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Top hotels in Otay Mesa

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$276 nightly
The price is $320 total per night from Jun 5 to Jun 6
$320 total
Jun 5 - Jun 6
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Wonderful hotel has all the best!"

Reviewed on Jun 1, 2026

Opens in a new windowManchester Grand Hyatt San Diego
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$192 nightly
The price is $223 total per night from Jun 29 to Jun 30
$223 total
Jun 29 - Jun 30
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
"The hotel had peeling paint, tiny elevators that creaked and reeked of smoke, and a sink not attached to the bathroom, and there was no light actually in the bathroom - which we just felt was strange. All 3 times we went to the valet stand, no one was there, despite a call down beforehand. The room ..."

Reviewed on Jun 1, 2026

Opens in a new windowThe Sofia Hotel
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$277 nightly
The price is $319 total per night from Jun 3 to Jun 4
$319 total
Jun 3 - Jun 4
Total with taxes and fees
A full-service spa, 2 restaurants, and 5 outdoor tennis courts are all featured at this Mediterranean resort. There's fun for all ages with a children's pool ...
"We fell in love with this resort and will be recommending it to everyone we know! It was our kids’ birthdays and the staff went above and beyond, they decorated the room for us so when our little ones arrived they were so surprised. The room was spacious and clean; we enjoyed having a patio that ..."

Reviewed on Jun 1, 2026

Opens in a new windowSan Diego Mission Bay Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Jun 3 to Jun 4
$211 total
Jun 3 - Jun 4
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Location"

Reviewed on Jun 1, 2026

Opens in a new windowWyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$213 nightly
The price is $245 total per night from Jun 28 to Jun 29
$245 total
Jun 28 - Jun 29
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
"Overall excellent experience; parking is up there in price but the location and views are amazing!"

Reviewed on May 31, 2026

Opens in a new windowSheraton San Diego Resort
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
$140 nightly
The price is $159 total per night from Jun 14 to Jun 15
$159 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"The room was not nice like the pictures on the website The room was old and not nice"

Reviewed on Jun 1, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Jun 2 to Jun 3
$97 total
Jun 2 - Jun 3
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
"It was overall a good stay. Pillows sucked but overall not bad."

Reviewed on May 31, 2026

Opens in a new windowBest Western Seven Seas
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $102 total per night from Jun 3 to Jun 4
$102 total
Jun 3 - Jun 4
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"Not bad"

Reviewed on Jun 1, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $246 total per night from Jun 7 to Jun 8
$246 total
Jun 7 - Jun 8
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
Opens in a new windowHard Rock Hotel San Diego
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

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