Explore top 2026 4 Star Hotels in Texas Medical Center

Name: Hilton Houston Plaza/Medical Center
Price range: $123 total
Rating: 8.4

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

5701 Main Street Houston TX

Fully refundableReserve now, pay when you stay

$239 nightly

$279 total

Jul 17 - Jul 18

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,019 reviews)

"Rooms were super musty and mildew smelling. Vents were disgusting, full of mold and dust and dirt. Water damage in the rooms. Beds were lumpy and mediocre. . Sinks were moldy around the grout. Shower backed up with water. Valets scuffed the back of my vehicle. Hotel is old and rundown needs a complete ..."

Reviewed on Jul 12, 2026

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX

Fully refundableReserve now, pay when you stay

$94 nightly

$110 total

Jul 14 - Jul 15

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (4,348 reviews)

"Good location in downtown! Easy check in and check out process."

Reviewed on Jul 13, 2026

Grand Tuscany Hotel

12801 Northwest Fwy Houston TX

Fully refundableReserve now, pay when you stay

$104 nightly

$122 total

Jul 19 - Jul 20

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...

8/10 Very Good! (161 reviews)

"Overall great experience, will definitely be going back!!"

Reviewed on Jul 13, 2026

The Moran CITYCENTRE

800 Sorella Court Houston TX

Fully refundableReserve now, pay when you stay

$204 nightly

$239 total

Jul 19 - Jul 20

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,111 reviews)

"The property is nice. A few things are starting to age and need a little maintenance, but still a very nice place. Only disappointment this time we stayed here was that none of the staff seemed like they wanted to be there. No one was particularly rude, but no one had a smile and every interaction ..."

Reviewed on Jul 11, 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd Houston TX

Fully refundableReserve now, pay when you stay

$123 nightly

$144 total

Jul 31 - Aug 1

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...

8.4/10 Very Good! (4,267 reviews)

"Property was easy to access , clean rooms , breakfast buffet was definitely a 10/10 ! I loved everything about our stay besides the slow elevators and the restaurant was closed I loved everything else about it ."

Reviewed on Jul 13, 2026

Marriott Marquis Houston

1777 Walker Street Houston TX

Fully refundableReserve now, pay when you stay

$233 nightly

$272 total

Jul 30 - Jul 31

Total with taxes and fees

A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9/10 Wonderful! (1,172 reviews)

"N/a"

Reviewed on Jul 12, 2026

Blossom Hotel Houston, Curio Collection by Hilton

7118 Bertner Ave Houston TX

Fully refundableReserve now, pay when you stay

$147 nightly

$172 total

Jul 19 - Jul 20

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (3,857 reviews)

"Loved the place! Did not realize there was a holding fee of $100 a night when I got there and there was no microwave but I later found out I was supposed to request it. Overall, I enjoyed my stay but I just wish I had known these things beforehand"

Reviewed on Jul 13, 2026

Thompson Houston, by Hyatt

1717 ALLEN PARKWAY Houston TX

Fully refundableReserve now, pay when you stay

$249 nightly

$291 total

Jul 26 - Jul 27

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...

9.4/10 Exceptional! (292 reviews)

"The pool area was the best part, and the bartenders"

Reviewed on Jul 9, 2026

The Royal Sonesta Houston Galleria

2222 West Loop South Houston TX

Fully refundableReserve now, pay when you stay

$134 nightly

$157 total

Jul 24 - Jul 25

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...

8.6/10 Excellent! (2,108 reviews)

"The property was awesome"

Reviewed on Jul 13, 2026

Hilton Houston Plaza/Medical Center

6633 Travis St Houston TX

Fully refundableReserve now, pay when you stay

$105 nightly

$123 total

Jul 24 - Jul 25

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...

8.4/10 Very Good! (2,031 reviews)

"The hotel was older, but beautifully maintained. The staff was excellent, everyone was very helpful and accommodating. We would definitely stay again if we're in the area."

Reviewed on Jul 12, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.