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Top hotels in Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$262 nightly
The price is $303 total per night from Apr 29 to Apr 30
$303 total
Apr 29 - Apr 30
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
Staff was very helpful and attentive.

Reviewed on Apr 26, 2026

Opens in a new windowHard Rock Hotel San Diego
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $274 total per night from May 25 to May 26
$274 total
May 25 - May 26
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
The Manchester Hyatt always delivers as expected. They have valet and bellhop which is important to me traveling with a special needs child and I need the convenience of having some help moving all of the luggage up to the room and parking the car for us. The room was well appointed and clean. They ...

Reviewed on Apr 25, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$264 nightly
The price is $303 total per night from May 10 to May 11
$303 total
May 10 - May 11
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
The resort is lovely and has a very tropical lush feel we were stay vacationing 30 minutes from home and it really felt like we’d flown to Hawaii or somewhere in the South Pacific. The accommodation was great for a family of four, with a nice bungalow, large bedroom space and cute bathroom and we ...

Reviewed on Apr 25, 2026

Opens in a new windowParadise Point Resort & Spa
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundable
$127 nightly
The price is $147 total per night from May 25 to May 26
$147 total
May 25 - May 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
The beds were really comfortable And the guy at the front dest was really professional and helpful

Reviewed on Apr 26, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$150 nightly
The price is $174 total per night from Apr 30 to May 1
$174 total
Apr 30 - May 1
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Awesome staff!!!

Reviewed on Apr 26, 2026

Opens in a new windowThe Sofia Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Apr 28 to Apr 29
$211 total
Apr 28 - Apr 29
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
Breakfast was very good!

Reviewed on Apr 25, 2026

Opens in a new windowWyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $144 total per night from Apr 27 to Apr 28
$144 total
Apr 27 - Apr 28
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Rooms felt old and dingy. The photos tricked us. We paid extra for a room surrounding the pool like they have in the photos but got placed in some other room in a building down from the main office. Floor felt and looked perma dirty. Place could use a good update to match the advertising photos.

Reviewed on Apr 25, 2026

Opens in a new windowHandlery Hotel
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $194 total per night from May 25 to May 26
$194 total
May 25 - May 26
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Overall amazing

Reviewed on Apr 22, 2026

Opens in a new windowSheraton San Diego Resort
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $94 total per night from Apr 27 to Apr 28
$94 total
Apr 27 - Apr 28
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
M

Reviewed on Apr 25, 2026

Opens in a new windowBest Western Seven Seas
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

The Dana on Mission Bay

The Dana on Mission Bay

3 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Everything was very nice. Water pressure was severely lacking. Made taking a shower feel like a poor experience. Could use an update."
A verified traveler stayed at The Dana on Mission Bay
The Dana on Mission Bay

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