Find a Hotel in Otay Mesa
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Top hotels in Otay Mesa
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$198 nightly
The price is $228 total per night from Sep 1 to Sep 2
$228 total
Sep 1 - Sep 2
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"Everything is amazing!! We’ve stayed a few time and love it every time! The food is ok but service staff and property is incredible!"
Reviewed on Aug 4, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$250 nightly
The price is $290 total per night from Aug 26 to Aug 27
$290 total
Aug 26 - Aug 27
Total with taxes and fees
This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
"Everything was great, location was amazing, property is Beautiful. The only issue was we arrived at 4pm and the room was not ready."
Reviewed on Aug 4, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $265 total per night from Aug 12 to Aug 13
$265 total
Aug 12 - Aug 13
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Ok"
Reviewed on Aug 4, 2026
The Sofia Hotel
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $224 total per night from Aug 27 to Aug 28
$224 total
Aug 27 - Aug 28
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"Rude staff, they tried to charge us for the room when we pre booked, our booking came with 2 drink vouchers they made me show them proof because they wanted to argue it was only one but I had proof it is 2. The outlet didn’t work in the bathroom had to have maintenance come they were in the room ..."
Reviewed on Aug 4, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Aug 6 to Aug 7
$211 total
Aug 6 - Aug 7
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Loved it! Close to everything we needed!"
Reviewed on Aug 4, 2026
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $194 total per night from Aug 23 to Aug 24
$194 total
Aug 23 - Aug 24
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
"The property was not worth the amount that we were charged based on how clean and undated other properties. I will not be starting there again"
Reviewed on Aug 3, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$285 nightly
The price is $328 total per night from Sep 1 to Sep 2
$328 total
Sep 1 - Sep 2
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $269 total per night from Sep 1 to Sep 2
$269 total
Sep 1 - Sep 2
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $303 total per night from Sep 2 to Sep 3
$303 total
Sep 2 - Sep 3
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a hot tub are all featured at this smoke-free resort. Traveling for business? Take advantage of the business center, ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Otay Mesa hotel reviews by fellow wanderers
Wyndham San Diego Bayside
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Loved it! Close to everything we needed!"
A verified traveler stayed at Wyndham San Diego Bayside
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