Book Hotels in Pamplico, SC

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Top Pamplico hotels

The Inn at the Crossroads

The Inn at the Crossroads

2 out of 5
128 West Main Street Lake City SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $113 total per night from Aug 31 to Sep 1
$113 total
Aug 31 - Sep 1
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"Great location. A little off the beaten path but clean and neat."

Reviewed on Aug 12, 2026

Opens in a new windowThe Inn at the Crossroads
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

2.5 out of 5
3000 W Radio Dr Florence SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $123 total per night from Aug 23 to Aug 24
$123 total
Aug 23 - Aug 24
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
"👍"

Reviewed on Aug 13, 2026

Opens in a new windowHampton Inn & Suites Florence Center
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $72 total per night from Sep 10 to Sep 11
$72 total
Sep 10 - Sep 11
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Like most HoJos, the thing is the retro-chic interior. Flashbacks to 1970. Older model, but clean and well maintained. The room itself is huge, and spotlessly clean. All towels and shower curtain folded just so. Coffee machine ironing board hair dryer am included. Even taking the discounted fare ..."

Reviewed on Aug 13, 2026

Opens in a new windowHoward Johnson by Wyndham Florence
SpringHill Suites by Marriott Florence

SpringHill Suites by Marriott Florence

3 out of 5
2670 Hospitality Blvd Florence SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $113 total per night from Aug 30 to Aug 31
$113 total
Aug 30 - Aug 31
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free continental ...
"Great place to stay - close /walkable to stores and restaurants."

Reviewed on Aug 12, 2026

Opens in a new windowSpringHill Suites by Marriott Florence
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $104 total per night from Aug 23 to Aug 24
$104 total
Aug 23 - Aug 24
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"The hotel was very nice. Clean, rooms were comfortable, bed was very comfortable. Staff could have been a little more attentive. I waited 10 minutes for a staff member to come to the desk to check us in. Also, when I asked a question, she wasn't very accommodating. She wasn't unprofessional, just ..."

Reviewed on Aug 13, 2026

Opens in a new windowSpark by Hilton Florence North I-95, SC
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Aug 15 to Aug 16
$98 total
Aug 15 - Aug 16
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Opens in a new windowQuality Inn & Suites Florence Civic Center
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Fully refundable
$71 nightly
The price is $80 total per night from Sep 7 to Sep 8
$80 total
Sep 7 - Sep 8
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free ...
Opens in a new windowPark Inn by Radisson Florence, SC
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $128 total per night from Aug 19 to Aug 20
$128 total
Aug 19 - Aug 20
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowHyatt Place Florence Downtown
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Fully refundable
$107 nightly
The price is $120 total per night from Sep 13 to Sep 14
$120 total
Sep 13 - Sep 14
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Opens in a new windowComfort Inn & Suites Florence Center Area
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Pamplico?
Family trips are where you make the best memories, but it's no secret that traveling with young ones can be daunting. These kid-friendly Pamplico hotels come with perks designed to keep travelers of all ages relaxed and happy: Your entourage will enjoy their time at Cheerful home with plenty of privacy and entertainment room.. A fireplace and free WiFi are just a couple of the things that help make this hotel a winner. The Inn at the Crossroads is another excellent choice. After an exciting day of exploring, return to your cozy room and amenities like complimentary breakfast and a pillowtop mattress.
Where can I find cheap hotels in Pamplico?
At Travelocity you'll find really nice hotels in Pamplico at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Pamplico rather than in Pamplico. We may find you even better rates, too.
How do I find the best Pamplico hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Pamplico then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Pamplico?
The cheapest hotel in Pamplico is $72. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Pamplico?
There are 169 hotels in Pamplico on Travelocity.
What are the best hotels in Pamplico?
Pamplico has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Pamplico for you!
When is the best time to visit Pamplico?
If you want the joy of a fun-filled trip in peak season, visit Pamplico during March, April and July. If you'd prefer the peace of off-season, book a stay during quieter months, such as January, September and October.
When is the cheapest time to stay in Pamplico?
Based on historic data is usually the cheapest month to visit Pamplico. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Pamplico?
There are multiple hotels in Pamplico that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Pamplico. We have plenty of kid-friendly hotels in Pamplico to choose from on Travelocity!
Why book a hotel in Pamplico through Travelocity?
Because we have the top hotels in Pamplico! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Pamplico on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Pamplico hotel reviews by fellow wanderers

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Like most HoJos, the thing is the retro-chic interior. Flashbacks to 1970. Older model, but clean and well maintained. The room itself is huge, and spotlessly clean. All towels and shower curtain folded just so. Coffee machine ironing board hair dryer am included. Even taking the discounted fare into account, this was a wonderful overnight stay."
A verified traveler stayed at Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham Florence

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