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Top hotels in Otay Mesa West

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...
"Staff and amenities were nice. Was somewhat disappointed in the bed mattress. That mattress has seen its time and should be replaced"

Reviewed on Nov 3, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $269 total per night from Nov 29 to Nov 30
$269 total
Nov 29 - Nov 30
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"Rooms are really nice, private & comfortable. Pools & hot tubs are clean & nice. Very beautiful property with lots of amenities"

Reviewed on Nov 3, 2026

Opens in a new windowParadise Point Resort & Spa
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $146 total per night from Dec 3 to Dec 4
$146 total
Dec 3 - Dec 4
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
"There were just a couple of little things that kept us from giving 5 stars, the toilet paper roll kept coming off, the shower door would close on you. We had an issue with our blinds, but the maintenance staff came right up to fix it. It’s a great location, within walking distance to everywhere."

Reviewed on Nov 2, 2026

Opens in a new windowThe Sofia Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Clean room across from cruise ship terminal."

Reviewed on Nov 3, 2026

Opens in a new windowWyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$80 nightly
The price is $92 total per night from Dec 2 to Dec 3
$92 total
Dec 2 - Dec 3
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"Overall good hotel. We had 3 good nights in this hotel. The only issue that I can point out was that the windows are old and we could hear people talking next to our room all night. They were outside the hotel but it was loud so we woke up 2 times in the middle if the night. Everything else was ..."

Reviewed on Nov 3, 2026

Opens in a new windowHandlery Hotel
California Suites Hotel

California Suites Hotel

2 out of 5
5415 Clairemont Mesa Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $95 total per night from Dec 2 to Dec 3
$95 total
Dec 2 - Dec 3
Total with taxes and fees
This hotel features an outdoor pool and a hot tub. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference ...
"They need to change the shower head. The deadbolt lock isn't locking. The bed needs to be changed. When my partner is moving I can feel it like a wave."

Reviewed on Nov 2, 2026

Opens in a new windowCalifornia Suites Hotel
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Nov 4 to Nov 5
$97 total
Nov 4 - Nov 5
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
"Best non-resort hotel in SD."

Reviewed on Nov 2, 2026

Opens in a new windowBest Western Seven Seas
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Opens in a new windowSheraton San Diego Resort
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $92 total per night from Nov 17 to Nov 18
$92 total
Nov 17 - Nov 18
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa West Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa West area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa West to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa West are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa West hotel reviews by fellow wanderers

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Clean room across from cruise ship terminal."
A verified traveler stayed at Wyndham San Diego Bayside
Wyndham San Diego Bayside

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