Book a hotel near Florida Keys National Marine Sanctuary, Key West
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Top hotels close to Florida Keys National Marine Sanctuary

Caribbean House
226 Petronia St Key West FL
0.29 mi from Florida Keys National Marine Sanctuary
$136 nightly
The price is $150 total per night
$150 total
Jun 24 - Jun 25
Total with taxes and fees
This bed & breakfast features free WiFi in public areas, concierge services, and self parking. Enjoy the free local cuisine breakfast each morning. A terrace, express check-in, and express check-out are also on offer.
Breakfast included
Free WiFi

The Cabana Inn Key West - Adults Only
413 Applerouth Lane Key West FL
Free Cancellation
Reserve now, pay when you stay
0.42 mi from Florida Keys National Marine Sanctuary
$167 nightly
The price is $188 total per night
$188 total
Jun 25 - Jun 26
Total with taxes and fees
This guesthouse features an outdoor pool and a hot tub. Enjoy the free continental breakfast each morning. Self parking, a terrace, and a garden are also offered.
Pool
Hot Tub

Duval House
815 Duval St Key West FL
0.49 mi from Florida Keys National Marine Sanctuary
$120 nightly
The price is $132 total per night
$132 total
Jun 29 - Jun 30
Total with taxes and fees
This bed & breakfast features a terrace, concierge services, and self parking. A garden, a picnic area, and express check-in are also on offer.
Air conditioning
Parking available

Wicker Guesthouse
913 Duval Street Key West FL
0.5 mi from Florida Keys National Marine Sanctuary
$209 nightly
The price is $235 total per night
$235 total
Jun 24 - Jun 25
Total with taxes and fees
This guesthouse features an outdoor pool and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, a garden, and a library are also on offer.
Pool
Breakfast included

La Concha Key West, Autograph Collection
430 Duval St Key West FL
Free Cancellation
Reserve now, pay when you stay
0.5 mi from Florida Keys National Marine Sanctuary
$216 nightly
The price is $243 total per night
$243 total
Jul 6 - Jul 7
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-out, and valet parking. There's a poolside bar on site, and a 24-hour front desk and concierge services are also provided.
Pool
Pet friendly

Douglas House - Adults Only
419 Amelia St Key West FL
0.56 mi from Florida Keys National Marine Sanctuary
$105 nightly
The price is $118 total per night
$118 total
Jul 19 - Jul 20
Total with taxes and fees
An outdoor pool is featured at this guesthouse, along with free WiFi in public areas and a terrace. A garden, a picnic area, and luggage storage are also on offer.
Pool
Free WiFi

Opal Key Resort & Marina, Key West
245 Front Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.57 mi from Florida Keys National Marine Sanctuary
$294 nightly
The price is $331 total per night
$331 total
Jun 28 - Jun 29
Total with taxes and fees
A marina, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the outdoor pool and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub

The Southernmost Inn - Adults Only
525 United Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.7 mi from Florida Keys National Marine Sanctuary
$162 nightly
The price is $182 total per night
$182 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel's 2 outdoor pools and hot tub are among the featured amenities. Enjoy the free continental breakfast each morning. Self parking, a coffee shop, and a terrace are also offered.
Pool
Hot Tub

Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
Free Cancellation
Reserve now, pay when you stay
0.71 mi from Florida Keys National Marine Sanctuary
$266 nightly
The price is $299 total per night
$299 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, along with dry cleaning/laundry services.
Pool
Spa

Pier House Resort & Spa
1 Duval St Key West FL
0.73 mi from Florida Keys National Marine Sanctuary
$344 nightly
The price is $387 total per night
$387 total
Jul 6 - Jul 7
Total with taxes and fees
This smoke-free resort features a private beach, a full-service spa, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, business center, and express check-in.
On private beach
Pool

Southwinds Motel
1321 Simonton Street Key West FL
0.77 mi from Florida Keys National Marine Sanctuary
$175 nightly
The price is $196 total per night
$196 total
Jun 24 - Jun 25
Total with taxes and fees
This hotel features 2 outdoor pools and a bar/lounge. Enjoy the free continental breakfast each morning. Self parking, a picnic area, and luggage storage are also offered.
Pool
Breakfast included

Hyatt Centric Key West Resort and Spa
601 Front St Key West FL
Free Cancellation
Reserve now, pay when you stay
0.8 mi from Florida Keys National Marine Sanctuary
$253 nightly
The price is $285 total per night
$285 total
Jun 29 - Jun 30
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and a restaurant. Enjoy the outdoor pool and perks like free WiFi. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.
Pool
Spa
Don't see what you're looking for?
See all available properties in Florida Keys National Marine Sanctuary
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Florida Keys National Marine Sanctuary hotels essential information
Accommodation | 2,617 hotels |
|---|---|
Lowest Price | $118 |
Highest Price | $387 |
Popular hotels | Southernmost Beach Resort and Guesthouses, La Concha Key West, Autograph Collection, Pier House Resort & Spa, Hyatt Centric Key West Resort and Spa, Opal Key Resort & Marina, Key West, Caribbean House, The Cabana Inn Key West - Adults Only, Duval House, Southwinds Motel, Wicker Guesthouse, Douglas House - Adults Only, The Southernmost Inn - Adults Only |
Recent Florida Keys National Marine Sanctuary hotel reviews by fellow wanderers

Southernmost Beach Resort and Guesthouses
5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Clean room Pools Staff very friendly"
A verified traveler stayed at Southernmost Beach Resort and Guesthouses
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