Explore top 2026 4 Star Hotels in Otay Mesa West
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Top Otay Mesa West 4 Star hotels

Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$237 nightly
The price is $274 total per night from Apr 5 to Apr 6
$274 total
Apr 5 - Apr 6
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
9/10 Wonderful! (3,419 reviews)
Pool seating was less than expected during a holiday weekend. Only water fountain refill station was in the gym.
Reviewed on Mar 15, 2026

Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $274 total per night from Apr 2 to Apr 3
$274 total
Apr 2 - Apr 3
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (2,900 reviews)
Perfect service
Reviewed on Mar 13, 2026

Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$273 nightly
The price is $314 total per night from Apr 5 to Apr 6
$314 total
Apr 5 - Apr 6
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
8.6/10 Excellent! (2,454 reviews)
Dog track of a hotel. Not sure how this is rated 4 stars. Old run down rooms that smell like mildew, things falling apart, rust, and damaged.
Reviewed on Mar 15, 2026

Hyatt Regency Mission Bay Spa and Marina
1441 Quivira Rd San Diego CA
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $248 total per night from Apr 5 to Apr 6
$248 total
Apr 5 - Apr 6
Total with taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,607 reviews)
The view was fantastic. Room had black mold above the bathroom light that had been broken and not fixed before our stay. Staff offered upgrade for our honeymoon then mentioned it was an upcharge. The ice machine outside our room was broken and I could hear it malfunctioning all night. There was a ...
Reviewed on Mar 15, 2026

Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Mar 19 to Mar 20
$211 total
Mar 19 - Mar 20
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
8.4/10 Very Good! (6,056 reviews)
Excellent hotel right next to cruise ship pier. Couldn't have had a better experience. Staff was very helpful and friendly.
Reviewed on Mar 15, 2026

San Diego Marriott Gaslamp Quarter
660 K St San Diego CA
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $186 total per night from Apr 2 to Apr 3
$186 total
Apr 2 - Apr 3
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, express ...
8.8/10 Excellent! (1,670 reviews)
The staff was fantastic. Definitely the highlight of the stay. The rooms are very old in need of significant upgrades and the king suite isn't worth staying in. The jr king suite is much better.
Reviewed on Mar 15, 2026

Lafayette Hotel & Club
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $286 total per night from Mar 19 to Mar 20
$286 total
Mar 19 - Mar 20
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
9.2/10 Wonderful! (1,526 reviews)
Hell yeah
Reviewed on Mar 15, 2026

Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$163 nightly
The price is $188 total per night from Apr 1 to Apr 2
$188 total
Apr 1 - Apr 2
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
8.4/10 Very Good! (3,378 reviews)
Excelent
Reviewed on Mar 15, 2026

Omni San Diego Hotel at the Ballpark
675 L St San Diego CA
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $271 total per night from Apr 3 to Apr 4
$271 total
Apr 3 - Apr 4
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9.2/10 Wonderful! (2,082 reviews)
Really enjoyed our stay there 😍
Reviewed on Mar 15, 2026

San Diego Mission Bay Resort
1775 E Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$285 nightly
The price is $328 total per night from Apr 5 to Apr 6
$328 total
Apr 5 - Apr 6
Total with taxes and fees
A full-service spa, 2 restaurants, and 5 outdoor tennis courts are all featured at this Mediterranean resort. There's fun for all ages with a children's pool ...
8.4/10 Very Good! (1,373 reviews)
Will definitely come back
Reviewed on Mar 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Otay Mesa West hotel reviews by fellow wanderers

The Sofia Hotel
4 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Beds way to small!!!!"
A verified traveler stayed at The Sofia Hotel
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