Explore top 2026 4 Star Hotels in Otay Mesa

Name: San Diego Marriott Mission Valley
Price range: $194 total

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Top Otay Mesa 4 Star hotels

Manchester Grand Hyatt San Diego

1 Market Pl San Diego CA

Fully refundableReserve now, pay when you stay

$238 nightly

$276 total

Sep 6 - Sep 7

Total with taxes and fees

This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...

9/10 Wonderful! (2,770 reviews)

"I enjoyed my stay and would happily return if I’m in the area."

Reviewed on Aug 6, 2026

Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA

Fully refundableReserve now, pay when you stay

$285 nightly

$328 total

Aug 30 - Aug 31

Total with taxes and fees

This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...

8.8/10 Excellent! (2,805 reviews)

"My key stopped working but everything else was good. Very expensive though to be on the water."

Reviewed on Aug 6, 2026

Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA

Fully refundableReserve now, pay when you stay

$182 nightly

$211 total

Aug 12 - Aug 13

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...

8.4/10 Very Good! (6,259 reviews)

"They have hidden fees that they will tell you once you put down your $300 deposit that they don’t have to tell you about travel fees daily that are $35 plus parking that’s $50 per day so in the end I’ve ended up paying $260 in parking and “travel fee”to them when I’ve already paid through Expedia. ..."

Reviewed on Aug 6, 2026

Omni San Diego Hotel at the Ballpark

675 L St San Diego CA

$190 nightly

$221 total

Aug 24 - Aug 25

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

Hyatt Regency Mission Bay Spa and Marina

1441 Quivira Rd San Diego CA

Fully refundableReserve now, pay when you stay

$255 nightly

$293 total

Sep 1 - Sep 2

Total with taxes and fees

This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.4/10 Very Good! (1,637 reviews)

"Two pools were closed, and AC was not working in the room. Was not notified by staff upon checking in about the closure of pools or paying for parking. Will not be coming back. Hotel rooms were also very old."

Reviewed on Aug 6, 2026

Gaylord Pacific Resort & Convention Center

1000 H Street Chula Vista CA

Fully refundableReserve now, pay when you stay

$340 nightly

$394 total

Sep 3 - Sep 4

Total with taxes and fees

A full-service spa, 8 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...

8.8/10 Excellent! (510 reviews)

"Everything was supper bad I would say charges $65 per day for valet stuff wasn't helpful no housekeeping they dont don't clean room at all bad experience. But good restaurants good food good service pool is good as well but they wrste part clean room and bed"

Reviewed on Aug 6, 2026

Hard Rock Hotel San Diego

207 5th Ave San Diego CA

Fully refundableReserve now, pay when you stay

$226 nightly

$262 total

Aug 12 - Aug 13

Total with taxes and fees

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...

Sheraton San Diego Resort

1380 Harbor Island Dr San Diego CA

Fully refundableReserve now, pay when you stay

$169 nightly

$194 total

Aug 23 - Aug 24

Total with taxes and fees

A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...

Hilton San Diego Bayfront

1 Park Blvd San Diego CA

$213 nightly

$248 total

Sep 6 - Sep 7

Total with taxes and fees

This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Families will appreciate the children's pool and onsite laundry facilities. Enjoy the outdoor ...

8.6/10 Excellent! (2,327 reviews)

"Staff was just ok. Room smelled musky. Air wasn't on when we got into our room. The soap hadn't been refilled and the tv wasn't working. We arrived around 6pm and went straight to the pool. The pool area was really dirty with trash overflowing from the trash cans. When I responded to the text they ..."

Reviewed on Aug 6, 2026

San Diego Marriott Mission Valley

8757 Rio San Diego Dr San Diego CA

Fully refundableReserve now, pay when you stay

$169 nightly

$194 total

Aug 23 - Aug 24

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 30 conference rooms, business center, and express ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.