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Top hotels close to Florida Keys National Marine Sanctuary

The Cabana Inn Key West - Adults Only
413 Applerouth Lane Key West FL
Free Cancellation
Reserve now, pay when you stay
0.42 mi from Florida Keys National Marine Sanctuary
$211 nightly
The price is $237 total per night
$237 total
May 27 - May 28
Total with taxes and fees
This guesthouse features an outdoor pool and a hot tub. Enjoy the free continental breakfast each morning. Self parking, a terrace, and a garden are also offered.
Pool
Hot Tub

Pegasus International Hotel
501 Southard Street Key West FL
0.48 mi from Florida Keys National Marine Sanctuary
$220 nightly
The price is $248 total per night
$248 total
May 10 - May 11
Total with taxes and fees
This hotel features an outdoor pool and a rooftop terrace. Enjoy the hot tub and free perks like continental breakfast and free self parking. Free WiFi in public areas, a terrace, and concierge services are also on offer.
Pool
Hot Tub

Duval House
815 Duval St Key West FL
0.49 mi from Florida Keys National Marine Sanctuary
$199 nightly
The price is $221 total per night
$221 total
May 10 - May 11
Total with taxes and fees
This bed & breakfast features a terrace, concierge services, and self parking. A garden, a picnic area, and express check-in are also on offer.
Air conditioning
Parking available

La Concha Key West, Autograph Collection
430 Duval St Key West FL
Free Cancellation
Reserve now, pay when you stay
0.5 mi from Florida Keys National Marine Sanctuary
$259 nightly
The price is $291 total per night
$291 total
May 25 - May 26
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and valet parking. There's a poolside bar on site, and a 24-hour front desk and concierge services are also provided.
Pool
Pet friendly

Opal Key Resort & Marina, Key West
245 Front Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.57 mi from Florida Keys National Marine Sanctuary
$294 nightly
The price is $331 total per night
$331 total
May 25 - May 26
Total with taxes and fees
A marina, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the outdoor pool and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub

The Southernmost Inn - Adults Only
525 United Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.7 mi from Florida Keys National Marine Sanctuary
$239 nightly
The price is $269 total per night
$269 total
May 10 - May 11
Total with taxes and fees
This hotel's 2 outdoor pools and hot tub are among the featured amenities. Enjoy the free continental breakfast each morning. Self parking, a coffee shop, and a terrace are also offered.
Pool
Hot Tub

Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
Free Cancellation
0.71 mi from Florida Keys National Marine Sanctuary
$283 nightly
The price is $319 total per night
$319 total
May 25 - May 26
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, along with dry cleaning/laundry services.
Pool
Spa

Pier House Resort & Spa
1 Duval St Key West FL
Free Cancellation
Reserve now, pay when you stay
0.73 mi from Florida Keys National Marine Sanctuary
$381 nightly
The price is $429 total per night
$429 total
May 25 - May 26
Total with taxes and fees
This smoke-free resort features a private beach, a full-service spa, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, business center, and express check-in.
On private beach
Pool

Southwinds Motel
1321 Simonton Street Key West FL
0.77 mi from Florida Keys National Marine Sanctuary
$194 nightly
The price is $218 total per night
$218 total
Jun 2 - Jun 3
Total with taxes and fees
This hotel features 2 outdoor pools and a bar/lounge. Enjoy the free continental breakfast each morning. Self parking, a picnic area, and luggage storage are also offered.
Pool
Breakfast included

NYAH Key West - Adults Only
420 Margaret Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.84 mi from Florida Keys National Marine Sanctuary
$172 nightly
The price is $194 total per night
$194 total
Jun 1 - Jun 2
Total with taxes and fees
This guesthouse's 3 outdoor pools and a rooftop terrace are among the featured amenities. Enjoy the hot tub and free continental breakfast each morning. There's a bar/lounge on site, and a 24-hour front desk and concierge services are also provided.
Pool
Hot Tub

The Reach Key West, Curio Collection by Hilton
1435 Simonton Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.85 mi from Florida Keys National Marine Sanctuary
$267 nightly
The price is $301 total per night
$301 total
May 25 - May 26
Total with taxes and fees
This resort features a private beach, a full-service spa, and a restaurant. Traveling on business? Take advantage of the express check-out, laundry service, and valet parking. Enjoy the outdoor pool and unwind at the bar/lounge and poolside bar.
On private beach
Pool

Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street Key West FL
Free Cancellation
Reserve now, pay when you stay
1.09 mi from Florida Keys National Marine Sanctuary
$327 nightly
The price is $368 total per night
$368 total
May 25 - May 26
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off with a drink at the beachside bar. Enjoy the gym and perks like free WiFi.
On private beach
Pool
Don't see what you're looking for?
See all available properties in Florida Keys National Marine Sanctuary
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Florida Keys National Marine Sanctuary hotels essential information
Accommodation | 2,671 hotels |
|---|---|
Lowest Price | $194 |
Highest Price | $429 |
Popular hotels | Southernmost Beach Resort and Guesthouses, Opal Key Resort & Marina, Key West, Pier House Resort & Spa, Casa Marina Key West, Curio Collection by Hilton, The Cabana Inn Key West - Adults Only, La Concha Key West, Autograph Collection, The Southernmost Inn - Adults Only, NYAH Key West - Adults Only, Pegasus International Hotel, Duval House, Southwinds Motel, The Reach Key West, Curio Collection by Hilton |
Recent Florida Keys National Marine Sanctuary hotel reviews by fellow wanderers

Southwinds Motel
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Basic ROOM but FANASTIC location"
A verified traveler stayed at Southwinds Motel
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