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Top hotels in Otay Mesa

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $305 total per night from May 25 to May 26
$305 total
May 25 - May 26
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Great location and clean hotel.

Reviewed on May 9, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $235 total per night from May 12 to May 13
$235 total
May 12 - May 13
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
It was awesome

Reviewed on May 11, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$264 nightly
The price is $303 total per night from May 25 to May 26
$303 total
May 25 - May 26
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
We used to come here for many years with our kids in the early 2000's. Back then the resort was in great condition. The street pavement was smooth, for kids to ride scooters and skateboards. All the landscape lighting worked. All the paint was good, etc. They also had a guard gate which limited access ...

Reviewed on May 11, 2026

Opens in a new windowParadise Point Resort & Spa
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundable
$118 nightly
The price is $137 total per night from May 12 to May 13
$137 total
May 12 - May 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Had to pay for parking was what I didn’t like.

Reviewed on May 11, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $186 total per night from May 12 to May 13
$186 total
May 12 - May 13
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Pros: The staff was great, rooms were clean, decor was nice, a/c worked. Cons: the elevator and room was super small. Like abnormally small. Made me a little claustrophobic when I was in the elevator. The valet parking was expensive (50 dollars) especially when you are expected to tip- and you should). ...

Reviewed on May 11, 2026

Opens in a new windowThe Sofia Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $201 total per night from May 25 to May 26
$201 total
May 25 - May 26
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
We loved our room and the view. An excellent breakfast place with great coffee and food was steps away. Really good restaurants steps away too. We will absolutely stay here again.

Reviewed on May 11, 2026

Opens in a new windowWyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $176 total per night from May 24 to May 25
$176 total
May 24 - May 25
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Very clean room. Lots of friendly helpful staff. The cool air wasn’t working and they had maintenance come right away and fix it. The pool was very large and a great temperature for swimming in early May.

Reviewed on May 10, 2026

Opens in a new windowHandlery Hotel
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from May 27 to May 28
$97 total
May 27 - May 28
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
Stayed for a week and it was a beautiful property with a great pool. Well worth the price!

Reviewed on May 11, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $87 total per night from May 12 to May 13
$87 total
May 12 - May 13
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
Nice and clean place

Reviewed on May 10, 2026

Opens in a new windowBest Western Seven Seas
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Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

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