Book Hotels in Pamplico, SC
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Top Pamplico hotels

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
3440 W Radio Dr Florence SC
Fully refundable
$118 nightly
The price is $132 total per night from Apr 5 to Apr 6
$132 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Clean room, easy parking, great breakfast
Reviewed on Mar 15, 2026

Comfort Inn & Suites Florence Center Area
527 Woody Jones Blvd Florence SC
Fully refundable
$102 nightly
The price is $114 total per night from Apr 26 to Apr 27
$114 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Property was acceptable for our standards.
Reviewed on Mar 26, 2026

Hyatt Place Florence Downtown
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $137 total per night from Apr 5 to Apr 6
$137 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Everything was great except the staff at the bar. The first girl didn’t know how to use a bottle opener to open a beer. I asked the second girl to put in a grilled cheese right away so I can bring it up to my 1 year old baby. It took about an hour to get this grilled cheese and it came out with the ...
Reviewed on Mar 27, 2026

Howard Johnson by Wyndham Florence
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $68 total per night from Apr 26 to Apr 27
$68 total
Apr 26 - Apr 27
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Stay was good. Staff was great. A problem with the drain in the bathroom but they were very nice about it
Reviewed on Mar 26, 2026

SpringHill Suites by Marriott Florence
2670 Hospitality Blvd Florence SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $119 total per night from Mar 31 to Apr 1
$119 total
Mar 31 - Apr 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Second time staying here! Love it, bathroom needs a lit bit love but is okay!
Reviewed on Mar 27, 2026

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
2101 Florence Harllee Blvd Florence SC
Fully refundable
$131 nightly
The price is $147 total per night from Apr 12 to Apr 13
$147 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
The stay was great
Reviewed on Mar 10, 2026

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $97 total per night from Apr 26 to Apr 27
$97 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Room was very clean. Beds are on the firm side. Pool was closed even though the sign at desk stated it should be open. Breakfast was extremely minimal. Front desk agent was very rude and acted as if I was bothering her. Horrible customer service skills. This is a one and done stay.
Reviewed on Mar 28, 2026

Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95 Florence SC
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $69 total per night from Apr 7 to Apr 8
$69 total
Apr 7 - Apr 8
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...
Great
Reviewed on Mar 27, 2026

Microtel Inn & Suites by Wyndham Florence
1912 Enterprise Dr Florence SC
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $68 total per night from Mar 29 to Mar 30
$68 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Staff was exceptional, very friendly and helpful check in was quick and easy and plesant. Rooms were renovated and very clean and spacious. Beds were comfortable. Bathrooms were clean though the tub either needed to be scrubbed better or needs resurfaced because it looked a bit dingy. Shower head ...
Reviewed on Mar 28, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Pamplico with star-rating
Check Pamplico Hotels by Star Rating

3 Star Hotels
13 properties
Frequently asked questions
Recent Pamplico hotel reviews by fellow wanderers

Microtel Inn & Suites by Wyndham Florence
4 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Staff was exceptional, very friendly and helpful
check in was quick and easy and plesant. Rooms were renovated and very clean and spacious. Beds were comfortable. Bathrooms were clean though the tub either needed to be scrubbed better or needs resurfaced because it looked a bit dingy. Shower head needs to be replaced but water pressure was great and HOT. There is NO fan in the bathroom so it gets really hot in there. The only thing i was super disappointed in was breakfast. All the reviews said it was good but it was awful. there was was muffins, bread, yogurt and cereal...and there may have been apples but they were gone. If they would do a better breakfast selection with at least a waffle maker and some kind of hot food like wggs and sausage they would have a really nice hotel. It was a convenient and safe location to the interstate and well lit. Lots of food choces around as well. Overall a great budget hotel just needs a little tweaking. "
A verified traveler stayed at Microtel Inn & Suites by Wyndham Florence
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