Find a Hotel in Otay Mesa
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Top hotels in Otay Mesa
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is $207 total per night from Sep 14 to Sep 15
$207 total
per night
Sep 14 - Sep 15
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"Great place to stay for the night!"
Reviewed on Sep 13, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is $274 total per night from Sep 27 to Sep 28
$274 total
per night
Sep 27 - Sep 28
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...
"Great location, nice staff, clean rooms, fun pool!"
Reviewed on Sep 13, 2026
Handlery Hotel
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
The price is $136 total per night from Oct 7 to Oct 8
$136 total
per night
Oct 7 - Oct 8
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"Poor area clean, nice little bar in the pool premises perfect for a swim and a drink enjoying sunny Sand Diego Weather! Highly recommend place to stay! Close to everything"
Reviewed on Sep 12, 2026
Best Western Seven Seas
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
The price is $97 total per night from Sep 20 to Sep 21
$97 total
per night
Sep 20 - Sep 21
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is $292 total per night from Oct 4 to Oct 5
$292 total
per night
Oct 4 - Oct 5
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
The price is $211 total per night from Sep 20 to Sep 21
$211 total
per night
Sep 20 - Sep 21
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
The price is $310 total per night from Sep 27 to Sep 28
$310 total
per night
Sep 27 - Sep 28
This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is $245 total per night from Sep 27 to Sep 28
$245 total
per night
Sep 27 - Sep 28
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Omni San Diego Hotel at the Ballpark
675 L St San Diego CA
The price is $258 total per night from Sep 27 to Sep 28
$258 total
per night
Sep 27 - Sep 28
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Otay Mesa hotel reviews by fellow wanderers
Bay Club Hotel & Marina
5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Great place to stay for the night!"
A verified traveler stayed at Bay Club Hotel & Marina
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