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Top hotels in Otay Mesa

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$259 nightly
The price is $300 total per night from Aug 25 to Aug 26
$300 total
Aug 25 - Aug 26
Total with taxes and fees
This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
"Clean room and remodeled. Kids had fun at the coastal pool"

Reviewed on Aug 3, 2026

Opens in a new windowManchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $269 total per night from Sep 1 to Sep 2
$269 total
Sep 1 - Sep 2
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
"clean room"

Reviewed on Aug 3, 2026

Opens in a new windowThe Dana on Mission Bay
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $265 total per night from Aug 12 to Aug 13
$265 total
Aug 12 - Aug 13
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Super clean and near everything."

Reviewed on Aug 3, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$269 nightly
The price is $309 total per night from Sep 1 to Sep 2
$309 total
Sep 1 - Sep 2
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"The resort has a lot of amenities. The pool is nice and has shallow areas for kids and babies. However, peoples dogs were also in the pool. The access to the beaches was close and not overcrowded. There were small crustaceans that did bite in shallow water, not ideal for babies as it leaves welts ..."

Reviewed on Aug 3, 2026

Opens in a new windowParadise Point Resort & Spa
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $303 total per night from Sep 1 to Sep 2
$303 total
Sep 1 - Sep 2
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a hot tub are all featured at this smoke-free resort. Traveling for business? Take advantage of the business center, ...
"Wonderful staff and always clean, property is beautiful on the bay!"

Reviewed on Aug 3, 2026

Opens in a new windowBahia Resort Hotel
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $200 total per night from Aug 4 to Aug 5
$200 total
Aug 4 - Aug 5
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"Staff was great, room was a bit smaller than expected but worked well for my family of 3. There was a hot water issue but fixed right away and one day we were left with no towels but again immediately corrected when we asked, brought up within 5 mins. I could see dust around the closet edges but ..."

Reviewed on Aug 3, 2026

Opens in a new windowThe Sofia Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Aug 5 to Aug 6
$211 total
Aug 5 - Aug 6
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"The location was perfect for walking around. The room was adequate; however, the bathroom sink and shower had draining issues which was a nuisance given the fact we were staying one night. The room smelled musty as well. The ice machine outside the room was inoperable, however a staff member happened ..."

Reviewed on Aug 2, 2026

Opens in a new windowWyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $194 total per night from Aug 23 to Aug 24
$194 total
Aug 23 - Aug 24
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
"After paying for parking at the property, the cost for one night in this hotel was $460, so I had high expectations. The hotel mixed up which tower we were in, so we had to walk seven minutes to the other tower with all of our luggage for check-in - not the end of the world. It’s a beautiful walk ..."

Reviewed on Aug 3, 2026

Opens in a new windowSheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$194 nightly
The price is $223 total per night from Sep 3 to Sep 4
$223 total
Sep 3 - Sep 4
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Opens in a new windowBay Club Hotel & Marina
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

Handlery Hotel

Handlery Hotel

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Super amazing staff, very friendly and attentive. Definitely cannot wait to stay again"
A verified traveler stayed at Handlery Hotel
Handlery Hotel

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