Book a hotel near Florida Keys National Marine Sanctuary, Key West

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Top hotels close to Florida Keys National Marine Sanctuary

The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only

3 out of 5
413 Applerouth Lane Key West FL
0.42 mi from Florida Keys National Marine Sanctuary
$203 nightly
The price is $229 total per night
$229 total
May 10 - May 11
Total with taxes and fees
This guesthouse features an outdoor pool and a hot tub. Enjoy the free continental breakfast each morning. Self parking, a terrace, and a garden are also offered.
Pool
Hot Tub
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
0.49 mi from Florida Keys National Marine Sanctuary
$220 nightly
The price is $244 total per night
$244 total
Apr 28 - Apr 29
Total with taxes and fees
This bed & breakfast features a terrace, concierge services, and self parking. A garden, a picnic area, and express check-in are also on offer.
Air conditioning
Parking available
La Concha Key West, Autograph Collection

La Concha Key West, Autograph Collection

4 out of 5
430 Duval St Key West FL
Free Cancellation
Reserve now, pay when you stay
0.5 mi from Florida Keys National Marine Sanctuary
$310 nightly
The price is $349 total per night
$349 total
May 10 - May 11
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and valet parking. There's a poolside bar on site, and a 24-hour front desk and concierge services are also provided.
Pool
Pet friendly
Douglas House - Adults Only

Douglas House - Adults Only

3 out of 5
419 Amelia St Key West FL
0.56 mi from Florida Keys National Marine Sanctuary
$217 nightly
The price is $244 total per night
$244 total
May 4 - May 5
Total with taxes and fees
An outdoor pool is featured at this guesthouse, along with free WiFi in public areas and a terrace. A garden, a picnic area, and luggage storage are also on offer.
Pool
Free WiFi
Heron House - Adult Only

Heron House - Adult Only

3.5 out of 5
512 Simonton St Key West FL
0.56 mi from Florida Keys National Marine Sanctuary
$174 nightly
The price is $196 total per night
$196 total
Apr 28 - Apr 29
Total with taxes and fees
This bed & breakfast features an outdoor pool and a rooftop terrace. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A garden, luggage storage, and concierge services are also on offer.
Pool
Breakfast included
Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West

4 out of 5
245 Front Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.57 mi from Florida Keys National Marine Sanctuary
$304 nightly
The price is $342 total per night
$342 total
May 3 - May 4
Total with taxes and fees
A marina, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the outdoor pool and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub
The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only

3 out of 5
525 United Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.7 mi from Florida Keys National Marine Sanctuary
$264 nightly
The price is $297 total per night
$297 total
May 10 - May 11
Total with taxes and fees
This hotel's 2 outdoor pools and hot tub are among the featured amenities. Enjoy the free continental breakfast each morning. Self parking, a coffee shop, and a terrace are also offered.
Pool
Hot Tub
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.71 mi from Florida Keys National Marine Sanctuary
$330 nightly
The price is $372 total per night
$372 total
May 19 - May 20
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, along with dry cleaning/laundry services.
Pool
Spa
Pier House Resort & Spa

Pier House Resort & Spa

4 out of 5
1 Duval St Key West FL
Free Cancellation
Reserve now, pay when you stay
0.73 mi from Florida Keys National Marine Sanctuary
$595 nightly
The price is $669 total per night
$669 total
May 10 - May 11
Total with taxes and fees
This smoke-free resort features a private beach, a full-service spa, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, business center, and express check-in.
On private beach
Pool
NYAH Key West - Adults Only

NYAH Key West - Adults Only

3 out of 5
420 Margaret Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.84 mi from Florida Keys National Marine Sanctuary
$178 nightly
The price is $201 total per night
$201 total
May 10 - May 11
Total with taxes and fees
This guesthouse's 3 outdoor pools and a rooftop terrace are among the featured amenities. Enjoy the hot tub and free continental breakfast each morning. There's a bar/lounge on site, and a 24-hour front desk and concierge services are also provided.
Pool
Hot Tub
The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton

4 out of 5
1435 Simonton Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.85 mi from Florida Keys National Marine Sanctuary
$330 nightly
The price is $371 total per night
$371 total
May 4 - May 5
Total with taxes and fees
This resort features a private beach, a full-service spa, and a restaurant. Traveling on business? Take advantage of the express check-out, laundry service, and valet parking. Enjoy the outdoor pool and unwind at the bar/lounge and poolside bar.
On private beach
Pool
Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton

4 out of 5
1500 Reynolds Street Key West FL
Free Cancellation
Reserve now, pay when you stay
1.09 mi from Florida Keys National Marine Sanctuary
$377 nightly
The price is $424 total per night
$424 total
May 3 - May 4
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off with a drink at the beachside bar. Enjoy the gym and perks like free WiFi.
On private beach
Pool
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Florida Keys National Marine Sanctuary hotels essential information

Accommodation
2,666 hotels
Lowest Price
$196
Highest Price
$669
Popular hotels
Southernmost Beach Resort and Guesthouses, La Concha Key West, Autograph Collection, Pier House Resort & Spa, Opal Key Resort & Marina, Key West, Casa Marina Key West, Curio Collection by Hilton, The Cabana Inn Key West - Adults Only, The Southernmost Inn - Adults Only, NYAH Key West - Adults Only, Duval House, Heron House - Adult Only, Douglas House - Adults Only, The Reach Key West, Curio Collection by Hilton

Recent Florida Keys National Marine Sanctuary hotel reviews by fellow wanderers

Duval House

Duval House

5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Is a great location "
A verified traveler stayed at Duval House
Duval House

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