Find a Hotel in Otay Mesa

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top hotels in Otay Mesa

Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street, San Diego, CA
Fully refundableReserve now, pay when you stay
$300 nightly
The price is $348 total per night from Nov 20 to Nov 21
$348 total
Nov 20 - Nov 21
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"The room was perfect, the shower soap, and lotions smelled so good I bought some to take home. Beautiful hotel and easy to walk around gaslamp without need for uber. Walkable to train and trolly also! The hotel bar was very classy and staff went above and beyond!"

Reviewed on Oct 15, 2025

Opens in a new windowPendry San Diego
Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $140 total per night from Oct 27 to Oct 28
$140 total
Oct 27 - Oct 28
Total with taxes and fees
This hotel features an outdoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the hot tub and free buffet breakfast ...
"Homeless people around the front gates"

Reviewed on Oct 18, 2025

Opens in a new windowHampton Inn & Suites by Hilton San Diego SeaWorld
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
$286 nightly
The price is $332 total per night from Oct 29 to Oct 30
$332 total
Oct 29 - Oct 30
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"We had a studio suite on the 38th floor and the view was amazing. It was a nice, spacious room, but the bathroom was so tiny and the bed was not very comfortable. The bellman mentioned that there are upgrades planned in the near future though..."

Reviewed on Oct 17, 2025

Opens in a new windowManchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
$218 nightly
The price is $252 total per night from Nov 21 to Nov 22
$252 total
Nov 21 - Nov 22
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
"Clean rooms, great staf, convenient to restaurant's, ferry to coronado island and train system"

Reviewed on Oct 18, 2025

Opens in a new windowHard Rock Hotel San Diego
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4 out of 5
4000 Coronado Bay Rd, Coronado, CA
Fully refundableReserve now, pay when you stay
$240 nightly
The price is $266 total per night from Oct 26 to Oct 27
$266 total
Oct 26 - Oct 27
Total with taxes and fees
A full-service spa, a marina, and 3 outdoor pools are all featured at this hotel. Take the free beach shuttle and relax with sun loungers and beach umbrellas. ...
"Jade at the front desk was super friendly and by far the best interaction. She was great! We’ve stayed here several times in the past and were all great stays. This time I must say our room was not great. The bed and the bathroom was clean but other areas within the room were not. The floor definitely ..."

Reviewed on Oct 17, 2025

Opens in a new windowLoews Coronado Bay Resort
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
$112 nightly
The price is $129 total per night from Nov 11 to Nov 12
$129 total
Nov 11 - Nov 12
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
"Clean room awesome staff and quiet space"

Reviewed on Oct 19, 2025

Opens in a new windowHandlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $186 total per night from Oct 26 to Oct 27
$186 total
Oct 26 - Oct 27
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"Older property but great location. Friendly staff and lots nearby."

Reviewed on Oct 20, 2025

Opens in a new windowWyndham San Diego Bayside
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Oct 27 to Oct 28
$131 total
Oct 27 - Oct 28
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Something was going on at the hotel and it smelled like poop all over the place."

Reviewed on Oct 20, 2025

Opens in a new windowHilton San Diego Mission Valley
Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor

3.5 out of 5
San Diego
$83 nightly
The price is $94 total per night from Nov 11 to Nov 12
$94 total
Nov 11 - Nov 12
Total with taxes and fees
This hotel features an outdoor pool and a rooftop terrace. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free full breakfast ...
"Nice clean room. Everything was great."

Reviewed on Oct 19, 2025

Opens in a new windowComfort Inn San Diego Airport At The Harbor
Don't see what you're looking for?
See all available properties in Otay Mesa
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Otay Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Otay Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Otay Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Otay Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Otay Mesa hotel reviews by fellow wanderers

Wyndham San Diego Bayside

Wyndham San Diego Bayside

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Older property but great location. Friendly staff and lots nearby. "
A verified traveler stayed at Wyndham San Diego Bayside
Wyndham San Diego Bayside

Explore More Ways to Travel with Travelocity