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Top hotels in Otay Mesa

Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$198 nightly
The price is $228 total per night from Sep 1 to Sep 2
$228 total
Sep 1 - Sep 2
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"Everything was great. We were in two different rooms and they were both very nice, especially the second one which was a King suite with a sofa bed. Great location with two balconies and a great view to the outside concert venue next door (free concert!). If I had to complain about anything, it would ..."

Reviewed on Aug 3, 2026

Opens in a new windowBay Club Hotel & Marina
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$250 nightly
The price is $290 total per night from Aug 26 to Aug 27
$290 total
Aug 26 - Aug 27
Total with taxes and fees
This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
"This place was amazing great location! Only downside was the parking garage, already narrow parking garage, coupled with big cars parking in the compact spots and on level three they are using part of the row for storage so you have to squeeze in. Other than that great stay but be mindful if you ..."

Reviewed on Aug 3, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $265 total per night from Aug 12 to Aug 13
$265 total
Aug 12 - Aug 13
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Overall the location is fantastic. You are right in the heart of everything with access to the trolley right across the street or a quick walk up the block. Everything is right there. The hotel itself is starting to show its age. The room was ok, bed the comfortable but everything else was ok."

Reviewed on Aug 4, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$301 nightly
The price is $346 total per night from Aug 23 to Aug 24
$346 total
Aug 23 - Aug 24
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"Room was ok, but could use some maintenance. Toilet didn’t flush properly. Had to hold down flush button, to get a proper flush, toilet needs to be secured, rocks back and forth. Caulking of toilet is sloppy, walls needed patching and painting in some areas. Bath exhaust fan didn’t work. Drapes had ..."

Reviewed on Aug 4, 2026

Opens in a new windowParadise Point Resort & Spa
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $303 total per night from Sep 2 to Sep 3
$303 total
Sep 2 - Sep 3
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a hot tub are all featured at this smoke-free resort. Traveling for business? Take advantage of the business center, ...
"The location, staff and restaurants were excellent. Room was very dated. Bed too high for handicapped person."

Reviewed on Aug 4, 2026

Opens in a new windowBahia Resort Hotel
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$177 nightly
The price is $205 total per night from Aug 31 to Sep 1
$205 total
Aug 31 - Sep 1
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"One of the elevators was broken for the whole stay (5 days), and we needed to wait so long to get a key for the car in the parking lot."

Reviewed on Aug 3, 2026

Opens in a new windowThe Sofia Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Aug 6 to Aug 7
$211 total
Aug 6 - Aug 7
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"I’d say book this stay for a budget friendly but rugged stay. Shower bottles were not well maintained, run down furniture, and tissue stuck in a hole in the ceiling rather than a lightbulb installed. Poor bathroom lighting."

Reviewed on Aug 4, 2026

Opens in a new windowWyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $194 total per night from Aug 23 to Aug 24
$194 total
Aug 23 - Aug 24
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
"The property was not worth the amount that we were charged based on how clean and undated other properties. I will not be starting there again"

Reviewed on Aug 3, 2026

Opens in a new windowSheraton San Diego Resort
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $269 total per night from Sep 1 to Sep 2
$269 total
Sep 1 - Sep 2
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
Opens in a new windowThe Dana on Mission Bay
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

4 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Clean room , clean hotel. Front desk staff can improve a bit more on their customer service."
A verified traveler stayed at Omni San Diego Hotel at the Ballpark
Omni San Diego Hotel at the Ballpark

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