Explore top 2026 4 Star Hotels in Otay Mesa

Name: Sheraton Mission Valley San Diego Hotel
Price range: $155 total
Rating: 8.6

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Top Otay Mesa 4 Star hotels

Hotel del Coronado, Curio Collection by Hilton

1500 Orange Ave Coronado CA

Fully refundableReserve now, pay when you stay

$551 nightly

$611 total

Feb 28 - Mar 1

Total with taxes and fees

A private beach, 6 restaurants, and an outdoor pool are all featured at this Victorian resort. Relax with sun loungers and beach umbrellas, and cool off with ...

8.6/10 Excellent! (1,009 reviews)

Staff is very friendly and helpful. It’s a gorgeous hotel.

Reviewed on Feb 21, 2026

Hard Rock Hotel San Diego

207 5th Ave San Diego CA

Fully refundableReserve now, pay when you stay

$254 nightly

$294 total

Feb 23 - Feb 24

Total with taxes and fees

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...

9/10 Wonderful! (3,340 reviews)

Excellent service

Reviewed on Feb 21, 2026

DoubleTree by Hilton Hotel San Diego - Mission Valley

7450 Hazard Center Dr San Diego CA

Fully refundableReserve now, pay when you stay

$144 nightly

$166 total

Mar 1 - Mar 2

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 20 conference rooms, free WiFi in public areas, ...

8.4/10 Very Good! (1,540 reviews)

Staff was great, very friendly! Loved the location and the room.

Reviewed on Feb 17, 2026

Courtyard by Marriott San Diego Downtown Little Italy

1646 Front St San Diego CA

Fully refundableReserve now, pay when you stay

$184 nightly

$213 total

Mar 12 - Mar 13

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and free internet ...

9/10 Wonderful! (385 reviews)

Really nice place I will totally recommend it !!

Reviewed on Feb 21, 2026

Hilton San Diego Mission Valley

901 Camino Del Rio S San Diego CA

Fully refundableReserve now, pay when you stay

$122 nightly

$141 total

Mar 1 - Mar 2

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

8/10 Very Good! (2,331 reviews)

Room spotless and staff was friendly.

Reviewed on Feb 19, 2026

Legacy Resort Hotel & Spa

875 Hotel Circle South San Diego CA

Fully refundableReserve now, pay when you stay

$180 nightly

$207 total

Mar 18 - Mar 19

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.2/10 Wonderful! (2,958 reviews)

Great Place To Stay

Reviewed on Feb 22, 2026

Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA

Fully refundableReserve now, pay when you stay

$184 nightly

$213 total

Mar 1 - Mar 2

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.4/10 Very Good! (6,052 reviews)

Great location but hotel most certainly needs updating. Beds were good

Reviewed on Feb 21, 2026

Embassy Suites by Hilton San Diego Bay Downtown

601 Pacific Hwy San Diego CA

Fully refundableReserve now, pay when you stay

$203 nightly

$235 total

Mar 1 - Mar 2

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, express check-in, and valet ...

9/10 Wonderful! (1,645 reviews)

Husband and I decided to visit San Diego last minute and after researching the downtown area decided the location of ES fit us perfectly. Short walk from the 992 bus stop to and from the airport. We booked through Expedia and selected a King Corner Suite. We had a wonderful view of the Harbor and ...

Reviewed on Feb 21, 2026

Lafayette Hotel & Club

2223 El Cajon Blvd San Diego CA

Fully refundableReserve now, pay when you stay

$229 nightly

$263 total

Feb 23 - Feb 24

Total with taxes and fees

This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...

9.4/10 Exceptional! (1,486 reviews)

A totally unique and wonderful experience!

Reviewed on Feb 22, 2026

Sheraton Mission Valley San Diego Hotel

1433 Camino Del Rio S San Diego CA

Fully refundableReserve now, pay when you stay

$135 nightly

$155 total

Feb 26 - Feb 27

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

8.6/10 Excellent! (1,731 reviews)

Staff was very curteous. Room could have been cleaner ie bugs in light in bathroom, thick dust on ledges of bed headboard. stains on dust ruffles. Empty body wash in shower. Would have expected better from Sheraton.

Reviewed on Feb 22, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.