Explore 64 Luxury Hotels in Key West

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Best Luxury Hotels in Key West

H2O Suites - Adults Only

H2O Suites - Adults Only

1212 Simonton Street Key West FL
$709 nightly
The price is $798 total per night from Apr 5 to Apr 6
$798 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (588 reviews)
Very nice, very clean with great staff and convenient parking. The "private" pools are all in a courtyard so you can make awkward eye contact with the

Reviewed on Mar 3, 2026

Opens in a new windowH2O Suites - Adults Only
Santa Maria Suites

Santa Maria Suites

1401 Simonton St Key West FL
$682 nightly
The price is $768 total per night from Apr 5 to Apr 6
$768 total
Apr 5 - Apr 6
Total with taxes and fees
This smoke-free resort features 2 outdoor pools, a gym, and a restaurant. Relax with a drink at the bar/lounge and enjoy perks like free WiFi. There's a poolside ...
9.6/10 Exceptional! (1,001 reviews)
The resort had a very comfortable heated pool with nice grounds, chairs and tables. A staff member was always present offering free water and icee type drinks. Happy hour from 4 to 530 was incredibly generous and good. Rooms were very spacious, clean and up to date. Our stay was enjoyable and we ...

Reviewed on Mar 3, 2026

Opens in a new windowSanta Maria Suites
Southernmost House

Southernmost House

1400 Duval Street Key West FL
$592 nightly
The price is $666 total per night from Mar 23 to Mar 24
$666 total
Mar 23 - Mar 24
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Guests will appreciate free perks like continental breakfast and WiFi in public areas. Self ...
9.4/10 Exceptional! (1,007 reviews)
Staff went beyond what was expected to assist. Great location, and continental breakfast. Rooms were good size.

Reviewed on Mar 7, 2026

Opens in a new windowSouthernmost House
The Marker Key West Harbor Resort

The Marker Key West Harbor Resort

200 William Street Key West FL
Fully refundableReserve now, pay when you stay
$613 nightly
The price is $690 total per night from Apr 5 to Apr 6
$690 total
Apr 5 - Apr 6
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9.2/10 Wonderful! (1,011 reviews)
Great location!! Afternoon music by the pool was excellent! Very walkable to great breakfast and dinner options!

Reviewed on Mar 7, 2026

Opens in a new windowThe Marker Key West Harbor Resort
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL
Fully refundable
$596 nightly
The price is $671 total per night from Mar 24 to Mar 25
$671 total
Mar 24 - Mar 25
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling ...
8.8/10 Excellent! (3,138 reviews)
The room is nice and clean, we don't really have any view. I would book ocean view next time.

Reviewed on Mar 9, 2026

Opens in a new windowSouthernmost Beach Resort and Guesthouses
Fairfield by Marriott Inn & Suites Key West at The Keys Collection

Fairfield by Marriott Inn & Suites Key West at The Keys Collection

3852 North Roosevelt Boulevard Key West FL
Fully refundableReserve now, pay when you stay
$339 nightly
The price is $381 total per night from Mar 22 to Mar 23
$381 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
8.6/10 Excellent! (1,013 reviews)
Hands down, one of the best hotel stays I’ve had in awhile. Continental breakfast was delicious and well stocked. Rooms are large and comfortable. Shuttle to downtown was extra convenient. And I really enjoyed the pool area to spend the afternoon reading a book.

Reviewed on Mar 10, 2026

Opens in a new windowFairfield by Marriott Inn & Suites Key West at The Keys Collection
Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton

1500 Reynolds Street Key West FL
Fully refundableReserve now, pay when you stay
$618 nightly
The price is $695 total per night from Mar 24 to Mar 25
$695 total
Mar 24 - Mar 25
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
8.4/10 Very Good! (573 reviews)
Great stay

Reviewed on Mar 9, 2026

Opens in a new windowCasa Marina Key West, Curio Collection by Hilton
Seashell Motel

Seashell Motel

718 South Street Key West FL
Fully refundableReserve now, pay when you stay
$318 nightly
The price is $358 total per night from Apr 1 to Apr 2
$358 total
Apr 1 - Apr 2
Total with taxes and fees
This hostel doesn't skimp on freebies - guests receive free WiFi and free self parking. A garden, a picnic area, and luggage storage are also on offer.
8/10 Very Good! (1,007 reviews)
Clean room and nice bathroom. Easy walk to lots of restaurants and Duval. Would stay again!

Reviewed on Mar 6, 2026

Opens in a new windowSeashell Motel
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More 4 star hotels in Key West

Key West Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Key West luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Key West to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Key West will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Key West, and plan your next opulent escape.


Key West hotels essential information

Accommodation
2,707 hotels
Lowest Price
$358
Highest Price
$798
Popular hotels
The Marker Key West Harbor Resort, Casa Marina Key West, Curio Collection by Hilton, Southernmost Beach Resort and Guesthouses, H2O Suites - Adults Only, Seashell Motel, Southernmost House, Fairfield by Marriott Inn & Suites Key West at The Keys Collection, Santa Maria Suites

Popular Luxury Stays in Key West

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