Explore top 2026 5 Star Hotels in Otay Mesa

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Nov 20 - Nov 22
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Nov 27 - Nov 29

Top Otay Mesa 5 Star hotels

Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street San Diego CA
Fully refundableReserve now, pay when you stay
$342 nightly
The price is $397 total per night from Dec 6 to Dec 7
$397 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
Opens in a new windowPendry San Diego
The US Grant, a Luxury Collection Hotel, San Diego

The US Grant, a Luxury Collection Hotel, San Diego

5 out of 5
326 Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $305 total per night from Dec 1 to Dec 2
$305 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...
9/10 Wonderful! (1,001 reviews)
"Location, staff"

Reviewed on Nov 1, 2026

Opens in a new windowThe US Grant, a Luxury Collection Hotel, San Diego
The Bower Coronado

The Bower Coronado

5 out of 5
1417 Orange Ave Coronado CA
Fully refundableReserve now, pay when you stay
$329 nightly
The price is $363 total per night from Nov 16 to Nov 17
$363 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
Opens in a new windowThe Bower Coronado
Shore House at The Del, LXR Hotels & Resorts

Shore House at The Del, LXR Hotels & Resorts

5 out of 5
1500 Orange Avenue Coronado CA
$692 nightly
The price is $769 total per night from Nov 22 to Nov 23
$769 total
Nov 22 - Nov 23
Total with taxes and fees
A private beach, 7 restaurants, and 2 outdoor pools are all featured at this luxury resort. Relax with beach cabanas and sun loungers, and cool off with a drink ...
Opens in a new windowShore House at The Del, LXR Hotels & Resorts
Beach Village at The Del, LXR Hotels & Resorts

Beach Village at The Del, LXR Hotels & Resorts

5 out of 5
1500 Orange Avenue Coronado CA
$789 nightly
The price is $868 total per night from Nov 29 to Nov 30
$868 total
Nov 29 - Nov 30
Total with taxes and fees
A private beach, 7 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Relax with beach cabanas and sun loungers, and cool off with ...
9.2/10 Wonderful! (150 reviews)
"海滩非常漂亮，沙滩很宽，沙子应该是南加州最干净最软的了。 酒店房间很宽敞， 床品非常舒服， 床垫的软硬度极好。 双Queen的床， 还有沙发床， 非常适合一家人出行。早餐的view也是绝美，水果很新鲜。很满意的一次出行， 期待下次回来！ 强烈推荐"

Reviewed on Nov 13, 2026

Opens in a new windowBeach Village at The Del, LXR Hotels & Resorts
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Recent Otay Mesa hotel reviews by fellow wanderers

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

4 out of 5
Posted 8 hours ago
Travelocity Verified Review
"Very good breakfast and clean room."
A verified traveler stayed at The Alcala Hotel Mission Valley/Seaworld
The Alcala Hotel Mission Valley/Seaworld

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