Explore 64 Luxury Hotels in Key West

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Best Luxury Hotels in Key West

H2O Suites - Adults Only

H2O Suites - Adults Only

1212 Simonton Street Key West FL
$389 nightly
The price is $438 total per night from Jun 10 to Jun 11
$438 total
Jun 10 - Jun 11
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (611 reviews)
"Lo máximo lo recomiendo 100% todo super rentas los que ves muy muy bueno el proximo año sin dudas lo vuelvo a visitar"

Reviewed on May 29, 2026

Opens in a new windowH2O Suites - Adults Only
Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive

1400 Duval Street Key West FL
$304 nightly
The price is $342 total per night from Jun 21 to Jun 22
$342 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Guests will appreciate free perks like cooked-to-order breakfast and WiFi in public areas. ...
9.4/10 Exceptional! (1,001 reviews)
"This is a wonderful old mansion. I love that they did NOT modernize it to the point it’s lost its charm and character. The staff were amazing. The room was nice, clean and cool with a nice view. I would highly recommend staying here. The only negatives experienced is the noise level. Be prepared ..."

Reviewed on May 30, 2026

Opens in a new windowSouthernmost House - Adult Exclusive
The Marker Key West Harbor Resort

The Marker Key West Harbor Resort

200 William Street Key West FL
Fully refundableReserve now, pay when you stay
$282 nightly
The price is $317 total per night from Jun 15 to Jun 16
$317 total
Jun 15 - Jun 16
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9.2/10 Wonderful! (1,008 reviews)
"Our room was right across from a room used for housekeeping items. It is often very loud in the morning and at night time. The last night we were there, not sure if it was guests or employees but people were talking very loud in the hallway and in the rooms. Lasted until almost 11:30pm and again ..."

Reviewed on Jun 8, 2026

Opens in a new windowThe Marker Key West Harbor Resort
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue Key West FL
Fully refundableReserve now, pay when you stay
$247 nightly
The price is $277 total per night from Jun 29 to Jun 30
$277 total
Jun 29 - Jun 30
Total with taxes and fees
A marina, 6 outdoor pools, and a 24-hour gym are all featured at this smoke-free hotel. Business travelers can take advantage of the free WiFi in public areas. ...
9/10 Wonderful! (1,874 reviews)
"The Oceans Edge is an incredible resort. I was a little wary of staying on Stock Island instead of downtown Key West itself, however when I saw the tropical gates of the hotel all of my concerns were blown away. Everything about this hotel is stunning, from the luscious tropical grounds to the beautifully ..."

Reviewed on Jun 7, 2026

Opens in a new windowOceans Edge Key West Resort, Hotel & Marina
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

1319 Duval Street Key West FL
Fully refundableReserve now, pay when you stay
$261 nightly
The price is $294 total per night from Jun 29 to Jun 30
$294 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling ...
8.8/10 Excellent! (3,375 reviews)
"Espectacular"

Reviewed on Jun 8, 2026

Opens in a new windowSouthernmost Beach Resort and Guesthouses
Fairfield by Marriott Inn & Suites Key West at The Keys Collection

Fairfield by Marriott Inn & Suites Key West at The Keys Collection

3852 North Roosevelt Boulevard Key West FL
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $176 total per night from Jun 22 to Jun 23
$176 total
Jun 22 - Jun 23
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
8.6/10 Excellent! (1,017 reviews)
"The staff at the hotel were incredibly friendly and helpful from start to finish. We loved the pool, which was kept at the perfect, warm temperature. The complimentary shuttle to the old district was a huge plus, and having beach essentials like umbrellas, chairs, and coolers provided made our outings ..."

Reviewed on Jun 9, 2026

Opens in a new windowFairfield by Marriott Inn & Suites Key West at The Keys Collection
Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton

1500 Reynolds Street Key West FL
Fully refundableReserve now, pay when you stay
$285 nightly
The price is $320 total per night from Jun 24 to Jun 25
$320 total
Jun 24 - Jun 25
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
8.4/10 Very Good! (696 reviews)
"We arrived to the property, the room we originally booked which was the ocean front room was not available. They placed us in a different room that was supposed to be complimentary to the room we booked for the first night and it was not. We were told the oceanfront room would be ready the next day ..."

Reviewed on Jun 8, 2026

Opens in a new windowCasa Marina Key West, Curio Collection by Hilton
Seashell Motel

Seashell Motel

718 South Street Key West FL
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $135 total per night from Jun 10 to Jun 11
$135 total
Jun 10 - Jun 11
Total with taxes and fees
This hostel doesn't skimp on freebies - guests receive free WiFi and free self parking. A picnic area, luggage storage, and concierge services are also on ...
8/10 Very Good! (1,010 reviews)
"Loved the close proximity to walk to the popular Duvall street for shopping and dining. The bathroom was huge!! Upgraded bathroom fixtures and tile. Great water pressure. Adjustable temperature A/C unit which was cold that I chose to turn up. Comfortable plush mattress, though the bed squeaked a ..."

Reviewed on Jun 8, 2026

Opens in a new windowSeashell Motel
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More 4 star hotels in Key West

Key West Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Key West luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Key West to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Key West will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Key West, and plan your next opulent escape.


Key West hotels essential information

Accommodation
2,637 hotels
Lowest Price
$135
Highest Price
$438
Popular hotels
Oceans Edge Key West Resort, Hotel & Marina, The Marker Key West Harbor Resort, Casa Marina Key West, Curio Collection by Hilton, Southernmost Beach Resort and Guesthouses, H2O Suites - Adults Only, Seashell Motel, Southernmost House - Adult Exclusive, Fairfield by Marriott Inn & Suites Key West at The Keys Collection

Popular Luxury Stays in Key West

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