Explore the best 2025 4 Star Hotels Hotels in Lower Florida Keys

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Top Lower Florida Keys 4 Star hotels

Southernmost Beach Resort and Guesthouses

1319 Duval Street, Key West, FL

Free Cancellation

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This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling for business? Take advantage of the 24-hour business center, laundry service, and conference space.

Pool

Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West, FL

Free Cancellation

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This eco-certified resort features a full-service spa, a marina, and a restaurant. Enjoy the outdoor pool and perks like free WiFi. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Pool

Spa

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West, FL

Free Cancellation

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A marina, 6 outdoor pools, and a 24-hour gym are all featured at this smoke-free hotel. Business travelers can take advantage of the free WiFi in public areas. The restaurant provides options for dining, while the bar/lounge and poolside bar are great spots to unwind.

Pool

Pet friendly

Margaritaville Beach House Key West

2001 South Roosevelt Boulevard, Key West, FL

Free Cancellation

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This hotel features a restaurant, an outdoor pool, and a bar/lounge. If you want to take your pet along, this pet-friendly property offers everything you'll need for your pet including food and water bowls. There's a 24-hour gym on site, and a 24-hour front desk and dry cleaning are also provided.

Pool

Pet friendly

Blue Flamingo Resort Key West

3820 North Roosevelt Boulevard, Key West, FL

Free Cancellation

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This eco-certified hotel features 2 restaurants, 2 outdoor pools, and a 24-hour gym. There's fun for all ages with mini golf and an arcade/game room, and families will appreciate the onsite laundry facilities. Unwind with a drink at one of the 2 poolside bars and enjoy freebies like WiFi in public areas and an area shuttle.

Pool

Pet friendly

Casa Marina Key West, Curio Collection by Hilton

1500 Reynolds Street, Key West, FL

Free Cancellation

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A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off with a drink at the beachside bar. Enjoy the gym and perks like free WiFi.

On private beach

Pool

Havana Cabana at Key West

3420 N. Roosevelt Blvd, Key West, FL

Free Cancellation

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This hotel features a restaurant, an outdoor pool, and a bar/lounge. Business travelers can take advantage of the free WiFi in public areas. Enjoy the hot tub and perks like free self parking.

Pool

Hot Tub

The Perry Hotel & Marina Key West

7001 Shrimp Road, Key West, FL

Free Cancellation

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A marina, 2 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling for business? Take advantage of the free WiFi in public areas, laundry service, and conference space. 2 poolside bars and 2 bars/lounges are featured at this hotel, along with a 24-hour gym.

Pool

Pet friendly

Pier House Resort & Spa

1 Duval St, Key West, FL

Free Cancellation

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This smoke-free resort features a private beach, a full-service spa, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling on business? Take advantage of the 2 conference rooms, business center, and express check-in.

On private beach

Pool

DoubleTree Resort by Hilton Grand Key - Key West

3990 S Roosevelt Blvd, Key West, FL

Free Cancellation

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This resort features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport shuttle. Enjoy the 24-hour gym and perks like a free beach shuttle.

Pool

Free airport shuttle

Parrot Key Hotel & Villas

2801 N Roosevelt Blvd, Key West, FL

Free Cancellation

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This eco-certified hotel features 4 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Unwind with a drink at the bar/lounge and enjoy perks like a free area shuttle.

Pool

Free WiFi

The Marker Key West Harbor Resort

200 William Street, Key West, FL

Free Cancellation

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This eco-certified hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. There's a bar/lounge on site, and a 24-hour front desk and concierge services are also provided.

Pool

Pet friendly

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4 Star Hotels Lower Florida Keys

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Lower Florida Keys 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Lower Florida Keys will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Lower Florida Keys, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Lower Florida Keys hotels essential information

Accommodation	3,517 hotels
Lowest Price
Highest Price
Popular hotels	Southernmost Beach Resort and Guesthouses, Hyatt Centric Key West Resort and Spa, Oceans Edge Key West Resort, Hotel & Marina, Margaritaville Beach House Key West, Blue Flamingo Resort Key West, Casa Marina Key West, Curio Collection by Hilton, Havana Cabana at Key West , The Perry Hotel & Marina Key West, Pier House Resort & Spa, DoubleTree Resort by Hilton Grand Key - Key West, Parrot Key Hotel & Villas, The Marker Key West Harbor Resort

Recent Lower Florida Keys hotel reviews by fellow wanderers

Parmer's Resort

5 out of 5

Posted 6 days ago

Travelocity Verified Review

"A wonderful stay! Great staff, service, and rooms! Very comfy bed with lamps on both sides for reading. Great shower and kitchen! Breakfast was much more than “Grab and Go. We held a large family event here and Parmer’s couldn’t be more accommodating. "

A verified traveler stayed at Parmer's Resort