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Top hotels in Otay Mesa

Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$197 nightly
The price is $227 total per night from Jul 7 to Jul 8
$227 total
Jul 7 - Jul 8
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"Loved our lower level Marina view room. BUT that outpost area should have comfy lounge chairs. That is THE spot you’d want to hang out at and those hard cheap plastic chairs just don’t cut it. Also, don’t want your money on the side of hash browns. At the restaurant. $6 for the tiniest portion. Almost ..."

Reviewed on Jul 3, 2026

Opens in a new windowBay Club Hotel & Marina
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$225 nightly
The price is $261 total per night from Jul 5 to Jul 6
$261 total
Jul 5 - Jul 6
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Room was dusty and tv didn't work. We were moved to another room but was not convenient. That room was also dusty."

Reviewed on Jul 3, 2026

Opens in a new windowHard Rock Hotel San Diego
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$346 nightly
The price is $401 total per night from Jul 8 to Jul 9
$401 total
Jul 8 - Jul 9
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"everything I could ask for in a hotel"

Reviewed on Jul 1, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$341 nightly
The price is $392 total per night from Jul 6 to Jul 7
$392 total
Jul 6 - Jul 7
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"It was a great experience highly recommend for families looking for fun activities for the kids!"

Reviewed on Jul 3, 2026

Opens in a new windowParadise Point Resort & Spa
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
$134 nightly
The price is $156 total per night from Aug 2 to Aug 3
$156 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"the breakfast was really good &’ loved that the bar stayed open late"

Reviewed on Jul 2, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Jul 6 to Jul 7
$211 total
Jul 6 - Jul 7
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Great location"

Reviewed on Jul 3, 2026

Opens in a new windowWyndham San Diego Bayside
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
$144 nightly
The price is $164 total per night from Aug 2 to Aug 3
$164 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"We stayed here for two nights (Friday and Saturday) with our kids. We arrived in San Diego around 11:00 p.m. and asked for extra pillows, but were told none were available. It wasn’t a huge issue since my kids were able to share. The next day, I requested that our room be cleaned, but the front desk ..."

Reviewed on Jul 2, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place San Diego CA
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Aug 2 to Aug 3
$146 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features an outdoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the hot tub and free full breakfast ...
"Room"

Reviewed on Jul 2, 2026

Opens in a new windowBest Western Inn & Suites San Diego – Zoo/SeaWorld Area
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$340 nightly
The price is $391 total per night from Jul 26 to Jul 27
$391 total
Jul 26 - Jul 27
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a hot tub are all featured at this smoke-free resort. Spend a day at the beach surfing, or relax with free beach ...
Opens in a new windowBahia Resort Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

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