Explore top 2026 4 Star Hotels in Texas Medical Center

Name: Hilton Houston Plaza/Medical Center
Price range: $118 total
Rating: 8.4

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

5701 Main Street Houston TX

Fully refundableReserve now, pay when you stay

$239 nightly

$279 total

Jul 13 - Jul 14

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,017 reviews)

"Everything on the property was very great ... we really like the way valet had our car on time when we needed it... we will come again... Thanks for the stay"

Reviewed on Jul 12, 2026

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX

Fully refundableReserve now, pay when you stay

$85 nightly

$99 total

Jul 15 - Jul 16

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (4,342 reviews)

"Quite an underwhelming experience was here for the World Cup and the rooms were not very clean everything was quite dusty."

Reviewed on Jul 11, 2026

Grand Tuscany Hotel

12801 Northwest Fwy Houston TX

Fully refundableReserve now, pay when you stay

$104 nightly

$122 total

Jul 13 - Jul 14

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...

7.8/10 Good! (160 reviews)

"Pool was way too small."

Reviewed on Jul 9, 2026

The Moran CITYCENTRE

800 Sorella Court Houston TX

Fully refundableReserve now, pay when you stay

$188 nightly

$220 total

Jul 19 - Jul 20

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,110 reviews)

"The property is nice. A few things are starting to age and need a little maintenance, but still a very nice place. Only disappointment this time we stayed here was that none of the staff seemed like they wanted to be there. No one was particularly rude, but no one had a smile and every interaction ..."

Reviewed on Jul 11, 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd Houston TX

Fully refundableReserve now, pay when you stay

$123 nightly

$144 total

Jul 31 - Aug 1

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...

8.4/10 Very Good! (4,262 reviews)

"The hotel was clean and vey accommodating. Parking can be a little tricky in and out of the hotel but manageable. Male hostess was vey nice and welcoming."

Reviewed on Jul 12, 2026

Marriott Marquis Houston

1777 Walker Street Houston TX

Fully refundableReserve now, pay when you stay

$233 nightly

$272 total

Jul 30 - Jul 31

Total with taxes and fees

A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9/10 Wonderful! (1,170 reviews)

"Will never stay here again. Booked a staycation to enjoy the pool, but unfortunately never got the chance because there was no available seating. Most of the chairs were reserved, and the remaining ones were either occupied or being used by day-pass guests. For a hotel that promotes its resort-style ..."

Reviewed on Jul 12, 2026

Blossom Hotel Houston, Curio Collection by Hilton

7118 Bertner Ave Houston TX

Fully refundableReserve now, pay when you stay

$147 nightly

$172 total

Jul 19 - Jul 20

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (3,851 reviews)

"Great hotel! Very luxurious and beautiful— parking is convenient however it is only valet and a hefty price for that."

Reviewed on Jul 12, 2026

Thompson Houston, by Hyatt

1717 ALLEN PARKWAY Houston TX

Fully refundableReserve now, pay when you stay

$249 nightly

$291 total

Jul 26 - Jul 27

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...

9.4/10 Exceptional! (292 reviews)

"The pool area was the best part, and the bartenders"

Reviewed on Jul 9, 2026

The Royal Sonesta Houston Galleria

2222 West Loop South Houston TX

Fully refundableReserve now, pay when you stay

$134 nightly

$157 total

Jul 24 - Jul 25

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...

8.6/10 Excellent! (2,106 reviews)

"This property had issues. Elevators took forever and made so much banging noise; the water in my room would not get hot until maintenance came; the air condition was not steady—air was colder at 77 than it was at 69. This is my last stay at a Sonesta"

Reviewed on Jul 11, 2026

Hilton Houston Plaza/Medical Center

6633 Travis St Houston TX

Fully refundableReserve now, pay when you stay

$100 nightly

$118 total

Jul 25 - Jul 26

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...

8.4/10 Very Good! (2,026 reviews)

"Thank you"

Reviewed on Jul 11, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Texas Medical Center hotel reviews by fellow wanderers

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5

Posted less than an hour ago

Travelocity Verified Review

"The hotel was clean and vey accommodating. Parking can be a little tricky in and out of the hotel but manageable. Male hostess was vey nice and welcoming."

A verified traveler stayed at DoubleTree by Hilton Hotel & Suites Houston by the Galleria