Book Hotels in Pamplico, SC
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Top Pamplico hotels

Comfort Inn & Suites Florence Center Area
527 Woody Jones Blvd Florence SC
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $107 total per night from Feb 1 to Feb 2
$107 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy ...
The staff was friendly and the room was clean.
Reviewed on Jan 19, 2026

Hampton Inn & Suites Florence Center
3000 W Radio Dr Florence SC
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $123 total per night from Jan 30 to Jan 31
$123 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
Breakfast was far could use more options that are healthy . Rooms were very nice and super clean.
Reviewed on Jan 17, 2026

Park Inn by Radisson Florence, SC
1729 Mandeville Road Florence SC
Fully refundable
$85 nightly
The price is $95 total per night from Jan 25 to Jan 26
$95 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Business travelers can take advantage of the business center. Enjoy ...
Good but need better tv
Reviewed on Jan 19, 2026

Hyatt Place Florence Downtown
100 East Evans Street Florence Florence SC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $112 total per night from Feb 2 to Feb 3
$112 total
Feb 2 - Feb 3
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Great location and well maintained property.
Reviewed on Jan 18, 2026

Residence Inn Marriott Florence
2660 Hospitality Blvd Florence SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $111 total per night from Jan 26 to Jan 27
$111 total
Jan 26 - Jan 27
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free continental ...
I gave it four stars because they was a five dollar parking fee that’s charged on the credit card you leave for incidentals I was not aware of the parking fee. We only stayed one night so I guess it’s five dollars per night for parking. Other than that. Everything was great. Rooms were clean. Breakfast ...
Reviewed on Jan 5, 2026

TownePlace Suites by Marriott Florence
2650 Hospitality Boulevard Florence SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $123 total per night from Jan 26 to Jan 27
$123 total
Jan 26 - Jan 27
Total with taxes and fees
This hotel features an outdoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Room was clean and comfortable as a waypoint on our trip. Many choices for a meal nearby. Free breakfast was typical but very well done.
Reviewed on Jan 20, 2026

Howard Johnson by Wyndham Florence
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from Jan 25 to Jan 26
$79 total
Jan 25 - Jan 26
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
It was a great place to stay
Reviewed on Jan 18, 2026

La Quinta Inn & Suites by Wyndham Florence
2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Jan 25 to Jan 26
$106 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Good location, pet friendly
Reviewed on Jan 19, 2026

Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95 Florence SC
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $65 total per night from Feb 20 to Feb 21
$65 total
Feb 20 - Feb 21
Total with taxes and fees
A seasonal outdoor pool, free self parking, and laundry facilities are featured at this motel. Guests will appreciate free perks like on-the-go breakfast and ...
Good room, great price
Reviewed on Jan 17, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Pamplico with star-rating
Check Pamplico Hotels by Star Rating

3 Star Hotels
13 properties
Frequently asked questions
Recent Pamplico hotel reviews by fellow wanderers

TownePlace Suites by Marriott Florence
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Room was clean and comfortable as a waypoint on our trip. Many choices for a meal nearby. Free breakfast was typical but very well done."
A verified traveler stayed at TownePlace Suites by Marriott Florence
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