Explore top 2026 4 Star Hotels in Otay Mesa

Name: Omni San Diego Hotel at the Ballpark
Price range: $271 total
Rating: 9.2

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Top Otay Mesa 4 Star hotels

Hard Rock Hotel San Diego

207 5th Ave San Diego CA

Fully refundableReserve now, pay when you stay

$254 nightly

$294 total

Mar 12 - Mar 13

Total with taxes and fees

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...

9/10 Wonderful! (3,397 reviews)

This hotel is beautiful. There’s so many beautiful restaurants all around you. Their rooms are very small, but extremely clean. For the price this room definitely wasn’t worth it.

Reviewed on Mar 9, 2026

Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA

Fully refundableReserve now, pay when you stay

$245 nightly

$281 total

Apr 5 - Apr 6

Total with taxes and fees

This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...

8.8/10 Excellent! (2,451 reviews)

Property was old and not well kept. We had to transfer rooms. Bathrooms were extremely small and difficult to maneuver. This is an old property and was very disappointing and underwhelming. Close to beach access was the only good thing.

Reviewed on Mar 9, 2026

Embassy Suites by Hilton San Diego Bay Downtown

601 Pacific Hwy San Diego CA

Fully refundableReserve now, pay when you stay

$203 nightly

$236 total

Apr 2 - Apr 3

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, express check-in, and valet ...

9/10 Wonderful! (1,665 reviews)

Clean

Reviewed on Mar 8, 2026

San Diego Mission Bay Resort

1775 E Mission Bay Dr San Diego CA

Fully refundableReserve now, pay when you stay

$305 nightly

$351 total

Mar 15 - Mar 16

Total with taxes and fees

A full-service spa, 2 restaurants, and 5 outdoor tennis courts are all featured at this Mediterranean resort. There's fun for all ages with a children's pool ...

8.4/10 Very Good! (1,365 reviews)

The resort is very nice and in a great location. My biggest complaint is the FREEZING pool and TINY hot tubs. No one wants to be in the pool because it’s too cold, and the hot tubs are over crowded. For such a high resort fee and high parking cost I would expect the pool to be heated. The pool service ...

Reviewed on Mar 8, 2026

Hyatt Regency Mission Bay Spa and Marina

1441 Quivira Rd San Diego CA

Fully refundableReserve now, pay when you stay

$233 nightly

$268 total

Apr 5 - Apr 6

Total with taxes and fees

This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.4/10 Very Good! (1,612 reviews)

The staff were super nice. My complaint is the rooms are a little outdated and you can see the wear and tear. We loved the location and my kids loved the pool and slides, although we wished the slides either stayed open later or opened earlier since check in and check out don’t really coincide with ...

Reviewed on Mar 8, 2026

Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA

Fully refundableReserve now, pay when you stay

$182 nightly

$211 total

Mar 11 - Mar 12

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.4/10 Very Good! (6,091 reviews)

Great pre cruise stay. Could walk to many nearby restaurants. Cruise terminal across the street. Friendly staff

Reviewed on Mar 9, 2026

San Diego Marriott Gaslamp Quarter

660 K St San Diego CA

Fully refundableReserve now, pay when you stay

$161 nightly

$186 total

Apr 2 - Apr 3

Total with taxes and fees

A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, express ...

8.8/10 Excellent! (1,674 reviews)

Great stay

Reviewed on Mar 4, 2026

Lafayette Hotel & Club

2223 El Cajon Blvd San Diego CA

Fully refundableReserve now, pay when you stay

$229 nightly

$263 total

Mar 10 - Mar 11

Total with taxes and fees

This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...

9.2/10 Wonderful! (1,512 reviews)

Love this place. Everything was there! A bar for drinking, a pool for lounging, a diner for eating, and a restaurant for more eating. The place was one of a kind, and we plan on coming back.

Reviewed on Mar 9, 2026

Hotel Indigo San Diego-Gaslamp Quarter by IHG

509 9th Ave San Diego CA

Fully refundable

$192 nightly

$223 total

Apr 5 - Apr 6

Total with taxes and fees

This smoke-free hotel's 2 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.8/10 Excellent! (1,017 reviews)

Hidden amenity fee for terrible amenities. Amenities include bottled water and $15 per night. They say you can use the $15 for breakfast but if you stay for only 1 night you cannot use it the morning you check out. Every thing felt like a scam. Not to mention we had to ask for a new room because ...

Reviewed on Mar 9, 2026

Omni San Diego Hotel at the Ballpark

675 L St San Diego CA

Fully refundableReserve now, pay when you stay

$234 nightly

$271 total

Apr 3 - Apr 4

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (2,083 reviews)

Excellent service, beautiful clean room and great location. We will definitely be back

Reviewed on Mar 4, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.