Find a Hotel in Uptown - Upper Duval
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Top hotels in Uptown - Upper Duval

Douglas House - Adults Only
"This place is so cute. It's location is perfect. The staff was amazing. We can not wait to come back"
Reviewed on Nov 14, 2026

H2O Suites - Adults Only
"A beautiful property, wonderful room, great amenities (muffins…yumm). Latoya who checked us in was top notch. Hotel location is also good for navigating to the main Key West attractions. Hits every button."
Reviewed on Nov 11, 2026

Orchid Key Inn - Adults Only
"Always enjoy our stay here. The drink selection at the bar are fantastic and the drinks themselves are delicious. Very clean property. A lot of attention to detail here"
Reviewed on Nov 12, 2026

Santa Maria Suites
"Check in was easy. Staff is extremely friendly and accommodating. The rooms and surrounding pools and grounds were very clean. Easy parking. On site restaurant (Italian) is beautiful...clean, modern, friendly and fantastic food. Great location....coffee shop/deli, scooter rental, bar, ice cream and ..."
Reviewed on Nov 11, 2026

Southernmost House - Adult Exclusive
"Stunning, I dont have to say anymore"
Reviewed on Nov 10, 2026

Southwinds Motel
"Great location walking distance to everything. Quiet, clean property. Continental breakfast was a great start to day. Has a bar on site with music daily great way to unwind and not go far. Very nice clean pools"
Reviewed on Nov 13, 2026

Southernmost Beach Resort and Guesthouses

The Southernmost Inn - Adults Only

The Reach Key West, Curio Collection by Hilton
Uptown - Upper Duval Hotel Guide
Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.
Nowhere else can you find better deals on Uptown - Upper Duval area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Uptown - Upper Duval to find the perfect one to will fit your budget.
Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Uptown - Upper Duval are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.
Recent Uptown - Upper Duval hotel reviews by fellow wanderers

Douglas House - Adults Only
"This place is so cute. It's location is perfect. The staff was amazing. We can not wait to come back"
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