Explore top 2026 4 Star Hotels in Otay Mesa
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Top Otay Mesa 4 Star hotels

Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $274 total per night from May 25 to May 26
$274 total
May 25 - May 26
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (2,845 reviews)
The Manchester Hyatt always delivers as expected. They have valet and bellhop which is important to me traveling with a special needs child and I need the convenience of having some help moving all of the luggage up to the room and parking the car for us. The room was well appointed and clean. They ...
Reviewed on Apr 25, 2026

Loews Coronado Bay Resort
4000 Coronado Bay Rd Coronado CA
Fully refundableReserve now, pay when you stay
$238 nightly
The price is $265 total per night from May 25 to May 26
$265 total
May 25 - May 26
Total with taxes and fees
A full-service spa, a marina, and 3 outdoor pools are all featured at this hotel. Take the free beach shuttle and relax with sun loungers and beach umbrellas. ...
8.8/10 Excellent! (1,094 reviews)
Great bar staff.
Reviewed on Apr 25, 2026

Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$262 nightly
The price is $303 total per night from Apr 29 to Apr 30
$303 total
Apr 29 - Apr 30
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
9/10 Wonderful! (3,578 reviews)
Room was excellent, clean and beds and pillows were very comfortable!
Reviewed on Apr 25, 2026

Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $194 total per night from May 25 to May 26
$194 total
May 25 - May 26
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
8.4/10 Very Good! (3,485 reviews)
Overall amazing
Reviewed on Apr 22, 2026

Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $211 total per night from Apr 28 to Apr 29
$211 total
Apr 28 - Apr 29
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
8.4/10 Very Good! (6,121 reviews)
Breakfast was very good!
Reviewed on Apr 25, 2026

Hyatt Regency Mission Bay Spa and Marina
1441 Quivira Rd San Diego CA
Fully refundableReserve now, pay when you stay
$215 nightly
The price is $247 total per night from Apr 30 to May 1
$247 total
Apr 30 - May 1
Total with taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
8.4/10 Very Good! (1,620 reviews)
Every day went there was very polite. It’s great for kids. The pool is open till 10. The slides do close early though at 5 PM I think.
Reviewed on Apr 25, 2026

Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$264 nightly
The price is $303 total per night from May 10 to May 11
$303 total
May 10 - May 11
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
8.8/10 Excellent! (2,548 reviews)
The resort is lovely and has a very tropical lush feel we were stay vacationing 30 minutes from home and it really felt like we’d flown to Hawaii or somewhere in the South Pacific. The accommodation was great for a family of four, with a nice bungalow, large bedroom space and cute bathroom and we ...
Reviewed on Apr 25, 2026

Lafayette Hotel & Club
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $286 total per night from Apr 27 to Apr 28
$286 total
Apr 27 - Apr 28
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 3 bars/lounges, and a poolside bar. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
9.2/10 Wonderful! (1,614 reviews)
We had a fantastic time. Planned on going out in north park but just ended up enjoying the hotel!
Reviewed on Apr 25, 2026

Marriott Marquis San Diego Marina
333 W Harbor Dr San Diego CA
Fully refundableReserve now, pay when you stay
$280 nightly
The price is $324 total per night from May 2 to May 3
$324 total
May 2 - May 3
Total with taxes and fees
A marina, 5 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Bring the family and enjoy the children's pool and kid-friendly dining. ...
9.2/10 Wonderful! (2,089 reviews)
Good place
Reviewed on Apr 25, 2026

Omni San Diego Hotel at the Ballpark
675 L St San Diego CA
$208 nightly
The price is $241 total per night from May 25 to May 26
$241 total
May 25 - May 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9.2/10 Wonderful! (2,141 reviews)
Great place
Reviewed on Apr 25, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Otay Mesa hotel reviews by fellow wanderers

Wyndham San Diego Bayside
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Breakfast was very good!"
A verified traveler stayed at Wyndham San Diego Bayside
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