Explore top 2026 4 Star Hotels in Texas Medical Center

Name: Hilton Houston Plaza/Medical Center
Price range: $118 total
Rating: 8.4

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

5701 Main Street Houston TX

Fully refundableReserve now, pay when you stay

$239 nightly

$279 total

Jul 13 - Jul 14

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,016 reviews)

"The room was beautifully cleaned and maintained. The entire lobby and restaurant area is unique and captivating. Food is well prepared and delicious. This was my 6th stay at Zaza in the last few years. I love the transportation service; very friendly and good drivers. Louise Lund 7/5-7/10/26"

Reviewed on Jul 11, 2026

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX

Fully refundableReserve now, pay when you stay

$85 nightly

$99 total

Jul 15 - Jul 16

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (4,339 reviews)

"Quite an underwhelming experience was here for the World Cup and the rooms were not very clean everything was quite dusty."

Reviewed on Jul 11, 2026

Grand Tuscany Hotel

12801 Northwest Fwy Houston TX

Fully refundableReserve now, pay when you stay

$104 nightly

$122 total

Jul 13 - Jul 14

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...

8/10 Very Good! (159 reviews)

"Pool was way too small."

Reviewed on Jul 9, 2026

The Moran CITYCENTRE

800 Sorella Court Houston TX

Fully refundableReserve now, pay when you stay

$204 nightly

$239 total

Jul 19 - Jul 20

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,110 reviews)

"The property is nice. A few things are starting to age and need a little maintenance, but still a very nice place. Only disappointment this time we stayed here was that none of the staff seemed like they wanted to be there. No one was particularly rude, but no one had a smile and every interaction ..."

Reviewed on Jul 11, 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd Houston TX

Fully refundableReserve now, pay when you stay

$123 nightly

$144 total

Jul 31 - Aug 1

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...

8.4/10 Very Good! (4,257 reviews)

"Great hotel, close to everything. We recommend it"

Reviewed on Jul 11, 2026

Marriott Marquis Houston

1777 Walker Street Houston TX

Fully refundableReserve now, pay when you stay

$233 nightly

$272 total

Jul 30 - Jul 31

Total with taxes and fees

A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9/10 Wonderful! (1,165 reviews)

"Loved this hotel. Probably the nicest hotel I have ever stayed at and I am very well traveled. The pool was incredible and everything we imagined, plenty of food options available on site, and staff were very friendly. Would book again in a heartbeat!"

Reviewed on Jul 10, 2026

Blossom Hotel Houston, Curio Collection by Hilton

7118 Bertner Ave Houston TX

Fully refundableReserve now, pay when you stay

$147 nightly

$172 total

Jul 19 - Jul 20

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (3,849 reviews)

"The rooms were beautiful, booking on Expedia I’m assuming they over booked certain rooms but it was no problem they made my birthday weekend extra special with a room upgrade and meal vouchers, even the valet was commendable thank y'all so much!"

Reviewed on Jul 11, 2026

Thompson Houston, by Hyatt

1717 ALLEN PARKWAY Houston TX

Fully refundableReserve now, pay when you stay

$249 nightly

$291 total

Jul 26 - Jul 27

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...

9.4/10 Exceptional! (292 reviews)

"The pool area was the best part, and the bartenders"

Reviewed on Jul 9, 2026

The Royal Sonesta Houston Galleria

2222 West Loop South Houston TX

Fully refundableReserve now, pay when you stay

$134 nightly

$157 total

Jul 24 - Jul 25

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...

8.6/10 Excellent! (2,105 reviews)

"This property had issues. Elevators took forever and made so much banging noise; the water in my room would not get hot until maintenance came; the air condition was not steady—air was colder at 77 than it was at 69. This is my last stay at a Sonesta"

Reviewed on Jul 11, 2026

Hilton Houston Plaza/Medical Center

6633 Travis St Houston TX

Fully refundableReserve now, pay when you stay

$101 nightly

$118 total

Jul 25 - Jul 26

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...

8.4/10 Very Good! (2,024 reviews)

"Thank you"

Reviewed on Jul 11, 2026

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