Book Hotels in South San Diego, CA

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Oct 19 - Oct 20
Tomorrow
Oct 20 - Oct 21
Next weekend
Oct 24 - Oct 26
In two weeks
Oct 31 - Nov 2

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top South San Diego hotels

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $150 total per night from Oct 26 to Oct 27
$150 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features an outdoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the hot tub and free buffet breakfast ...
"The staff was amazing, even helped me get a list item from my Uber driver. An unexpected homeless camp showed up outside of the entry and the staff took care of the situation with speed, safety for guests as well as respect for the campers. I'm looking forward to stay again."

Reviewed on Oct 13, 2025

Opens in a new windowHampton Inn & Suites by Hilton San Diego SeaWorld
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
$235 nightly
The price is $272 total per night from Nov 19 to Nov 20
$272 total
Nov 19 - Nov 20
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Clean rooms, great staf, convenient to restaurant's, ferry to coronado island and train system"

Reviewed on Oct 18, 2025

Opens in a new windowHard Rock Hotel San Diego
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4 out of 5
4000 Coronado Bay Rd, Coronado, CA
Fully refundableReserve now, pay when you stay
$240 nightly
The price is $266 total per night from Oct 26 to Oct 27
$266 total
Oct 26 - Oct 27
Total with taxes and fees
A full-service spa, a marina, and 3 outdoor pools are all featured at this hotel. Take the free beach shuttle and relax with sun loungers and beach umbrellas. ...
"Jade at the front desk was super friendly and by far the best interaction. She was great! We’ve stayed here several times in the past and were all great stays. This time I must say our room was not great. The bed and the bathroom was clean but other areas within the room were not. The floor definitely ..."

Reviewed on Oct 17, 2025

Opens in a new windowLoews Coronado Bay Resort
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $175 total per night from Oct 20 to Oct 21
$175 total
Oct 20 - Oct 21
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
"Pool area was great"

Reviewed on Oct 18, 2025

Opens in a new windowThe Dana on Mission Bay
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $126 total per night from Nov 2 to Nov 3
$126 total
Nov 2 - Nov 3
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"Clean"

Reviewed on Oct 18, 2025

Opens in a new windowHandlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $186 total per night from Oct 26 to Oct 27
$186 total
Oct 26 - Oct 27
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Nice location and close to water front and cruise port."

Reviewed on Oct 18, 2025

Opens in a new windowWyndham San Diego Bayside
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Oct 26 to Oct 27
$131 total
Oct 26 - Oct 27
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Staff at time of check in were great, clean room."

Reviewed on Oct 17, 2025

Opens in a new windowHilton San Diego Mission Valley
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St, San Diego, CA
Fully refundable
$148 nightly
The price is $172 total per night from Oct 28 to Oct 29
$172 total
Oct 28 - Oct 29
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and free internet ...
"Me encantó la vista .!!"

Reviewed on Oct 19, 2025

Opens in a new windowCourtyard by Marriott San Diego Downtown Little Italy
Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor

3.5 out of 5
San Diego
$78 nightly
The price is $88 total per night from Nov 11 to Nov 12
$88 total
Nov 11 - Nov 12
Total with taxes and fees
This hotel features an outdoor pool and a rooftop terrace. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free full breakfast ...
"I’ve not had breakfast yet,, checked in at 2, it’s now 8:55 pm"

Reviewed on Oct 18, 2025

Opens in a new windowComfort Inn San Diego Airport At The Harbor
Don't see what you're looking for?
See all available properties in South San Diego
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap South San Diego hotels

The Rambler

The Rambler

225 Bay Blvd, Chula Vista, CA
$99 nightly
The price is $115 total per night from Oct 26 to Oct 27
$115 total
Oct 26 - Oct 27
Total with taxes and fees
9/10 Wonderful! (1,981 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent South San Diego hotel reviews by fellow wanderers

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

5 out of 5
Posted 12 hours ago
Travelocity Verified Review
"Me encantó la vista .!! "
A verified traveler stayed at Courtyard by Marriott San Diego Downtown Little Italy
Courtyard by Marriott San Diego Downtown Little Italy

Explore More Ways to Travel with Travelocity