Explore the best 2025 4 Star Hotels Hotels in Otay Mesa
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Top Otay Mesa 4 Star hotels

Manchester Grand Hyatt San Diego
1 Market Pl, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$222 nightly
The price is $257 total per night
$257 total
Jul 20 - Jul 21
Total includes taxes and fees
This eco-certified hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the hot tub and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$169 nightly
The price is $195 total per night
$195 total
Jul 27 - Jul 28
Total includes taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, express check-out, and free airport shuttle. There's a bar/lounge on site, and concierge services and free newspapers are also provided.
Pool
Free airport shuttle

Loews Coronado Bay Resort
4000 Coronado Bay Rd, Coronado, CA
$300 nightly
The price is $334 total per night
$334 total
Jul 30 - Jul 31
Total includes taxes and fees
A full-service spa, a marina, and 3 outdoor pools are all featured at this hotel. Take the free beach shuttle and relax with sun loungers and beach umbrellas. There's fun for all ages with a children's pool and a playground, and families will appreciate the onsite laundry facilities.
Pool
Hot Tub

Marriott Marquis San Diego Marina
333 W Harbor Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$259 nightly
The price is $300 total per night
$300 total
Aug 17 - Aug 18
Total includes taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 5 restaurants. Families will appreciate the children's pool and onsite laundry facilities. Enjoy the 2 outdoor pools and perks like free WiFi.
Pool
Hot Tub

The Little Italy Hotel Downtown San Diego
1646 Front St, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$143 nightly
The price is $166 total per night
$166 total
Aug 6 - Aug 7
Total includes taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Self parking is offered and multilingual staff can provide around-the-clock assistance.
Pet friendly
Free WiFi

Sheraton San Diego Resort
1380 Harbor Island Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$205 nightly
The price is $236 total per night
$236 total
Aug 7 - Aug 8
Total includes taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. Enjoy the 2 hot tubs, and relax with drinks at the bar/lounge and poolside bar.
Pool
Hot Tub

Lafayette Hotel & Club
2223 El Cajon Blvd, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$244 nightly
The price is $280 total per night
$280 total
Jul 21 - Jul 22
Total includes taxes and fees
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the outdoor pool and conveniences like a 24-hour front desk and concierge services.
Pool
Pet friendly

Palihotel San Diego Gaslamp Quarter
830 Sixth Avenue, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$133 nightly
The price is $154 total per night
$154 total
Aug 19 - Aug 20
Total includes taxes and fees
This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and dry cleaning are also offered.
Pet friendly
Free WiFi

Hard Rock Hotel San Diego
207 5th Ave, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$255 nightly
The price is $295 total per night
$295 total
Aug 13 - Aug 14
Total includes taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free WiFi. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.
Pool
Free WiFi

DoubleTree by Hilton Hotel San Diego - Mission Valley
7450 Hazard Center Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$152 nightly
The price is $175 total per night
$175 total
Aug 3 - Aug 4
Total includes taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 20 conference rooms, free WiFi in public areas, and express check-out. There's an indoor pool on site, and laundry facilities and wedding services are also offered.
Pool
Pet friendly

Sheraton Mission Valley San Diego Hotel
1433 Camino Del Rio S, San Diego, CA
$122 nightly
The price is $140 total per night
$140 total
Jul 21 - Jul 22
Total includes taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. There's a hot tub on site, and a 24-hour front desk and a terrace are also provided.
Pool
Hot Tub

Hilton San Diego Mission Valley
901 Camino Del Rio S, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$131 nightly
The price is $150 total per night
$150 total
Jul 22 - Jul 23
Total includes taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. There's a 24-hour gym on site, and laundry facilities and concierge services are also offered.
Pool
Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa hotels essential information
Accommodation | 4,601 hotels |
---|---|
Lowest Price | $140 |
Highest Price | $334 |
Popular hotels | Manchester Grand Hyatt San Diego, Wyndham San Diego Bayside, Loews Coronado Bay Resort, Marriott Marquis San Diego Marina, The Little Italy Hotel Downtown San Diego, Sheraton San Diego Resort, Lafayette Hotel & Club, Palihotel San Diego Gaslamp Quarter, Hard Rock Hotel San Diego, DoubleTree by Hilton Hotel San Diego - Mission Valley, Sheraton Mission Valley San Diego Hotel, Hilton San Diego Mission Valley |
Recent Otay Mesa hotel reviews by fellow wanderers

Handlery Hotel
5 out of 5
Posted 11 hours ago
Travelocity Verified Review
"Great relaxing night, awesome restaurants, and bar and close to the beaches."
A verified traveler stayed at Handlery Hotel
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