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Top hotels in Otay Mesa

Loews Coronado Bay Resort

Loews Coronado Bay Resort

4 out of 5
4000 Coronado Bay Rd Coronado CA
$324 nightly
The price is $360 total per night from Aug 10 to Aug 11
$360 total
Aug 10 - Aug 11
Total with taxes and fees
A full-service spa, a marina, and 3 outdoor pools are all featured at this hotel. Take the free beach shuttle and relax with sun loungers and beach umbrellas. ...
"Everything was perfect"

Reviewed on Jul 20, 2026

Opens in a new windowLoews Coronado Bay Resort
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $265 total per night from Jul 27 to Jul 28
$265 total
Jul 27 - Jul 28
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Convenient location. Nice dining options"

Reviewed on Jul 20, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$311 nightly
The price is $358 total per night from Aug 16 to Aug 17
$358 total
Aug 16 - Aug 17
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"The staff was great. Other than that I’d never say here again. The first room was loud, smelly and very old. The second room was large but separated by a false wall so we heard everything the next room did. Including two screaming kids all night. Overall this place is very outdated and run down. ..."

Reviewed on Jul 20, 2026

Opens in a new windowParadise Point Resort & Spa
Hilton San Diego Bayfront

Hilton San Diego Bayfront

4 out of 5
1 Park Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$243 nightly
The price is $282 total per night from Aug 6 to Aug 7
$282 total
Aug 6 - Aug 7
Total with taxes and fees
This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Families will appreciate the children's pool and onsite laundry facilities. Enjoy the outdoor ...
"Dice que incluyen desayuno y no tiene disponibles ni una mesa de cafe"

Reviewed on Jul 20, 2026

Opens in a new windowHilton San Diego Bayfront
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Jul 28 to Jul 29
$211 total
Jul 28 - Jul 29
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
"Won’t be staying here again! Rooms definitely need to be updated. The rooms have carpet that is old so with the humidity all you smell is mildew. Our AC was only blowing warm air. I tried calling the front desk to get it fixed for over 40min with no answer. My husband had to walk down there to find ..."

Reviewed on Jul 20, 2026

Opens in a new windowWyndham San Diego Bayside
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$308 nightly
The price is $354 total per night from Aug 10 to Aug 11
$354 total
Aug 10 - Aug 11
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a hot tub are all featured at this smoke-free resort. Spend a day at the beach surfing, or relax with free beach ...
Opens in a new windowBahia Resort Hotel
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$213 nightly
The price is $245 total per night from Aug 3 to Aug 4
$245 total
Aug 3 - Aug 4
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
Opens in a new windowSheraton San Diego Resort
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $292 total per night from Aug 16 to Aug 17
$292 total
Aug 16 - Aug 17
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
Opens in a new windowThe Dana on Mission Bay
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $166 total per night from Aug 2 to Aug 3
$166 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

The Sofia Hotel

The Sofia Hotel

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Gorgeous room, stunning views. Would stay again!"
A verified traveler stayed at The Sofia Hotel
The Sofia Hotel

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