Explore top 2025 5 Star Hotels in Otay Mesa

Start date: Check-in selected.
To Date
End date: Check-out

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Top Otay Mesa 5 Star hotels

Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street, San Diego, CA
Fully refundableReserve now, pay when you stay
$295 nightly
The price is $342 total per night from Nov 23 to Nov 24
$342 total
Nov 23 - Nov 24
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.2/10 Wonderful! (1,019 reviews)
The room was perfect, the shower soap, and lotions smelled so good I bought some to take home. Beautiful hotel and easy to walk around gaslamp without need for uber. Walkable to train and trolly also! The hotel bar was very classy and staff went above and beyond!

Reviewed on Oct 15, 2025

Opens in a new windowPendry San Diego
The US Grant, a Luxury Collection Hotel, San Diego

The US Grant, a Luxury Collection Hotel, San Diego

5 out of 5
326 Broadway, San Diego, CA
Fully refundableReserve now, pay when you stay
$260 nightly
The price is $302 total per night from Nov 23 to Nov 24
$302 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, express check-out, and ...
9/10 Wonderful! (1,000 reviews)
Location is a bit shady as that part of town has seen better times. Valet parking and bell service are excellent. Room condition was good, except for some old food left on carpet. Water pressure so-so. Room orientation very nice. Oddly they have no internet. The gym was nice, a couple of elliptical ...

Reviewed on Oct 14, 2025

Opens in a new windowThe US Grant, a Luxury Collection Hotel, San Diego
The Bower Coronado

The Bower Coronado

5 out of 5
1417 Orange Ave, Coronado, CA
Fully refundableReserve now, pay when you stay
$302 nightly
The price is $327 total per night from Nov 17 to Nov 18
$327 total
Nov 17 - Nov 18
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
9/10 Wonderful! (117 reviews)
Amazing New Addition in Town !!
I was very pleasantly surprised by the level of quality at this hotel. No noise in the rooms, and the hallways are quiet and well-insulated thanks to the carpeted floors. The room was beautifully decorated, the bedding excellent, and the bathroom very comfortable. A special touch: the Santal 33 by ...

Reviewed on Oct 13, 2025

Opens in a new windowThe Bower Coronado
Beach Village at The Del, LXR Hotels & Resorts

Beach Village at The Del, LXR Hotels & Resorts

5 out of 5
1500 Orange Avenue, Coronado, CA
$783 nightly
The price is $863 total per night from Nov 5 to Nov 6
$863 total
Nov 5 - Nov 6
Total with taxes and fees
A private beach, 7 restaurants, and 3 outdoor pools are all featured at this smoke-free resort. Enjoy beachfront dining and relax with beach cabanas and sun ...
9/10 Wonderful! (118 reviews)
We had a wonderful view of the beach although it was partially obstructed.

Reviewed on Oct 13, 2025

Opens in a new windowBeach Village at The Del, LXR Hotels & Resorts
Don't see what you're looking for?
See all available properties in Otay Mesa
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Otay Mesa hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity