Explore top 2026 5 Star Hotels in Otay Mesa
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Top Otay Mesa 5 Star hotels

Pendry San Diego
550 J Street San Diego CA
Fully refundableReserve now, pay when you stay
$340 nightly
The price is $395 total per night from Feb 22 to Feb 23
$395 total
Feb 22 - Feb 23
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,002 reviews)
Good hotel
Reviewed on Jan 22, 2026

The US Grant, a Luxury Collection Hotel, San Diego
326 Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$265 nightly
The price is $308 total per night from Feb 16 to Feb 17
$308 total
Feb 16 - Feb 17
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...
9/10 Wonderful! (1,001 reviews)
Staff was very welcoming. Room was clean and large. Only negative is reservation said city view and our view was an old building across street that was empty, perhaps receiving some rehab. I guess that was the view of the city, but i inferred city view on reservation suggested our room would have ...
Reviewed on Jan 19, 2026

Shore House at The Del, LXR Hotels & Resorts
1500 Orange Avenue Coronado CA
$619 nightly
The price is $687 total per night from Feb 3 to Feb 4
$687 total
Feb 3 - Feb 4
Total with taxes and fees
A private beach, 7 restaurants, and 2 outdoor pools are all featured at this luxury resort. Relax with beach cabanas and sun loungers, and cool off with a drink ...
9.2/10 Wonderful! (119 reviews)
Luxurious
Reviewed on Dec 29, 2025

Beach Village at The Del, LXR Hotels & Resorts
1500 Orange Avenue Coronado CA
$783 nightly
The price is $862 total per night from Feb 9 to Feb 10
$862 total
Feb 9 - Feb 10
Total with taxes and fees
A private beach, 7 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy beachfront dining and relax with beach cabanas and sun ...
9/10 Wonderful! (125 reviews)
Great staff great room. All and all a perfect 10
Reviewed on Jan 14, 2026

The Bower Coronado
1417 Orange Ave Coronado CA
Fully refundableReserve now, pay when you stay
$349 nightly
The price is $379 total per night from Jan 30 to Jan 31
$379 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
9.2/10 Wonderful! (170 reviews)
Breakfast isn’t included. The property and the staff were top notch. Location is perfect
Reviewed on Jan 20, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Otay Mesa hotel reviews by fellow wanderers

The Dana on Mission Bay
5 out of 5
Posted 23 hours ago
Travelocity Verified Review
"Excellent rooms and beautiful resort. Great staff and service."
A verified traveler stayed at The Dana on Mission Bay
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