Find a Hotel in Otay Mesa
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Top hotels in Otay Mesa

Pendry San Diego
Reviewed on Oct 15, 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Reviewed on Oct 18, 2025

Manchester Grand Hyatt San Diego
Reviewed on Oct 17, 2025

Hard Rock Hotel San Diego
Reviewed on Oct 18, 2025

Loews Coronado Bay Resort
Reviewed on Oct 17, 2025

Handlery Hotel
Reviewed on Oct 19, 2025

Wyndham San Diego Bayside
Reviewed on Oct 20, 2025

Hilton San Diego Mission Valley
Reviewed on Oct 20, 2025

Comfort Inn San Diego Airport At The Harbor
Reviewed on Oct 19, 2025
Otay Mesa Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Otay Mesa hotel reviews by fellow wanderers

Wyndham San Diego Bayside
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