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Top hotels in Otay Mesa

Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
$206 nightly
The price is $237 total per night from Jun 29 to Jun 30
$237 total
Jun 29 - Jun 30
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
"Great views. Food was great!"

Reviewed on Jun 23, 2026

Opens in a new windowBay Club Hotel & Marina
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$273 nightly
The price is $317 total per night from Jul 1 to Jul 2
$317 total
Jul 1 - Jul 2
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"There was only one of two pools available"

Reviewed on Jun 23, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$225 nightly
The price is $261 total per night from Jun 25 to Jun 26
$261 total
Jun 25 - Jun 26
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Everything was amazing & I will be back soon!! Thank you guys for everything & making everything simple & just absolutely wonderful. Staff was friendly & helpful"

Reviewed on Jun 24, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$325 nightly
The price is $374 total per night from Jun 28 to Jun 29
$374 total
Jun 28 - Jun 29
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"Wonderful stay. The location was excellent, and the on site restaurants were a great convenience with good food and plenty of options. The staff was friendly, accommodating, and helpful throughout my stay. I would definitely return and recommend this property to others."

Reviewed on Jun 23, 2026

Opens in a new windowParadise Point Resort & Spa
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$338 nightly
The price is $388 total per night from Jun 30 to Jul 1
$388 total
Jun 30 - Jul 1
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a hot tub are all featured at this smoke-free resort. Spend a day at the beach surfing, or relax with free beach ...
"The room was clean and comfortable, the staff were helpful when checking in. The pool was a great amenity. The beach was right there to enjoy no matter where the room was at. Had restaurants on premises"

Reviewed on Jun 23, 2026

Opens in a new windowBahia Resort Hotel
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $157 total per night from Jun 29 to Jun 30
$157 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"When I booked I picked the premium queen suite. What was shown was NOT what we got. We couldn’t even watch the tv because it was on the wall beside the bed. While I understand you don’t always get what you see I expected to at least have a usable room. The ac did not keep up, even having it set at ..."

Reviewed on Jun 24, 2026

Opens in a new windowThe Sofia Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Jun 29 to Jun 30
$211 total
Jun 29 - Jun 30
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"This hotel is showing its age and smelled "musty." It clearly used to be very nice but is showing the signs of it being a while since it was built. Overall, a decent place to stay at a reasonable price point. The airport shuttle is a great amenity and the onsite restaurants were very good."

Reviewed on Jun 23, 2026

Opens in a new windowWyndham San Diego Bayside
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
$145 nightly
The price is $165 total per night from Jul 5 to Jul 6
$165 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"I've stayed here many times, and my coworkers all seem to have the same complaint: the hotel doesn't appear to invest enough in maintenance and upgrades. Many rooms have old refrigerators that make a lot of noise, and most of the bathroom toilets are very outdated. In some rooms, the toilet keeps ..."

Reviewed on Jun 24, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $133 total per night from Jul 6 to Jul 7
$133 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"Helpful and kind staff. The bathtub drained slowly. Other than that, this place was a great stay, and I recommend it for anyone looking for a decent-priced hotel in the San Diego area."

Reviewed on Jun 24, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

4 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Room was clean and intentionally designed. It was a tad smaller than anticipated and there is not much room for holding a wardrobe outside of open hanging closet. We needed up leaving most items within our luggage as we did not pack hangers. The bed was near the AC, so we were able to sleep well in a cold room. Walls are a bit thin and noise travels easily from those next door and above. The staff was friendly in our late check-in at 3am and accommodating for a delayed car parking pass."
A verified traveler stayed at The Alcala Hotel Mission Valley/Seaworld
The Alcala Hotel Mission Valley/Seaworld

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