Explore top 2026 4 Star Hotels in Central San Diego

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Top Central San Diego 4 Star hotels

Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $286 total per night from Mar 23 to Mar 24
$286 total
Mar 23 - Mar 24
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
9.2/10 Wonderful! (1,534 reviews)
Stunning place especially if you’re a fan of the great gastby!..

Reviewed on Mar 20, 2026

Opens in a new windowLafayette Hotel & Club
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4 out of 5
875 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $240 total per night from Apr 5 to Apr 6
$240 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (2,942 reviews)
Very nice hotel

Reviewed on Mar 20, 2026

Opens in a new windowLegacy Resort Hotel & Spa
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4 out of 5
7450 Hazard Center Dr San Diego CA
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Apr 5 to Apr 6
$131 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 20 conference rooms, free WiFi in public areas, ...
8.4/10 Very Good! (1,566 reviews)
Ordered a cesar salad and received whole uncut leaves of lettuce which was weird.

Reviewed on Mar 16, 2026

Opens in a new windowDoubleTree by Hilton Hotel San Diego - Mission Valley
San Diego Marriott La Jolla

San Diego Marriott La Jolla

4 out of 5
4240 La Jolla Village Dr La Jolla CA
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $217 total per night from Apr 4 to Apr 5
$217 total
Apr 4 - Apr 5
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.6/10 Excellent! (2,289 reviews)
Everything was really clean and it’s in a great location and the stuff are very friendly.

Reviewed on Mar 18, 2026

Opens in a new windowSan Diego Marriott La Jolla
San Diego Marriott Mission Valley

San Diego Marriott Mission Valley

4 out of 5
8757 Rio San Diego Dr San Diego CA
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $171 total per night from Apr 5 to Apr 6
$171 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 30 conference rooms, business center, and express ...
8.8/10 Excellent! (1,004 reviews)
The San Diego Marriott Mission Valley is an excellent place to stay. Many amenities, wonderful staff, and convenient walking to shops.

Reviewed on Mar 19, 2026

Opens in a new windowSan Diego Marriott Mission Valley
Hyatt Regency La Jolla

Hyatt Regency La Jolla

4 out of 5
3777 La Jolla Village Drive San Diego CA
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $216 total per night from Apr 5 to Apr 6
$216 total
Apr 5 - Apr 6
Total with taxes and fees
2 outdoor tennis courts, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
8.8/10 Excellent! (1,003 reviews)
Beautiful property. Clean rooms and great location! Will definitely stay at this location again!

Reviewed on Mar 17, 2026

Opens in a new windowHyatt Regency La Jolla
Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel

4 out of 5
1433 Camino Del Rio S San Diego CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $155 total per night from Mar 29 to Mar 30
$155 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
8.6/10 Excellent! (1,711 reviews)
next to the highway and it is a bit noisy even we are 10+ floor

Reviewed on Mar 20, 2026

Opens in a new windowSheraton Mission Valley San Diego Hotel
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $151 total per night from Apr 4 to Apr 5
$151 total
Apr 4 - Apr 5
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8/10 Very Good! (2,371 reviews)
Very good view

Reviewed on Mar 20, 2026

Opens in a new windowHilton San Diego Mission Valley
Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla

4 out of 5
4550 La Jolla Village Dr San Diego CA
Fully refundableReserve now, pay when you stay
$202 nightly
The price is $232 total per night from Mar 29 to Mar 30
$232 total
Mar 29 - Mar 30
Total with taxes and fees
This traditional hotel includes 2 restaurants, an indoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and WiFi in ...
8.8/10 Excellent! (1,889 reviews)
Our room was not clean. There were all of these hidden fees when we arrived. When I booked on Expedia it claimed all fees were included but when I arrived we were charged 45 dollars a day for parking and had to sounds minimum of 20 dollars a day at the hotel. This was not disclosed prior. I was over ...

Reviewed on Mar 18, 2026

Opens in a new windowEmbassy Suites by Hilton San Diego La Jolla
Town and Country San Diego

Town and Country San Diego

4 out of 5
500 Hotel Circle North San Diego CA
Fully refundableReserve now, pay when you stay
$227 nightly
The price is $261 total per night from Mar 27 to Mar 28
$261 total
Mar 27 - Mar 28
Total with taxes and fees
This hotel features 2 restaurants, 2 outdoor pools, and a hot tub. Bring the family and enjoy the children's pool, waterslide, and playground. Enjoy the gym ...
8.6/10 Excellent! (1,389 reviews)
The cutest hotel ever! Everyone was nice and it was super clean

Reviewed on Mar 18, 2026

Opens in a new windowTown and Country San Diego
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4 Star Hotels Central San Diego

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Central San Diego 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Central San Diego will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Central San Diego, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Central San Diego hotel reviews by fellow wanderers

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