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Hotels near Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel

2296 Niels Bohr Ct, San Diego, CA

Free Cancellation

2.52 mi from city center

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Quality Suites San Diego Otay Mesa

2351 Otay Center Dr, San Diego, CA

Free Cancellation

Reserve now, pay when you stay

2.33 mi from city center

This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 2 conference rooms, as well as the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like on-the-go breakfast and free self parking.

Wyndham San Diego Bayside

1355 N Harbor Drive, San Diego, CA

Free Cancellation

Reserve now, pay when you stay

15.47 mi from city center

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, express check-out, and free airport shuttle. There's a bar/lounge on site, and concierge services and free newspapers are also provided.

Manchester Grand Hyatt San Diego

1 Market Pl, San Diego, CA

Free Cancellation

14.87 mi from city center

This eco-friendly hotel features 6 restaurants, 2 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a poolside bar on site, and laundry facilities and concierge services are also provided.

Best Western Plus Marina Gateway Hotel

800 Bay Marina Dr, National City, CA

Free Cancellation

Reserve now, pay when you stay

9.98 mi from city center

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and perks like free self parking.

Legacy Resort Hotel & Spa

875 Hotel Circle South, San Diego, CA

Free Cancellation

Reserve now, pay when you stay

17.41 mi from city center

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 3 conference rooms, as well as the 24-hour business center and free WiFi in public areas. Self parking, a coffee shop, and a terrace are also offered.

Hard Rock Hotel San Diego

207 5th Ave, San Diego, CA

14.34 mi from city center

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. 2 coffee shops/cafés offer dining options, while a bar/lounge and a 24-hour gym are also on site.

Omni San Diego Hotel

675 L St, San Diego, CA

Free Cancellation

Reserve now, pay when you stay

14.3 mi from city center

The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 21 conference rooms, 24-hour business center, and valet parking. Enjoy the a rooftop terrace and perks like free WiFi.

Hilton San Diego Bayfront

1 Park Blvd, San Diego, CA

14.1 mi from city center

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Bring the family and enjoy the waterslide and kid-friendly dining. Relax with a drink at one of the 2 bars/lounges and get perks like free WiFi.

Hyatt Regency Mission Bay Spa and Marina

1441 Quivira Rd, San Diego, CA

Free Cancellation

20.48 mi from city center

A full-service spa, a marina, and 3 outdoor pools are all featured at this smoke-free resort. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a restaurant and a poolside bar for dining and drinks, and also a gym on site.

Humphreys Half Moon Inn

2303 Shelter Island Dr, San Diego, CA

Free Cancellation

Reserve now, pay when you stay

17.65 mi from city center

This smoke-free hotel features a nightclub, a marina, and a restaurant. Traveling on business? Take advantage of the business center and WiFi in public areas. Enjoy the outdoor pool and unwind at the bar/lounge and poolside bar.

Marriott Marquis San Diego Marina

333 W Harbor Dr, San Diego, CA

14.67 mi from city center

This smoke-free hotel features a full-service spa, a marina, and 3 restaurants. Families will appreciate the children's pool and onsite laundry facilities. Enjoy the 2 outdoor pools and perks like free WiFi.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.