Book Hotels in Effingham, SC
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Top Effingham hotels

The Inn at the Crossroads
128 West Main Street, Lake City, SC
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $145 total per night from Oct 15 to Oct 16
$145 total
Oct 15 - Oct 16
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Clean,easy parking,Comfy beds and friendly staff.Def recommend 10/10"
Reviewed on Sep 28, 2025

Comfort Inn & Suites
527 Woody Jones Blvd, Florence, SC
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $107 total per night from Oct 5 to Oct 6
$107 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
"The staff at check in was very friendly and cheerful. Property is convenient to restaurants and is clean and quiet. Love the gnome decorations!"
Reviewed on Sep 24, 2025

Park Inn by Radisson Florence, SC
1729 Mandeville Road, Florence, SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Oct 5 to Oct 6
$106 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Business travelers can take advantage of the business center. Enjoy ...
"The carpets in the hallway were dirty and also were frayed in our room. There was a bit of trash the vacuum must have missed from the last occupants."
Reviewed on Sep 29, 2025

Hyatt Place Florence Downtown
100 East Evans Street Florence, Florence, SC
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $116 total per night from Oct 13 to Oct 14
$116 total
Oct 13 - Oct 14
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Stayed for 2 nights with my son for a tournament. Safe, clean, excellent location at the end of the street downtown so it was quiet at night. Yummy breakfast every morning. Convenient parking in lot across the street. Only qualm I had was our room wasn’t cleaned Saturday and when I inquired, I was ..."
Reviewed on Sep 26, 2025

TownePlace Suites by Marriott Florence
2650 Hospitality Boulevard, Florence, SC
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $116 total per night from Oct 5 to Oct 6
$116 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"Staff very friendly, welcoming and helpful. Room was excellent. Bed comfortable. Perfect location."
Reviewed on Sep 25, 2025

Howard Johnson by Wyndham Florence
2038 W Lucas Street, I-95 Exit 164, Florence, SC
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $73 total per night from Oct 5 to Oct 6
$73 total
Oct 5 - Oct 6
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Very clean and comfortable"
Reviewed on Sep 30, 2025

La Quinta Inn & Suites by Wyndham Florence
2123 W Lucas St, Florence, SC
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $116 total per night from Oct 5 to Oct 6
$116 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"Great location"
Reviewed on Sep 24, 2025

Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $71 total per night from Oct 17 to Oct 18
$71 total
Oct 17 - Oct 18
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...
"I see some small bugs in the bathroom and the mirror frame is very dirty."
Reviewed on Sep 22, 2025

Microtel Inn & Suites by Wyndham Florence
1912 Enterprise Dr, Florence, SC
Fully refundableReserve now, pay when you stay
$54 nightly
The price is $61 total per night from Oct 5 to Oct 6
$61 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"The room was clean and comfortable. The breakfast was okay but had few options. Only 1 kind of mini muffins and limited cereal. My biggest issue is that they charged me for the room 2 times after I paid through Expedia. When I tried to explain to the manager, he blew me off, insisting he had refunded ..."
Reviewed on Sep 26, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Effingham hotel reviews by fellow wanderers

Howard Johnson by Wyndham Florence
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Very clean and comfortable "
A verified traveler stayed at Howard Johnson by Wyndham Florence
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