Book Hotels in Pamplico, SC
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Pamplico hotels

Park Inn by Radisson Florence, SC
1729 Mandeville Road Florence SC
Fully refundable
$76 nightly
The price is $85 total per night from May 25 to May 26
$85 total
May 25 - May 26
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Business travelers can take advantage of the business center. Enjoy ...
The shower in 304 had caked on dirt or pure mold. It was not worth.
Reviewed on May 3, 2026

Comfort Inn & Suites Florence Center Area
527 Woody Jones Blvd Florence SC
Fully refundable
$100 nightly
The price is $112 total per night from May 24 to May 25
$112 total
May 24 - May 25
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
Booked regular suit room, & has been given the room for disability/wheelchair people. We have been said- they have made upgrade for us, as we have been allowed for the upgrade, & room for disability people is considered as an upgrade! Crazy. Will never stay again not only in this hotel, but in chain! ...
Reviewed on May 3, 2026

Hyatt Place Florence Downtown
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $137 total per night from May 10 to May 11
$137 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Friendly staff. Only negative is that the hotel is close to the train station and you can hear trains going by at night. There are several nice restaurants within walking distance.
Reviewed on May 3, 2026

TownePlace Suites by Marriott Florence
2650 Hospitality Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $132 total per night from May 4 to May 5
$132 total
May 4 - May 5
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Great service, clean room, good value.
Reviewed on Apr 27, 2026

Howard Johnson by Wyndham Florence
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $75 total per night from May 24 to May 25
$75 total
May 24 - May 25
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Got there late in the evening and left before breakfast Parking area well lit Staff friendly and professional Room was clean
Reviewed on May 3, 2026

SpringHill Suites by Marriott Florence
2670 Hospitality Blvd Florence SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $119 total per night from May 10 to May 11
$119 total
May 10 - May 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
The staff was Friendly.The room and the property was nice and clean. The kids enjoyed themselves at the indoor pool,while I enjoyed a quick workout in the gym next to the pool.My only gripe is that,the sink by the bathroom had a slow drain.I loved the location of the property also,near the Mall and ...
Reviewed on Apr 27, 2026

Spark by Hilton Florence North I-95, SC
1739 Mandeville Rd Florence SC
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $104 total per night from May 10 to May 11
$104 total
May 10 - May 11
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
The room was clean. Pet and kid friendly. Dogs and kids were barking and giggling in the early hours but nice and quiet later.
Reviewed on May 3, 2026

Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $74 total per night from May 24 to May 25
$74 total
May 24 - May 25
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Room was dirty, breakfast was minimal. Staff was friendly
Reviewed on May 2, 2026

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from May 10 to May 11
$106 total
May 10 - May 11
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Pamplico with star-rating
Check Pamplico Hotels by Star Rating

3 Star Hotels
28 properties
Frequently asked questions
Recent Pamplico hotel reviews by fellow wanderers

Howard Johnson by Wyndham Florence
5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Got there late in the evening and left before breakfast
Parking area well lit
Staff friendly and professional
Room was clean"
A verified traveler stayed at Howard Johnson by Wyndham Florence
Explore More Ways to Travel with Travelocity
- Sellers Hotels
- Aynor Hotels
- Hotels near Magnolia Mall
- 4 Star Hotels in Centenary
- Centenary Hotels
- Coward Hotels
- Vacation Homes in Coward
- Florence Hotels
- Hemingway Hotels
- Hotels near Eastern Carolina Agricultural Fairgrounds
- Hotels near Florence Museum
- Hotels near Florence Civic Center
- Scranton Hotels
- Motels in Scranton
- Myrtle Beach Hotels
- 4 Star Hotels in Marion
- 5 Star Hotels in Marion
- B&B in Marion
- Cabins in Marion
- Condos in Marion
- Extended Stay Hotels in Marion
- Convention Center Hotels in Marion
- Romantic Getaways & Hotels in Marion
- Hotel Wedding Venues Hotels in Marion
- Marion Hotels
- Motels in Marion
- Vacation Homes in Marion
- Apartments in Lake City
- B&B in Lake City
- Extended Stay Hotels in Lake City
- Boutique Hotels in Lake City
- Cheap Hotels in Lake City
- Hotels with Pools in Lake City
- Hotels with Balconies in Lake City
- Pet Friendly Hotels in Lake City
- Lake City Hotels
- Motels in Lake City
- Vacation Homes in Lake City
- Rv Parks in Lake City
- Hotels near Ronald E. McNair Life History Center
- Nesmith Hotels
- Brittons Neck Hotels
- Mullins Hotels
- 3 Star Hotels in Gresham
- Cabins in Gresham
- Cottages in Gresham
- Gresham Hotels
- Motels in Gresham
- Villas in Gresham
- Hotels near The Country Club at Lake City
- Hotels near Mcleod Regional Medical Center
- 3 Star Hotels in Johnsonville
- Cabins in Johnsonville
- Johnsonville Hotels
- Hotels near Florence Motor Speedway
- Cades Hotels
- Galivants Ferry Hotels
- Quinby Hotels
- Hotels near Francis Marion University
- Hotels near Lions Park
- Hotels near Florence Regional
- Hotels near Columns Plantation
- Flights to Marion
- Flights to Johnsonville
- Flights from Florence Regional
- American Airlines Charlotte (CLT) to Florence (FLO) flights
- American Airlines Greenville (GSP) to Florence (FLO) flights
- American Airlines Atlanta (ATL) to Florence (FLO) flights
- American Airlines Cleveland (CLE) to Florence (FLO) flights
- American Airlines New York (JFK) to Florence (FLO) flights
- American Airlines Chicago (ORD) to Florence (FLO) flights
- American Airlines Orlando (MCO) to Florence (FLO) flights
- American Airlines Phoenix (PHX) to Florence (FLO) flights
- American Airlines Tampa (TPA) to Florence (FLO) flights
- Delta Atlanta (ATL) to Florence (FLO) flights
- Delta New York (JFK) to Florence (FLO) flights
- Flights from Hartford (BDL) to Florence (FLO)
- Flights from Nashville (BNA) to Florence (FLO)
- Flights from Boise (BOI) to Florence (FLO)
- Flights from Baltimore (BWI) to Florence (FLO)
- Flights from Newark Liberty Intl. Airport (EWR) to Florence (FLO)
- Flights from Greenville (GSP) to Florence (FLO)
- Flights from Jacksonville (JAX) to Florence (FLO)
- Flights from Lexington (LEX) to Florence (FLO)
- Flights from Philadelphia (PHL) to Florence (FLO)
- Flights from Raleigh (RDU) to Florence (FLO)
- Flights from Fort Myers (RSW) to Florence (FLO)
- Flights from Savannah (SAV) to Florence (FLO)
- Flights from Tampa (TPA) to Florence (FLO)
- Flights from Knoxville (TYS) to Florence (FLO)






