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Top hotels in Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...
"Amazing stay! Loved this hotel. It was so close to our event, walking distance. Staff was super friendly! Also recommend MaryJanes for breakfast so yummy! Thank you!"

Reviewed on Nov 10, 2026

Opens in a new windowHard Rock Hotel San Diego
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
$144 nightly
The price is $164 total per night from Nov 15 to Nov 16
$164 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"Will stay again, I loved it"

Reviewed on Nov 10, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Checking in was an absolute nightmare. Staff directed us to the parking structure without letting us unload our luggage. We proceeded to the parking structure only to realize that there was no elevator. Staff that directed us did not tell us that there was no elevator. Once we made it to the lobby ..."

Reviewed on Nov 10, 2026

Opens in a new windowWyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$90 nightly
The price is $104 total per night from Dec 1 to Dec 2
$104 total
Dec 1 - Dec 2
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"This property had such a cool, vintage California feel. Even though it is an old building, things were well kept up and clean. The beds were comfortable and I was glad the room had a coffee maker and a safe. The restaurant on site was good and all employees I interacted with were friendly. Parking ..."

Reviewed on Nov 10, 2026

Opens in a new windowHandlery Hotel
The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

2.5 out of 5
San Diego CA
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $92 total per night from Dec 9 to Dec 10
$92 total
Dec 9 - Dec 10
Total with taxes and fees
This hotel features an outdoor pool and a gym. Enjoy the hot tub and free perks like continental breakfast and WiFi in public areas. Self parking, a garden, ...
"First when I checked in they changed my room from a king size bed to two double beds. She said it was an upgrade I would prefer the bigger bed then two beds. Then the shower was leaking all over so we couldn’t shower so we asked if they can fix it but they didn’t have maintenance at the moment. They ..."

Reviewed on Nov 10, 2026

Opens in a new windowThe Alcala Hotel Mission Valley/Seaworld
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Nov 12 to Nov 13
$97 total
Nov 12 - Nov 13
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
"Everything was good till"

Reviewed on Nov 10, 2026

Opens in a new windowBest Western Seven Seas
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$231 nightly
The price is $266 total per night from Dec 5 to Dec 6
$266 total
Dec 5 - Dec 6
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
Opens in a new windowParadise Point Resort & Spa
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Opens in a new windowSheraton San Diego Resort
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Nov 15 to Nov 16
$97 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

Handlery Hotel

Handlery Hotel

5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"This property had such a cool, vintage California feel. Even though it is an old building, things were well kept up and clean. The beds were comfortable and I was glad the room had a coffee maker and a safe. The restaurant on site was good and all employees I interacted with were friendly. Parking was a bit pricey at $24 a day, but that’s really my only complaint. I would stay here again."
A verified traveler stayed at Handlery Hotel
Handlery Hotel

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