Find and compare 3 Star hotels in Otay Mesa

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29

Top Otay Mesa 3 Star hotels

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $95 total per night from Dec 15 to Dec 16
$95 total
Dec 15 - Dec 16
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Opens in a new windowHandlery Hotel
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $179 total per night from Nov 16 to Nov 17
$179 total
Nov 16 - Nov 17
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Opens in a new windowBay Club Hotel & Marina
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $97 total per night from Nov 16 to Nov 17
$97 total
Nov 16 - Nov 17
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
Opens in a new windowBest Western Seven Seas
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $97 total per night from Nov 29 to Nov 30
$97 total
Nov 29 - Nov 30
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
8/10 Very Good! (3,185 reviews)
"Once again I was given a handicap room when I did not request one"

Reviewed on Nov 15, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo

3 out of 5
1201 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $89 total per night from Dec 15 to Dec 16
$89 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the hot tub and perks like free WiFi. A coffee shop, a snack bar/deli, and a picnic ...
8.2/10 Very Good! (1,914 reviews)
"the hotel is consistently comfortable, accomodating and pleasant"

Reviewed on Nov 14, 2026

Opens in a new windowThe Atwood Hotel San Diego - SeaWorld/Zoo
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

3.5 out of 5
2270 Hotel Cir N San Diego CA
Fully refundable
$110 nightly
The price is $127 total per night from Nov 30 to Dec 1
$127 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
8.4/10 Very Good! (1,518 reviews)
"As expected per reviews"

Reviewed on Nov 15, 2026

Opens in a new windowCrowne Plaza San Diego - Mission Valley by IHG
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$194 nightly
The price is $223 total per night from Nov 17 to Nov 18
$223 total
Nov 17 - Nov 18
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
9/10 Wonderful! (4,497 reviews)
"Great location, very walkable, nice updated rooms, on-site restaurant was delicious, pools were clean and rental shed had bikes, kayaks, seadoos, etc. would stay here again."

Reviewed on Nov 15, 2026

Opens in a new windowThe Dana on Mission Bay
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 out of 5
800 Bay Marina Dr National City CA
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $138 total per night from Nov 22 to Nov 23
$138 total
Nov 22 - Nov 23
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Bring the family and enjoy the mini golf, children's pool, and kid-friendly ...
Opens in a new windowBest Western Plus Marina Gateway Hotel
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

3 out of 5
3737 Sports Arena Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $110 total per night from Nov 22 to Nov 23
$110 total
Nov 22 - Nov 23
Total with taxes and fees
An outdoor pool, self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. Traveling on business? Take advantage of the ...
Opens in a new windowWyndham Garden San Diego Near SeaWorld
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $147 total per night from Nov 22 to Nov 23
$147 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
Don't see what you're looking for?
See all available properties in Otay Mesa
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Otay Mesa hotel reviews by fellow wanderers

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

4 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Very good breakfast and clean room."
A verified traveler stayed at The Alcala Hotel Mission Valley/Seaworld
The Alcala Hotel Mission Valley/Seaworld

Explore More Ways to Travel with Travelocity