Book Hotels in Pamplico, SC
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Top Pamplico hotels

Comfort Inn & Suites Florence Center Area
527 Woody Jones Blvd Florence SC
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $107 total per night from Feb 15 to Feb 16
$107 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Nice
Reviewed on Feb 10, 2026

Park Inn by Radisson Florence, SC
1729 Mandeville Road Florence SC
Fully refundable
$85 nightly
The price is $95 total per night from Feb 22 to Feb 23
$95 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Business travelers can take advantage of the business center. Enjoy ...
Very clean. The staff was so friendly and helpful. The breakfast was great!!! I’ll definitely be back
Reviewed on Feb 12, 2026

Hyatt Place Florence Downtown
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $112 total per night from Feb 23 to Feb 24
$112 total
Feb 23 - Feb 24
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Friendly staff
Reviewed on Feb 4, 2026

TownePlace Suites by Marriott Florence
2650 Hospitality Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $118 total per night from Feb 15 to Feb 16
$118 total
Feb 15 - Feb 16
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
yes the room was clean and staff was good
Reviewed on Feb 12, 2026

Residence Inn Marriott Florence
2660 Hospitality Blvd Florence SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $111 total per night from Feb 22 to Feb 23
$111 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free continental ...
The room was large and clean. New. The breakfast was great. I've stayed at Residence Inns a few times and have always had excellent experiences.
Reviewed on Feb 5, 2026

Howard Johnson by Wyndham Florence
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $75 total per night from Feb 15 to Feb 16
$75 total
Feb 15 - Feb 16
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Room was great and clean, staff friendly and helpful.
Reviewed on Feb 11, 2026

La Quinta Inn & Suites by Wyndham Florence
2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Feb 22 to Feb 23
$106 total
Feb 22 - Feb 23
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Great breakfast, friendly staff.
Reviewed on Feb 7, 2026

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $93 total per night from Mar 15 to Mar 16
$93 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Clean room. Newly remodeled bathroom
Reviewed on Feb 9, 2026

Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95 Florence SC
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $67 total per night from Feb 20 to Feb 21
$67 total
Feb 20 - Feb 21
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...
Comfortable and safe
Reviewed on Feb 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Pamplico with star-rating
Check Pamplico Hotels by Star Rating

3 Star Hotels
13 properties
Frequently asked questions
Recent Pamplico hotel reviews by fellow wanderers

Park Inn by Radisson Florence, SC
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Very clean. The staff was so friendly and helpful.
The breakfast was great!!! I’ll definitely be back "
A verified traveler stayed at Park Inn by Radisson Florence, SC
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- Flights to Marion
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- American Airlines Charlotte (CLT) to Florence (FLO) flights
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