Book Hotels in Pamplico, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Pamplico hotels

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Fully refundable
$89 nightly
The price is $100 total per night from Jun 21 to Jun 22
$100 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free ...
"This time they charged me twice as much for the pet fee because they multiplied by 2 dogs, but every time I have stayed here in very recent history it was one fee for both dogs (which only weigh 7 lbs each). I tried to get the staff person to check on my previouse stay bill and she would not confirm ..."

Reviewed on Jun 14, 2026

Opens in a new windowPark Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Fully refundable
$105 nightly
The price is $117 total per night from Jun 21 to Jun 22
$117 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
"Excellent service"

Reviewed on Jun 13, 2026

Opens in a new windowComfort Inn & Suites Florence Center Area
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $128 total per night from Jul 6 to Jul 7
$128 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"The AC made a funny noise and the receptionist didn’t come off friendly or helpful. More bothered than anything. Other than that it was a good stay. Would stay again maybe."

Reviewed on Jun 9, 2026

Opens in a new windowHyatt Place Florence Downtown
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $76 total per night from Jun 15 to Jun 16
$76 total
Jun 15 - Jun 16
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"The room was clean, quiet and comfortable and the staff was very helpful and very nice. And unlike some, the TV actually worked correctly. Will most likely stay there again on our way back through."

Reviewed on Jun 12, 2026

Opens in a new windowHoward Johnson by Wyndham Florence
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

2.5 out of 5
2101 Florence Harllee Blvd Florence SC
Fully refundable
$131 nightly
The price is $147 total per night from Jun 21 to Jun 22
$147 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"Very clean. Good breakfast buffet. Safe place to stay."

Reviewed on Jun 14, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $95 total per night from Jun 21 to Jun 22
$95 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Only stayed one night and got there late but it was a nice big clean room. The bed was comfortable."

Reviewed on Jun 14, 2026

Opens in a new windowSpark by Hilton Florence North I-95, SC
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $94 total per night from Jun 15 to Jun 16
$94 total
Jun 15 - Jun 16
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"The king size bed was very comfortable and the room was very clean. Enjoyed the pet area for my dog to relieve herself along with the availability of scoop and poop bags."

Reviewed on Jun 11, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham Florence
Super 8 by Wyndham Florence

Super 8 by Wyndham Florence

2 out of 5
1832 1/2 Lucas Street, I95 Exit 164 Florence SC
Fully refundable
$54 nightly
The price is $60 total per night from Jun 15 to Jun 16
$60 total
Jun 15 - Jun 16
Total with taxes and fees
A seasonal outdoor pool is featured at this motel, along with free self parking. Guests will appreciate free perks like on-the-go breakfast and WiFi in public ...
"Honesty review!! The room was real clean!! I would’ve preferred more towels and face cloths but that wasn’t a huge turn off!! The parking is extremely tight!! It didn’t get cool in the room until 1AM but it’s South Carolina the heat might be different!! For the price I most definitely would stay ..."

Reviewed on Jun 13, 2026

Opens in a new windowSuper 8 by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $99 total per night from Jun 17 to Jun 18
$99 total
Jun 17 - Jun 18
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Opens in a new windowQuality Inn & Suites Florence Civic Center
Don't see what you're looking for?
See all available properties in Pamplico
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Pamplico?
Family trips are where you make the best memories, but it's no secret that traveling with young ones can be daunting. These kid-friendly Pamplico hotels come with perks designed to keep travelers of all ages relaxed and happy: Your entourage will enjoy their time at Cheerful home with plenty of privacy and entertainment room.. A fireplace and free WiFi are just a couple of the things that help make this hotel a winner. The Inn at the Crossroads is another excellent choice. After an exciting day of exploring, return to your cozy room and amenities like complimentary breakfast and a pillowtop mattress.
Where can I find cheap hotels in Pamplico?
At Travelocity you'll find really nice hotels in Pamplico at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Pamplico rather than in Pamplico. We may find you even better rates, too.
How do I find the best Pamplico hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Pamplico then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Pamplico?
The cheapest hotel in Pamplico is $60. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Pamplico?
There are 166 hotels in Pamplico on Travelocity.
What are the best hotels in Pamplico?
Pamplico has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Pamplico for you!
When is the best time to visit Pamplico?
If you want the joy of a fun-filled trip in peak season, visit Pamplico during March, April and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and October.
When is the cheapest time to stay in Pamplico?
Based on historic data is usually the cheapest month to visit Pamplico. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Pamplico?
There are multiple hotels in Pamplico that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Pamplico. We have plenty of kid-friendly hotels in Pamplico to choose from on Travelocity!
Why book a hotel in Pamplico through Travelocity?
Because we have the top hotels in Pamplico! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Pamplico on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Pamplico hotel reviews by fellow wanderers

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

4 out of 5
Posted 1 hour ago
Travelocity Verified Review
"This time they charged me twice as much for the pet fee because they multiplied by 2 dogs, but every time I have stayed here in very recent history it was one fee for both dogs (which only weigh 7 lbs each). I tried to get the staff person to check on my previouse stay bill and she would not confirm ."
A verified traveler stayed at Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SC

Explore More Ways to Travel with Travelocity