Book Hotels in Pamplico, SC
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Top Pamplico hotels

Comfort Inn & Suites Florence Center Area
527 Woody Jones Blvd Florence SC
Fully refundable
$101 nightly
The price is $113 total per night from Dec 2 to Dec 3
$113 total
Dec 2 - Dec 3
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
"I was not impressed. The room is outdated. Smelt old. Two significant tears in the rug. The mattress was comfortable.👍 I didn’t find anything I’d consider eating for Breakfast. not even the coffee. The staff was friendly"
Reviewed on Nov 10, 2026

Hampton Inn & Suites Florence Center
3000 W Radio Dr Florence SC
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $128 total per night from Nov 22 to Nov 23
$128 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"La cama muy cómoda, los espacios bien utilizados, excelente ducha y productos de baño. El desayuno increíble"
Reviewed on Nov 8, 2026

Howard Johnson by Wyndham Florence
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $72 total per night from Nov 12 to Nov 13
$72 total
Nov 12 - Nov 13
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
"Nice location off of interstate 95. Excellent customer service and clean room."
Reviewed on Nov 11, 2026

Spark by Hilton Florence North I-95, SC
1739 Mandeville Rd Florence SC
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $114 total per night from Nov 17 to Nov 18
$114 total
Nov 17 - Nov 18
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"M"
Reviewed on Nov 11, 2026

SpringHill Suites by Marriott Florence
2670 Hospitality Blvd Florence SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $123 total per night from Nov 15 to Nov 16
$123 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free continental ...
"The hotel pool amd rooms were nice, and there was a big variety for breakfast. Our toilet didn't work well, and the tub slanted inward to the middle but otherwise enjoyable."
Reviewed on Nov 3, 2026

Park Inn by Radisson Florence, SC
1729 Mandeville Road Florence SC
Fully refundable
$90 nightly
The price is $101 total per night from Nov 15 to Nov 16
$101 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free ...

Hyatt Place Florence Downtown
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $130 total per night from Nov 15 to Nov 16
$130 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $74 total per night from Dec 6 to Dec 7
$74 total
Dec 6 - Dec 7
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...

The Inn at the Crossroads
128 West Main Street Lake City SC
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $142 total per night from Dec 10 to Dec 11
$142 total
Dec 10 - Dec 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Pamplico with star-rating
Check Pamplico Hotels by Star Rating

3 Star Hotels
28 properties
Frequently asked questions
Recent Pamplico hotel reviews by fellow wanderers

Howard Johnson by Wyndham Florence
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Nice location off of interstate 95. Excellent customer service and clean room."
A verified traveler stayed at Howard Johnson by Wyndham Florence
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