Explore top 2025 4 Star Hotels in Otay Mesa

Name: Courtyard by Marriott San Diego Downtown Little Italy
Price range: $141 total
Rating: 8

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Top Otay Mesa 4 Star hotels

Manchester Grand Hyatt San Diego

1 Market Pl, San Diego, CA

Fully refundableReserve now, pay when you stay

$266 nightly

$308 total

Oct 31 - Nov 1

Total with taxes and fees

This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (2,855 reviews)

We had a studio suite on the 38th floor and the view was amazing. It was a nice, spacious room, but the bathroom was so tiny and the bed was not very comfortable. The bellman mentioned that there are upgrades planned in the near future though...

Reviewed on Oct 17, 2025

San Diego Marriott Gaslamp Quarter

660 K St, San Diego, CA

Fully refundableReserve now, pay when you stay

$169 nightly

$196 total

Nov 23 - Nov 24

Total with taxes and fees

A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, express ...

8.6/10 Excellent! (1,575 reviews)

Shout out to Christian and Jesse. Jesse helped us in the evening and Christian was knocking it out of the park in the day. Needless to say the both made me not want to leave lol, very great individuals and professionals.

Reviewed on Oct 21, 2025

Wyndham San Diego Bayside

1355 N Harbor Drive, San Diego, CA

Fully refundableReserve now, pay when you stay

$160 nightly

$186 total

Oct 26 - Oct 27

Total with taxes and fees

This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

8.2/10 Very Good! (5,991 reviews)

Older property but great location. Friendly staff and lots nearby.

Reviewed on Oct 20, 2025

Hard Rock Hotel San Diego

207 5th Ave, San Diego, CA

Fully refundableReserve now, pay when you stay

$201 nightly

$232 total

Nov 23 - Nov 24

Total with taxes and fees

A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...

8.8/10 Excellent! (3,037 reviews)

Clean rooms, great staf, convenient to restaurant's, ferry to coronado island and train system

Reviewed on Oct 18, 2025

Hyatt Regency Mission Bay Spa and Marina

1441 Quivira Rd, San Diego, CA

Fully refundableReserve now, pay when you stay

$215 nightly

$247 total

Oct 26 - Oct 27

Total with taxes and fees

This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...

8.4/10 Very Good! (1,547 reviews)

We had a great time, and we really appreciate the staff for keeping everything clean. Thanks to everyone at the front desk, housekeeping, and Red Marlin for taking such good care of us!

Reviewed on Oct 12, 2025

Palihotel San Diego Gaslamp Quarter

830 Sixth Avenue, San Diego, CA

Fully refundableReserve now, pay when you stay

$119 nightly

$139 total

Nov 5 - Nov 6

Total with taxes and fees

This hotel features a restaurant and 2 bars/lounges. WiFi in public areas is free. Valet parking, a coffee shop, and dry cleaning are also offered.

8.6/10 Excellent! (1,927 reviews)

While the staff was very nice & helpful, the rooms are very small-smaller than I expected after choosing a room online. The bathroom showed signs of wear. We heard every door on the floor slam shut each night. Bed was comfy and room clean.

Reviewed on Oct 19, 2025

Hotel del Coronado, Curio Collection by Hilton

1500 Orange Ave, Coronado, CA

Fully refundableReserve now, pay when you stay

$377 nightly

$419 total

Oct 29 - Oct 30

Total with taxes and fees

A private beach, 6 restaurants, and an outdoor pool are all featured at this Victorian resort. Relax with sun loungers and beach umbrellas, and cool off with ...

8/10 Very Good! (1,022 reviews)

We had a secluded poolside room with cabana. It was very pleasant to lay out scantily dressed on the sofa and having a nice cup of coffee first thing in the morning! It's a beautiful hotel rich with history. My boyfriend checked this off his bucket list and we had the best vacation together in beautiful ...

Reviewed on Oct 18, 2025

Hilton San Diego Mission Valley

901 Camino Del Rio S, San Diego, CA

Fully refundableReserve now, pay when you stay

$114 nightly

$131 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

8/10 Very Good! (2,086 reviews)

Something was going on at the hotel and it smelled like poop all over the place.

Reviewed on Oct 20, 2025

InterContinental San Diego by IHG

901 Bayfront Court, San Diego, CA

Fully refundable

$257 nightly

$298 total

Nov 22 - Nov 23

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, laundry ...

9/10 Wonderful! (1,063 reviews)

I loved how there was a starbucks and so many walkable restaurants in the area. I will say parking was very limited since we do have a tall truck but the staff was super understanding and flexible. Absolutely would return.

Reviewed on Oct 18, 2025

Courtyard by Marriott San Diego Downtown Little Italy

1646 Front St, San Diego, CA

Fully refundable

$122 nightly

$141 total

Nov 23 - Nov 24

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and free internet ...

8/10 Very Good! (1,120 reviews)

Amazing staff! From front desk to dinning and bar area! Safe area, walking distance to restaurants

Reviewed on Oct 20, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.