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Top hotels in Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$266 nightly
The price is $308 total per night from Apr 15 to Apr 16
$308 total
Apr 15 - Apr 16
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
Was all good other than being disappointed for not really feeling welcomed or get the perks as a VIP member of Orbitz. I showed them my VIP membership and asked for a complementary late checkout and got an extra hour. No mention of other complementary service or drinks, nothing. I had to comeback ...

Reviewed on Apr 11, 2026

Opens in a new windowHard Rock Hotel San Diego
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$276 nightly
The price is $320 total per night from May 7 to May 8
$320 total
May 7 - May 8
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Great location

Reviewed on Apr 11, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$235 nightly
The price is $270 total per night from May 10 to May 11
$270 total
May 10 - May 11
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
Fun location. Lots of amenities. Great pools. Food options on sight. Great s

Reviewed on Apr 12, 2026

Opens in a new windowParadise Point Resort & Spa
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundable
$127 nightly
The price is $147 total per night from May 11 to May 12
$147 total
May 11 - May 12
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Nice hotel. Convenient to the cruise port. Restaurant had a limited menu.

Reviewed on Apr 11, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$145 nightly
The price is $169 total per night from May 10 to May 11
$169 total
May 10 - May 11
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
Expensive parking. Clean room ac worked.

Reviewed on Apr 11, 2026

Opens in a new windowThe Sofia Hotel
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $148 total per night from Apr 13 to Apr 14
$148 total
Apr 13 - Apr 14
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Front desk staff was very helpful. The pool bar staff was very friendly and made great drinks!

Reviewed on Apr 11, 2026

Opens in a new windowHandlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from May 3 to May 4
$211 total
May 3 - May 4
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
Check in is way to late. Couldn’t even use the restroom or try to shower until almost 5pm. Ended up booking a different hotel and never even checked in. Will never stay here

Reviewed on Apr 12, 2026

Opens in a new windowWyndham San Diego Bayside
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $116 total per night from Apr 14 to Apr 15
$116 total
Apr 14 - Apr 15
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
A few of the staff were very nice. The worst part of this hotel is that the air conditioning smells like mold. I had to change rooms and it still smelled bad. When you walk outside and you go around the corner and there’s an air-conditioning unit sticking out of the wall it smells horrible and it ...

Reviewed on Apr 12, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $94 total per night from Apr 21 to Apr 22
$94 total
Apr 21 - Apr 22
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
The room was musty smelling. NO Shampoo nor Conditioner in bathroom. Noise coming from parking structures.

Reviewed on Apr 12, 2026

Opens in a new windowBest Western Seven Seas
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

The Dana on Mission Bay

The Dana on Mission Bay

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"The pools were great! Kid approved. "
A verified traveler stayed at The Dana on Mission Bay
The Dana on Mission Bay

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