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Top hotels in Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$248 nightly
The price is $287 total per night from Apr 2 to Apr 3
$287 total
Apr 2 - Apr 3
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
I arrived on a Friday at 5 PM, but my room wasn’t ready until 6:30 PM. After a long drive, I was already quite tired, so the delay was disappointing. That said, the staff handled the situation exceptionally well, they offered a complimentary drink and upgraded my room, which I really appreciated. ...

Reviewed on Mar 29, 2026

Opens in a new windowHard Rock Hotel San Diego
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$346 nightly
The price is $401 total per night from Apr 22 to Apr 23
$401 total
Apr 22 - Apr 23
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
N/A Self-parking is expensive.

Reviewed on Mar 28, 2026

Opens in a new windowManchester Grand Hyatt San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundable
$135 nightly
The price is $157 total per night from Apr 23 to Apr 24
$157 total
Apr 23 - Apr 24
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
I do not recommend.

Reviewed on Mar 28, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$288 nightly
The price is $331 total per night from Apr 26 to Apr 27
$331 total
Apr 26 - Apr 27
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
The location and the island is perfect

Reviewed on Mar 29, 2026

Opens in a new windowParadise Point Resort & Spa
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $148 total per night from Apr 1 to Apr 2
$148 total
Apr 1 - Apr 2
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Excellent Hotel.

Reviewed on Mar 29, 2026

Opens in a new windowHandlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Apr 2 to Apr 3
$211 total
Apr 2 - Apr 3
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
You were severely understaffed at Claim Jumpers at breakfast. We gave up and bought extortionately priced muffins instead. Airline staff plugged up the first shuttle we might have caught from the airport so we stood around for an empty half hour waiting for the next one.

Reviewed on Mar 29, 2026

Opens in a new windowWyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$163 nightly
The price is $188 total per night from Apr 4 to Apr 5
$188 total
Apr 4 - Apr 5
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
The hotel was great unfortunately the pool cabana was closed the entire time every time I ask the staff when it will be opened I got truck shoulders and no real response. It didn’t seem like anybody knew what was going on. Also, upon the arrival to the hotel, I wasn’t even welcomed when I said hi ...

Reviewed on Mar 29, 2026

Opens in a new windowSheraton San Diego Resort
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $123 total per night from Apr 26 to Apr 27
$123 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
4/5 Comfortable beds, nice heated pool and hot tub, workout room was very tiny and crappy worn out equipment. The pictures online showed a different picture of workout room. Was very disappointed it was like a small closet not enough room to workout in at all.

Reviewed on Mar 27, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $94 total per night from Apr 2 to Apr 3
$94 total
Apr 2 - Apr 3
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
Room smelled musty upon arrival. Condition of carpet is fair with many old stains. Staff did a great job and all were friendly and efficient. The property has definitely seen better days

Reviewed on Mar 29, 2026

Opens in a new windowBest Western Seven Seas
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

Sheraton San Diego Resort

Sheraton San Diego Resort

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"The hotel was great unfortunately the pool cabana was closed the entire time every time I ask the staff when it will be opened I got truck shoulders and no real response. It didn’t seem like anybody knew what was going on. Also, upon the arrival to the hotel, I wasn’t even welcomed when I said hi I’m checking in. It was responded by ID."
A verified traveler stayed at Sheraton San Diego Resort
Sheraton San Diego Resort

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