Book Hotels in Effingham, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Effingham hotels

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Fully refundable
$89 nightly
The price is $100 total per night from Sep 20 to Sep 21
$100 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free ...
"Breakfast and coffee need improvement."

Reviewed on Sep 10, 2026

Opens in a new windowPark Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $72 total per night from Sep 13 to Sep 14
$72 total
Sep 13 - Sep 14
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"The hotel feels dingy and outdated. The location was excellent to go to the races at Darlington"

Reviewed on Sep 10, 2026

Opens in a new windowHoward Johnson by Wyndham Florence
SpringHill Suites by Marriott Florence

SpringHill Suites by Marriott Florence

3 out of 5
2670 Hospitality Blvd Florence SC
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $122 total per night from Sep 20 to Sep 21
$122 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free continental ...
"We had a problem with a TV and refrigerator in one of our two rooms. The staff was excellent and replaced the items immediately so that the rest of our stay was good. The housekeeping staff was great. The desk staff and maintenance were great. The breakfast had a good selection and was good. There ..."

Reviewed on Sep 8, 2026

Opens in a new windowSpringHill Suites by Marriott Florence
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $95 total per night from Oct 4 to Oct 5
$95 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Good value for quick stop on Florence, SC"

Reviewed on Sep 10, 2026

Opens in a new windowSpark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $72 total per night from Sep 13 to Sep 14
$72 total
Sep 13 - Sep 14
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"The facility looked run down. Got in the room and was not clean the curtain was falling down. The floors LVP flooring was curling up the paint on the back of the bathroom door was peeling off and the door would not close properly. The TV channels where all in spanish had to get that fixed as well. ..."

Reviewed on Sep 10, 2026

Opens in a new windowDays Inn by Wyndham Florence Near Civic Center
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Sep 20 to Sep 21
$100 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Opens in a new windowQuality Inn & Suites Florence Civic Center
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Fully refundable
$105 nightly
The price is $118 total per night from Oct 4 to Oct 5
$118 total
Oct 4 - Oct 5
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Opens in a new windowComfort Inn & Suites Florence Center Area
The Inn at the Crossroads

The Inn at the Crossroads

2 out of 5
128 West Main Street Lake City SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $113 total per night from Sep 16 to Sep 17
$113 total
Sep 16 - Sep 17
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowThe Inn at the Crossroads
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $123 total per night from Oct 1 to Oct 2
$123 total
Oct 1 - Oct 2
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowHyatt Place Florence Downtown
Don't see what you're looking for?
See all available properties in Effingham
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Effingham?
Family getaways are where treasured memories are made, but it's no secret that traveling with little ones can be tricky. These kid-friendly Effingham hotels come with perks designed to keep visitors of all ages relaxed and happy: Put your bags down at Cheerful home with plenty of privacy and entertainment room.. It comes with a fireplace, free WiFi and a knack for making families feel welcome. Otherwise, spend your Effingham break at Walking distance from one of South Carolinas top Medical centers.. Take advantage of free WiFi, clothes washing facilities and more here.
Where can I find cheap hotels in Effingham?
At Travelocity you'll find really nice hotels in Effingham at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Effingham rather than in Effingham. We may find you even better rates, too.
How do I find the best Effingham hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Effingham then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Effingham?
The cheapest hotel in Effingham is $72. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Effingham?
There are 161 hotels in Effingham on Travelocity.
What are the best hotels in Effingham?
Effingham has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Effingham for you!
When is the best time to visit Effingham?
If you want the joy of a fun-filled trip in peak season, visit Effingham during March, April and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and October.
When is the cheapest time to stay in Effingham?
Based on historic data is usually the cheapest month to visit Effingham. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Effingham?
There are multiple hotels in Effingham that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Effingham. We have plenty of kid-friendly hotels in Effingham to choose from on Travelocity!
Why book a hotel in Effingham through Travelocity?
Because we have the top hotels in Effingham! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Effingham on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Effingham hotel reviews by fellow wanderers

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

4 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Breakfast and coffee need improvement."
A verified traveler stayed at Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SC

Explore More Ways to Travel with Travelocity