Explore the best 2025 4 Star Hotels Hotels in Otay Mesa West
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Top Otay Mesa West 4 Star hotels

Manchester Grand Hyatt San Diego
1 Market Pl, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This eco-certified hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the hot tub and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub

Marriott Marquis San Diego Marina
333 W Harbor Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This smoke-free hotel features a full-service spa, a marina, and 5 restaurants. Families will appreciate the children's pool and onsite laundry facilities. Enjoy the 2 outdoor pools and perks like free WiFi.
Pool
Hot Tub

Embassy Suites by Hilton San Diego Bay Downtown
601 Pacific Hwy, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, express check-in, and valet parking. Enjoy the gym and free buffet breakfast each morning.
Pool
Breakfast included

DoubleTree by Hilton Hotel San Diego - Mission Valley
7450 Hazard Center Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 20 conference rooms, free WiFi in public areas, and express check-out. There's an indoor pool on site, and laundry facilities and wedding services are also offered.
Pool
Pet friendly

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, express check-out, and free airport shuttle. There's a bar/lounge on site, and concierge services and free newspapers are also provided.
Pool
Free airport shuttle

Sheraton Mission Valley San Diego Hotel
1433 Camino Del Rio S, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. There's a hot tub on site, and a 24-hour front desk and a terrace are also provided.
Pool
Hot Tub

Lafayette Hotel & Club
2223 El Cajon Blvd, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the outdoor pool and conveniences like a 24-hour front desk and concierge services.
Pool
Pet friendly

Palihotel San Diego Gaslamp Quarter
830 Sixth Avenue, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and dry cleaning are also offered.
Pet friendly
Free WiFi

Sheraton San Diego Resort
1380 Harbor Island Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. Enjoy the 2 hot tubs, and relax with drinks at the bar/lounge and poolside bar.
Pool
Hot Tub

Hard Rock Hotel San Diego
207 5th Ave, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free WiFi. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.
Pool
Free WiFi

Hilton San Diego Bayfront
1 Park Blvd, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Bring the family and enjoy the children's pool and kid-friendly dining. Relax with a drink at one of the 2 bars/lounges and get perks like free WiFi.
Pool
Hot Tub

Hilton San Diego Mission Valley
901 Camino Del Rio S, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. There's a 24-hour gym on site, and laundry facilities and concierge services are also offered.
Pool
Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa West hotels essential information
Accommodation | 6,491 hotels |
---|---|
Lowest Price | |
Highest Price | |
Popular hotels | Manchester Grand Hyatt San Diego, Marriott Marquis San Diego Marina, Embassy Suites by Hilton San Diego Bay Downtown, DoubleTree by Hilton Hotel San Diego - Mission Valley, Wyndham San Diego Bayside, Sheraton Mission Valley San Diego Hotel, Lafayette Hotel & Club, Palihotel San Diego Gaslamp Quarter, Sheraton San Diego Resort, Hard Rock Hotel San Diego, Hilton San Diego Bayfront, Hilton San Diego Mission Valley |
Recent Otay Mesa West hotel reviews by fellow wanderers

The Dana on Mission Bay
5 out of 5
Posted 11 hours ago
Travelocity Verified Review
"Very calm and peaceful stay!"
A verified traveler stayed at The Dana on Mission Bay
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