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Top hotels in Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $224 total per night from Jun 7 to Jun 8
$224 total
Jun 7 - Jun 8
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Lobby is very loud… yeah, it’s the Hark Rock. Like the them, but needs work. TV system was on the fritz a few times, Starbucks is outside, and it’s $70/day for valet parking! Right on Gaslamp Qtr roe though so lots of good restaurants."

Reviewed on Jun 4, 2026

Opens in a new windowHard Rock Hotel San Diego
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$306 nightly
The price is $355 total per night from Jul 1 to Jul 2
$355 total
Jul 1 - Jul 2
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Friendly courteous staff, great hotel"

Reviewed on Jun 2, 2026

Opens in a new windowManchester Grand Hyatt San Diego
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $202 total per night from Jun 29 to Jun 30
$202 total
Jun 29 - Jun 30
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
"This hotel offered an exceptional stay defined by immaculate cleanliness and modern, upscale comfort."

Reviewed on Jun 4, 2026

Opens in a new windowThe Sofia Hotel
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$365 nightly
The price is $420 total per night from Jul 5 to Jul 6
$420 total
Jul 5 - Jul 6
Total with taxes and fees
A full-service spa, 2 restaurants, and 5 outdoor tennis courts are all featured at this Mediterranean resort. There's fun for all ages with a children's pool ...
"amazing room with great views , loved the pool area and how walkable everything was."

Reviewed on Jun 4, 2026

Opens in a new windowSan Diego Mission Bay Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Jun 7 to Jun 8
$211 total
Jun 7 - Jun 8
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Wouldn’t stay again dirty and outdated"

Reviewed on Jun 4, 2026

Opens in a new windowWyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $234 total per night from Jul 5 to Jul 6
$234 total
Jul 5 - Jul 6
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
"I had an amazing trip with hotel , the view from my room was breathtaking taking every day ! Would highly recommend staying here"

Reviewed on Jun 3, 2026

Opens in a new windowSheraton San Diego Resort
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
$139 nightly
The price is $158 total per night from Jun 7 to Jun 8
$158 total
Jun 7 - Jun 8
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"We stayed May 29th for the Pitbull concert nearby. the rooms was great but the bathroom lock was missing the button, so we had to push it in with our nail. The lock worked and we were only there for night so we didn't feel like going down and complain just for a small thing. The complimentary breakfast ..."

Reviewed on Jun 4, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $113 total per night from Jun 7 to Jun 8
$113 total
Jun 7 - Jun 8
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
"Clean room"

Reviewed on Jun 4, 2026

Opens in a new windowBest Western Seven Seas
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $113 total per night from Jun 16 to Jun 17
$113 total
Jun 16 - Jun 17
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"Very old, has bad smell inside the rooms. Don’t recommend"

Reviewed on Jun 4, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

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