Book Hotels in Effingham, SC

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Top Effingham hotels

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Jan 18 to Jan 19
$110 total
Jan 18 - Jan 19
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Very clean

Reviewed on Dec 27, 2025

Opens in a new windowComfort Inn & Suites Florence Center Area
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

2.5 out of 5
3000 W Radio Dr Florence SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Jan 25 to Jan 26
$109 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
Staff was great room was what was expected

Reviewed on Dec 29, 2025

Opens in a new windowHampton Inn & Suites Florence Center
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Fully refundable
$85 nightly
The price is $95 total per night from Jan 4 to Jan 5
$95 total
Jan 4 - Jan 5
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Business travelers can take advantage of the business center. Enjoy ...
Room was comfortable, breakfast was fine, felt safe

Reviewed on Dec 27, 2025

Opens in a new windowPark Inn by Radisson Florence, SC
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $112 total per night from Jan 12 to Jan 13
$112 total
Jan 12 - Jan 13
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Clean rooms, very convenient location, parking nearby. Very courteous staff.

Reviewed on Dec 24, 2025

Opens in a new windowHyatt Place Florence Downtown
Residence Inn Marriott Florence

Residence Inn Marriott Florence

3 out of 5
2660 Hospitality Blvd Florence SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $111 total per night from Jan 5 to Jan 6
$111 total
Jan 5 - Jan 6
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free continental ...
Staff was very friendly The room Is spacious and very clean . There is plenty of green space outside for our dog !

Reviewed on Dec 27, 2025

Opens in a new windowResidence Inn Marriott Florence
TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence

3 out of 5
2650 Hospitality Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $116 total per night from Jan 4 to Jan 5
$116 total
Jan 4 - Jan 5
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Room was pretty clean, and in good shape. But the rowdy guess made it a little bit of a challenging experience. HOTEL staff all were very friendly and kind.

Reviewed on Dec 21, 2025

Opens in a new windowTownePlace Suites by Marriott Florence
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Jan 2 to Jan 3
$79 total
Jan 2 - Jan 3
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Good value for the price: nicely-appointed room; clean bathroom and shower; pleasant environment for a lovely continental breakfast. Would definitely return to this hotel.

Reviewed on Dec 26, 2025

Opens in a new windowHoward Johnson by Wyndham Florence
Tru by Hilton Florence I-95

Tru by Hilton Florence I-95

2.5 out of 5
2140 West Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $108 total per night from Jan 7 to Jan 8
$108 total
Jan 7 - Jan 8
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Relax with a drink ...
Room was clean &comfortable. Staff was friendly, and treated us great. Only shortcomings was the breakfast, not much to choose from, pancake maker was not working, grits were lumpy and dry. To be fair, it was Christmas morning and toward the end of breakfast time.

Reviewed on Dec 26, 2025

Opens in a new windowTru by Hilton Florence I-95
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Jan 12 to Jan 13
$105 total
Jan 12 - Jan 13
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Nice rooms, clean bathrooms. The room location (first floor, near back door) was perfect. The floor in our room was a bit "sticky" and when got into the shower this morning, we noticed the bottom of our feet had gotten dirty just walking in the room.

Reviewed on Dec 26, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham Florence
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Effingham?
Family getaways are where treasured memories are made, but it's no secret that traveling with little ones can be tricky. These kid-friendly Effingham hotels come with perks designed to keep visitors of all ages relaxed and happy: Put your bags down at Cheerful home with plenty of privacy and entertainment room.. It comes with a fireplace, free WiFi and a knack for making families feel welcome. Otherwise, spend your Effingham break at Walking distance from one of South Carolinas top Medical centers.. Take advantage of free WiFi, clothes washing facilities and more here.
Where can I find cheap hotels in Effingham?
At Travelocity you'll find really nice hotels in Effingham at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Effingham rather than in Effingham. We may find you even better rates, too.
How do I find the best Effingham hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Effingham then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Effingham?
The cheapest hotel in Effingham is $79. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Effingham?
There are 137 hotels in Effingham on Travelocity.
What are the best hotels in Effingham?
Effingham has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Effingham for you!
When is the best time to visit Effingham?
If you want the joy of a fun-filled trip in peak season, visit Effingham during March, April and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and October.
When is the cheapest time to stay in Effingham?
Based on historic data is usually the cheapest month to visit Effingham. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Effingham?
There are multiple hotels in Effingham that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Effingham. We have plenty of kid-friendly hotels in Effingham to choose from on Travelocity!
Why book a hotel in Effingham through Travelocity?
Because we have the top hotels in Effingham! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Effingham on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Effingham hotel reviews by fellow wanderers

Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Staff was great room was what was expected "
A verified traveler stayed at Hampton Inn & Suites Florence Center
Hampton Inn & Suites Florence Center

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