Find a Hotel in Otay Mesa
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Top hotels in Otay Mesa
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $194 total per night from Oct 26 to Oct 27
$194 total
Oct 26 - Oct 27
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"Beautiful spot"
Reviewed on Oct 21, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$195 nightly
The price is $226 total per night from Nov 22 to Nov 23
$226 total
Nov 22 - Nov 23
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...
"Very smooth check in from valet to the front desk. The bar was convenient and walking distance to restaurants and Petco Park"
Reviewed on Oct 22, 2026
Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $102 total per night from Nov 4 to Nov 5
$102 total
Nov 4 - Nov 5
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"A sour urine smell permeated the room and the friendly staff (the only upside of my stay) let me know it was the only room available. Turns out the smell came from someone urinating in the A/C unit. The only way to stop the smell was to turn it off. So I stayed in a hot muggy urine smelling room ..."
Reviewed on Oct 22, 2026
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
Fully refundable
$130 nightly
The price is $148 total per night from Nov 22 to Nov 23
$148 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Oct 25 to Oct 26
$211 total
Oct 25 - Oct 26
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $303 total per night from Oct 23 to Oct 24
$303 total
Oct 23 - Oct 24
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Handlery Hotel
950 Hotel Cir N San Diego CA
$111 nightly
The price is $128 total per night from Nov 16 to Nov 17
$128 total
Nov 16 - Nov 17
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Hotel del Coronado, Curio Collection by Hilton
1500 Orange Ave Coronado CA
Fully refundableReserve now, pay when you stay
$558 nightly
The price is $619 total per night from Oct 28 to Oct 29
$619 total
Oct 28 - Oct 29
Total with taxes and fees
A private beach, 6 restaurants, and an outdoor pool are all featured at this Victorian resort. Relax with sun loungers and beach umbrellas, and cool off with ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Otay Mesa hotel reviews by fellow wanderers
The Alcala Hotel Mission Valley/Seaworld
5 out of 5
Posted 7 hours ago
Travelocity Verified Review
"Good"
A verified traveler stayed at The Alcala Hotel Mission Valley/Seaworld
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