Explore the best 2025 4 Star Hotels Hotels in Key West Historic District
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Top Key West Historic District 4 Star hotels

Southernmost Beach Resort and Guesthouses
1319 Duval Street, Key West, FL
Free Cancellation
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling for business? Take advantage of the 24-hour business center, laundry service, and conference space.

La Concha Key West, Autograph Collection
430 Duval St, Key West, FL
Free Cancellation
Reserve now, pay when you stay
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and valet parking. There's a poolside bar on site, and a 24-hour front desk and concierge services are also provided.
Pool
Pet friendly

Hyatt Centric Key West Resort and Spa
601 Front St, Key West, FL
Free Cancellation
Reserve now, pay when you stay
This eco-certified resort features a full-service spa, a marina, and a restaurant. Enjoy the outdoor pool and perks like free WiFi. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Pier House Resort & Spa
1 Duval St, Key West, FL
Free Cancellation
Reserve now, pay when you stay
This smoke-free resort features a private beach, a full-service spa, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, business center, and express check-in.

The Reach Key West, Curio Collection by Hilton
1435 Simonton Street, Key West, FL
Free Cancellation
Reserve now, pay when you stay
This resort features a private beach, a full-service spa, and a restaurant. Traveling on business? Take advantage of the express check-out, laundry service, and valet parking. Enjoy the outdoor pool and unwind at the bar/lounge and poolside bar.

Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street, Key West, FL
Free Cancellation
Reserve now, pay when you stay
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off with a drink at the beachside bar. Enjoy the gym and perks like free WiFi.

Opal Key Resort & Marina, Key West
245 Front Street, Key West, FL
Free Cancellation
Reserve now, pay when you stay
A marina, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the outdoor pool and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub

The Marker Key West Harbor Resort
200 William Street, Key West, FL
Free Cancellation
Reserve now, pay when you stay
This eco-certified hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. There's a bar/lounge on site, and a 24-hour front desk and concierge services are also provided.

Winslow's Bungalows - Key West Historic Inns
725 Truman Avenue, Key West, FL
Free Cancellation
Reserve now, pay when you stay
This smoke-free hotel features 3 outdoor pools, a bar/lounge, and a poolside bar. Guests will appreciate free perks like continental breakfast and WiFi in public areas. Self parking, a garden, and luggage storage are also offered.
Pool
Breakfast included

The Mansion on the Sea - Southernmost House in the USA
1400 Duval Street, Key West, FL
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Unwind with a drink at the poolside bar and enjoy perks like free continental breakfast and free WiFi. Self parking, a terrace, and a garden are also offered.
Pool
Breakfast included

Bishop Hotel Key West
822 Fleming St, Key West, FL
This guesthouse's 2 outdoor pools and hot tub are among the featured amenities. Unwind with a drink at the poolside bar and enjoy perks like free continental breakfast and free WiFi. There's luggage storage and multilingual staff can provide around-the-clock assistance.

Santa Maria Suites
1401 Simonton St, Key West, FL
This smoke-free resort features 2 outdoor pools, a gym, and a restaurant. Relax with a drink at the bar/lounge and enjoy perks like free WiFi. There's a poolside bar on site, and a 24-hour front desk and laundry facilities are also provided.
Pool
Free WiFi
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Key West Historic District hotels essential information
Accommodation | 1,770 hotels |
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Lowest Price | |
Highest Price | |
Popular hotels | Southernmost Beach Resort and Guesthouses, La Concha Key West, Autograph Collection, Hyatt Centric Key West Resort and Spa, Pier House Resort & Spa, The Reach Key West, Curio Collection by Hilton, Casa Marina Key West, Curio Collection by Hilton, Opal Key Resort & Marina, Key West, The Marker Key West Harbor Resort, Winslow's Bungalows - Key West Historic Inns, The Mansion on the Sea - Southernmost House in the USA, Bishop Hotel Key West, Santa Maria Suites |
Recent Key West Historic District hotel reviews by fellow wanderers

Duval House
5 out of 5
Posted 10 hours ago
Travelocity Verified Review
"Gorgeous property . The room is beautiful and breakfast was amazing as well as the gardens"
A verified traveler from Surrey stayed at Duval House
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