad we did. It was a great room."

Reviewed on Sep 29, 2025

Opens in a new windowManchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $175 total per night from Nov 2 to Nov 3
$175 total
Nov 2 - Nov 3
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
"The hotel was clean, the room was nice. The only issue was with the location of the AC, but it was not that big of an issue for us, besides when getting ready in the bathroom and getting blasted with cold air."

Reviewed on Oct 1, 2025

Opens in a new windowThe Dana on Mission Bay
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $277 total per night from Oct 23 to Oct 24
$277 total
Oct 23 - Oct 24
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Clean room"

Reviewed on Oct 1, 2025

Opens in a new windowHard Rock Hotel San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $138 total per night from Oct 13 to Oct 14
$138 total
Oct 13 - Oct 14
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Clean room"

Reviewed on Sep 27, 2025

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4 out of 5
830 Sixth Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $145 total per night from Oct 12 to Oct 13
$145 total
Oct 12 - Oct 13
Total with taxes and fees
This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and dry cleaning are also offered.
"Nice room!"

Reviewed on Sep 26, 2025

Opens in a new windowPalihotel San Diego Gaslamp Quarter
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$177 nightly
The price is $205 total per night from Oct 5 to Oct 6
$205 total
Oct 5 - Oct 6
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, express check-out, and ...
"Awesome hotel, great room, beautiful bayside view."

Reviewed on Sep 30, 2025

Opens in a new windowWyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $126 total per night from Oct 5 to Oct 6
$126 total
Oct 5 - Oct 6
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"Location"

Reviewed on Oct 1, 2025

Opens in a new windowHandlery Hotel
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S, San Diego, CA
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $113 total per night from Oct 5 to Oct 6
$113 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"Fast check in"

Reviewed on Sep 30, 2025

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Oct 9 to Oct 10
$108 total
Oct 9 - Oct 10
Total with taxes and fees
An outdoor pool, self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Traveling on business? Take advantage of the ...
"the hotel was very clean and the front desk was very friendly"

Reviewed on Sep 30, 2025

Opens in a new windowWyndham Garden San Diego Near SeaWorld
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap South San Diego hotels

The Rambler

The Rambler

225 Bay Blvd, Chula Vista, CA
$99 nightly
The price is $115 total per night from Oct 6 to Oct 7
$115 total
Oct 6 - Oct 7
Total with taxes and fees
9/10 Wonderful! (1,958 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent South San Diego hotel reviews by fellow wanderers

Handlery Hotel

Handlery Hotel

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Location"
A verified traveler stayed at Handlery Hotel
Handlery Hotel

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