Explore top 2026 4 Star Hotels in Otay Mesa West

Name: Lafayette Hotel & Club
Price range: $286 total
Rating: 9.4

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Top Otay Mesa West 4 Star hotels

Hard Rock Hotel San Diego

207 5th Ave San Diego CA

Fully refundableReserve now, pay when you stay

$203 nightly

$235 total

May 10 - May 11

Total with taxes and fees

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...

9/10 Wonderful! (3,649 reviews)

Love it

Reviewed on May 8, 2026

Hotel del Coronado, Curio Collection by Hilton

1500 Orange Ave Coronado CA

Fully refundableReserve now, pay when you stay

$576 nightly

$640 total

May 25 - May 26

Total with taxes and fees

A private beach, 6 restaurants, and an outdoor pool are all featured at this Victorian resort. Relax with sun loungers and beach umbrellas, and cool off with ...

8.6/10 Excellent! (1,010 reviews)

Amzing work on the remodel! Alot of nice places to est and hangout! Super friendly staff and clean amenities

Reviewed on May 9, 2026

Omni San Diego Hotel at the Ballpark

675 L St San Diego CA

$208 nightly

$241 total

May 10 - May 11

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (2,168 reviews)

Convenient location, great amenities and wonderful staff… close to so many attractions

Reviewed on May 8, 2026

Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA

Fully refundableReserve now, pay when you stay

$182 nightly

$211 total

May 13 - May 14

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...

8.4/10 Very Good! (6,183 reviews)

Terrible experience. Hotel is in very bad shape. I was glad to leave. It seems that the owners have the property in a death spiral where they let the property deteriorate while still getting income from the one-and-done guests, cruise ship guests who can walk to the dock, airline staff contracts, ...

Reviewed on May 8, 2026

Hyatt Regency Mission Bay Spa and Marina

1441 Quivira Rd San Diego CA

Fully refundableReserve now, pay when you stay

$215 nightly

$247 total

May 10 - May 11

Total with taxes and fees

This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.4/10 Very Good! (1,631 reviews)

Restaurants aren’t that great

Reviewed on May 6, 2026

San Diego Marriott Mission Valley

8757 Rio San Diego Dr San Diego CA

$164 nightly

$189 total

May 17 - May 18

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 30 conference rooms, business center, and express ...

8.8/10 Excellent! (1,006 reviews)

They need to update on the hot tub since they no longer had it.

Reviewed on May 7, 2026

Sheraton San Diego Resort

1380 Harbor Island Dr San Diego CA

Fully refundableReserve now, pay when you stay

$169 nightly

$194 total

May 25 - May 26

Total with taxes and fees

A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...

8.4/10 Very Good! (3,528 reviews)

Really bad, dissapointing.

Reviewed on May 8, 2026

San Diego Marriott Gaslamp Quarter

660 K St San Diego CA

Fully refundableReserve now, pay when you stay

$152 nightly

$176 total

May 10 - May 11

Total with taxes and fees

A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, express ...

8.8/10 Excellent! (1,672 reviews)

My only complaint is that the shower gel in the shower was empty.

Reviewed on May 9, 2026

Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA

Fully refundableReserve now, pay when you stay

$220 nightly

$253 total

May 10 - May 11

Total with taxes and fees

This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...

8.8/10 Excellent! (2,584 reviews)

Room was cl

Reviewed on May 8, 2026

Lafayette Hotel & Club

2223 El Cajon Blvd San Diego CA

Fully refundableReserve now, pay when you stay

$249 nightly

$286 total

May 11 - May 12

Total with taxes and fees

This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...

9.4/10 Exceptional! (1,639 reviews)

The rooms were clean and colorful

Reviewed on May 8, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Otay Mesa West hotel reviews by fellow wanderers

Best Western Seven Seas

4 out of 5

Posted 2 hours ago

Travelocity Verified Review

"The pool was great. The restaurant was the definition of fine, not great, not bad. The prices were pretty ridiculous. $5 for a tea or coffee is insane. Staff was attentive and responsive. "

A verified traveler stayed at Best Western Seven Seas