Explore top 2026 4 Star Hotels in South San Diego

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Top South San Diego 4 Star hotels

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$266 nightly
The price is $308 total per night from Apr 15 to Apr 16
$308 total
Apr 15 - Apr 16
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
9/10 Wonderful! (3,543 reviews)
The hotel was very nice. The only negative, is that the hotel is starting to show it's age.

Reviewed on Apr 13, 2026

Opens in a new windowHard Rock Hotel San Diego
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$276 nightly
The price is $320 total per night from May 7 to May 8
$320 total
May 7 - May 8
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (2,875 reviews)
Great location

Reviewed on Apr 12, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$235 nightly
The price is $270 total per night from May 10 to May 11
$270 total
May 10 - May 11
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
8.8/10 Excellent! (2,547 reviews)
Overall a nice place but the room could have been cleaner. Probably would not recommend with babies and toddlers

Reviewed on Apr 13, 2026

Opens in a new windowParadise Point Resort & Spa
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd San Diego CA
Fully refundableReserve now, pay when you stay
$215 nightly
The price is $247 total per night from May 10 to May 11
$247 total
May 10 - May 11
Total with taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,618 reviews)
Pools are small and not enough chairs to relax

Reviewed on Apr 13, 2026

Opens in a new windowHyatt Regency Mission Bay Spa and Marina
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from May 3 to May 4
$211 total
May 3 - May 4
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
8.4/10 Very Good! (6,163 reviews)
Had a great stay at the Wyndham San Diego Bayside. Super convenient location by the water—easy walk to lots of good food spots. The room was clean, comfy, and the bay view was a nice bonus. Staff were friendly and made everything smooth. Would definitely stay here again!

Reviewed on Apr 13, 2026

Opens in a new windowWyndham San Diego Bayside
San Diego Marriott Gaslamp Quarter

San Diego Marriott Gaslamp Quarter

4 out of 5
660 K St San Diego CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $196 total per night from May 10 to May 11
$196 total
May 10 - May 11
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, express ...
8.8/10 Excellent! (1,668 reviews)
Every interaction with every staff member was friendly, helpful, and absolutely wonderful. Best hotel experience ever!

Reviewed on Apr 12, 2026

Opens in a new windowSan Diego Marriott Gaslamp Quarter
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $286 total per night from Apr 16 to Apr 17
$286 total
Apr 16 - Apr 17
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
9.2/10 Wonderful! (1,585 reviews)
If tranquility is what you looking for i would say this is not the place..this is a party hotel so if thats what you looking for then this is the place

Reviewed on Apr 13, 2026

Opens in a new windowLafayette Hotel & Club
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$191 nightly
The price is $220 total per night from May 3 to May 4
$220 total
May 3 - May 4
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
8.4/10 Very Good! (3,474 reviews)
My stay here was amazing the staff was nice and attentive, room was clean with an amazing view. Next time we will stay on the marina side although the bay view was peaceful and beautiful I believe it’s more restaurants to choose from. I definitely plan to stay here again!

Reviewed on Apr 13, 2026

Opens in a new windowSheraton San Diego Resort
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

4 out of 5
675 L St San Diego CA
Fully refundableReserve now, pay when you stay
$289 nightly
The price is $335 total per night from Apr 15 to Apr 16
$335 total
Apr 15 - Apr 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9.2/10 Wonderful! (2,146 reviews)
Room was perfectly fine and very clean and the view was really nice. The bridge to Petco Park is amazing and really the reason you would stay here unless here for a conference. My only knock in star ratings is really due to the lady at check in who wasn’t friendly. Room wasn’t ready until 4 which ...

Reviewed on Apr 13, 2026

Opens in a new windowOmni San Diego Hotel at the Ballpark
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$245 nightly
The price is $282 total per night from May 10 to May 11
$282 total
May 10 - May 11
Total with taxes and fees
A full-service spa, 2 restaurants, and 5 outdoor tennis courts are all featured at this Mediterranean resort. There's fun for all ages with a children's pool ...
8.4/10 Very Good! (1,405 reviews)
Activities for all ages. Restaurants were good but pricey. The scheduled events like movie night and smores were a letdown, felt cheap and forgettable. Room was okay but there was a leftover sock and toy from previous people when we got there and a strange clicking sound in the bathroom every 20 ...

Reviewed on Apr 13, 2026

Opens in a new windowSan Diego Mission Bay Resort
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4 Star Hotels South San Diego

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in South San Diego 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in South San Diego will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in South San Diego, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

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