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Top hotels in Otay Mesa
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$220 nightly
The price is $252 total per night from Jul 1 to Jul 2
$252 total
Jul 1 - Jul 2
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"The hotel itself was nice but when we got into our room it was not cleaned well at all. We then got switched to another room but it did not include what I paid for and that room was also not properly cleaned so we then had to be switched again for the third time to another room that they intentionally ..."
Reviewed on Jun 21, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$316 nightly
The price is $366 total per night from Jun 25 to Jun 26
$366 total
Jun 25 - Jun 26
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Good location"
Reviewed on Jun 21, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$225 nightly
The price is $261 total per night from Jun 25 to Jun 26
$261 total
Jun 25 - Jun 26
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"This place was really nice. The only bad thing I can say is that, I was disappointed that out tv wasn’t working. We were looking forward to watch the soccer game in the room but couldn’t. Other than that, everything was perfect."
Reviewed on Jun 21, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$325 nightly
The price is $374 total per night from Jun 28 to Jun 29
$374 total
Jun 28 - Jun 29
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"We’ve stayed here for over 10+ years. Still an amazing choice for us. Please work on the landscaping. It used to look more lush."
Reviewed on Jun 21, 2026
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
$345 nightly
The price is $396 total per night from Jul 6 to Jul 7
$396 total
Jul 6 - Jul 7
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a hot tub are all featured at this smoke-free resort. Spend a day at the beach surfing, or relax with free beach ...
"The property grounds were OK, the room was disgusting. Carpet was dirty and stained, small room, old dingy wallpaper, leaky tub with mold on ceiling and not enough outlets. We also encountered a cockroach in the room in the middle of the night. Overall the room was gross, I advised staff the next ..."
Reviewed on Jun 21, 2026
The Sofia Hotel
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $149 total per night from Jun 29 to Jun 30
$149 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"The ac could be better I had it set in 69 and the room didn’t feel like it"
Reviewed on Jun 21, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Jun 29 to Jun 30
$211 total
Jun 29 - Jun 30
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"The room itself was a little worn with wear and tear, it could use a refresh. That aside the room was very comfortable and clean. The location to everything was excellent, and with the bay view rooms you couldnt beat the view. I did not interact with anyone except at check in, and I wish I remembered ..."
Reviewed on Jun 21, 2026
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
Fully refundable
$145 nightly
The price is $165 total per night from Jul 5 to Jul 6
$165 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"Super comfortable and clean. Yummy breakfast. Eggs, two types of sausage, toast, bagels, cereal, oatmeal, pancakes, yogurt, fruit, crab and orange juice, coffee, milk, potatoes"
Reviewed on Jun 21, 2026
Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $139 total per night from Jul 19 to Jul 20
$139 total
Jul 19 - Jul 20
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
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Reviewed on Jun 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Otay Mesa hotel reviews by fellow wanderers
Manchester Grand Hyatt San Diego
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Good location"
A verified traveler stayed at Manchester Grand Hyatt San Diego
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