Explore top 2026 4 Star Hotels in Otay Mesa West

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Top Otay Mesa West 4 Star hotels

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$256 nightly
The price is $297 total per night from May 21 to May 22
$297 total
May 21 - May 22
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (2,834 reviews)
The staff were extremely helpful. I loved the room and the view was absolutely amazing, I would say that was my favorite part! Parking is connected to the building and the gift shop had essentials that you may have forgotten. There’s a Starbucks connected to the hotel as well😊. I would 100% come ...

Reviewed on May 13, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $235 total per night from May 25 to May 26
$235 total
May 25 - May 26
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
9/10 Wonderful! (3,660 reviews)
Always fun always friendly staff stayed here a few times always great

Reviewed on May 14, 2026

Opens in a new windowHard Rock Hotel San Diego
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

4 out of 5
675 L St San Diego CA
Fully refundableReserve now, pay when you stay
$208 nightly
The price is $241 total per night from May 25 to May 26
$241 total
May 25 - May 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9.2/10 Wonderful! (2,186 reviews)
Very nice hotel, adjoining Padres' Petco park. Easy access to front desk, bar, coffee area. Didn't try food...plenty of restaurants and bars a short walk away. Only negative preventing us from returning is $70 a night parking....exhorbitant on top of $300 + nightly rate

Reviewed on May 15, 2026

Opens in a new windowOmni San Diego Hotel at the Ballpark
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $201 total per night from May 25 to May 26
$201 total
May 25 - May 26
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
8.4/10 Very Good! (6,135 reviews)
The location is great. We've been staying there regularly for three years, and it's gone downhill. It's not property maintained. The refrigerator was leaking through the cabinet and onto the carpet. The carpet was so dirty, it turned the soles of our feet black. Worst of all they now have a $30/day ...

Reviewed on May 15, 2026

Opens in a new windowWyndham San Diego Bayside
San Diego Marriott Gaslamp Quarter

San Diego Marriott Gaslamp Quarter

4 out of 5
660 K St San Diego CA
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $186 total per night from May 21 to May 22
$186 total
May 21 - May 22
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, express ...
8.8/10 Excellent! (1,668 reviews)
Amazing place will stay there again

Reviewed on May 14, 2026

Opens in a new windowSan Diego Marriott Gaslamp Quarter
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd San Diego CA
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $254 total per night from May 20 to May 21
$254 total
May 20 - May 21
Total with taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,638 reviews)
This property is simply amazing, from the ambiance, to the amenities, and the staff…just terrific. The heated pool and the poolside restaurant are great.

Reviewed on May 13, 2026

Opens in a new windowHyatt Regency Mission Bay Spa and Marina
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $194 total per night from May 24 to May 25
$194 total
May 24 - May 25
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
8.4/10 Very Good! (3,527 reviews)
Helpful staff

Reviewed on May 14, 2026

Opens in a new windowSheraton San Diego Resort
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

4 out of 5
601 Pacific Hwy San Diego CA
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $235 total per night from May 28 to May 29
$235 total
May 28 - May 29
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, express check-in, and valet ...
9/10 Wonderful! (1,766 reviews)
Everything went smoothly guest services handled everything perfectly !

Reviewed on May 15, 2026

Opens in a new windowEmbassy Suites by Hilton San Diego Bay Downtown
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$264 nightly
The price is $303 total per night from May 25 to May 26
$303 total
May 25 - May 26
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
8.8/10 Excellent! (2,581 reviews)
Good

Reviewed on May 14, 2026

Opens in a new windowParadise Point Resort & Spa
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $286 total per night from May 18 to May 19
$286 total
May 18 - May 19
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
9.4/10 Exceptional! (1,647 reviews)
Just one of my favorites hotels ever..that is all.

Reviewed on May 14, 2026

Opens in a new windowLafayette Hotel & Club
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