Find a Hotel in Otay Mesa

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top hotels in Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...
"The layout of the tppm was awkward with a sink in the middle. Carpet was rippled and was a trip hazard. One television did not work. There were bottle caps on the floor that were not ours, so the room had not been thoroughly cleaned prior. Don't think I would return."

Reviewed on Nov 12, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$245 nightly
The price is $282 total per night from Dec 13 to Dec 14
$282 total
Dec 13 - Dec 14
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"Had a great time"

Reviewed on Nov 12, 2026

Opens in a new windowParadise Point Resort & Spa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Near everything"

Reviewed on Nov 12, 2026

Opens in a new windowWyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $94 total per night from Dec 13 to Dec 14
$94 total
Dec 13 - Dec 14
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"Great place. Clean and friendly staff"

Reviewed on Nov 11, 2026

Opens in a new windowHandlery Hotel
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $97 total per night from Nov 30 to Dec 1
$97 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"Las camas y almohadas muy confortables y sábanas blancas limpias gracias buen café"

Reviewed on Nov 12, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

2.5 out of 5
San Diego CA
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $92 total per night from Dec 13 to Dec 14
$92 total
Dec 13 - Dec 14
Total with taxes and fees
This hotel features an outdoor pool and a gym. Enjoy the hot tub and free perks like continental breakfast and WiFi in public areas. Self parking, a garden, ...
"Staff were very friendly and helpful. Beds were comfortable. A bit noisy from freeway traffic, but that was to be expected due to location."

Reviewed on Nov 12, 2026

Opens in a new windowThe Alcala Hotel Mission Valley/Seaworld
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
$130 nightly
The price is $148 total per night from Dec 13 to Dec 14
$148 total
Dec 13 - Dec 14
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Opens in a new windowHoliday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Nov 15 to Nov 16
$97 total
Nov 15 - Nov 16
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
Opens in a new windowBest Western Seven Seas
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Opens in a new windowSheraton San Diego Resort
Don't see what you're looking for?
See all available properties in Otay Mesa
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity