Explore top 2026 4 Star Hotels in Texas Medical Center

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $276 total per night from Aug 2 to Aug 3
$276 total
Aug 2 - Aug 3
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,014 reviews)
"Gorgeous view from the balcony! Bed and linens super comfortable. The steam shower was absolutely heavenly, water pressure and temp SOOOOO good!! Room service and food was great, and I loved how helpful the staff was. They brought by ice, water, and a snack without me asking once I had been there ..."

Reviewed on Jul 9, 2026

Opens in a new windowHotel Zaza Houston Museum District
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $120 total per night from Jul 15 to Jul 16
$120 total
Jul 15 - Jul 16
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (4,332 reviews)
"I loved everything about my stay at the Club Quarters hotel. Perfect experience, great staff, great restaurant, great coffee, perfect room, clean, historical building with great atmosphere. I will be back!"

Reviewed on Jul 10, 2026

Opens in a new windowClub Quarters Hotel Downtown, Houston
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $122 total per night from Jul 12 to Jul 13
$122 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...
8/10 Very Good! (158 reviews)
"Pool was way too small."

Reviewed on Jul 9, 2026

Opens in a new windowGrand Tuscany Hotel
The Moran CITYCENTRE

The Moran CITYCENTRE

4 out of 5
800 Sorella Court Houston TX
Fully refundableReserve now, pay when you stay
$204 nightly
The price is $239 total per night from Jul 12 to Jul 13
$239 total
Jul 12 - Jul 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,105 reviews)
"Everything was great!"

Reviewed on Jul 8, 2026

Opens in a new windowThe Moran CITYCENTRE
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $144 total per night from Jul 31 to Aug 1
$144 total
Jul 31 - Aug 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
8.4/10 Very Good! (4,249 reviews)
"location"

Reviewed on Jul 10, 2026

Opens in a new windowDoubleTree by Hilton Hotel & Suites Houston by the Galleria
Marriott Marquis Houston

Marriott Marquis Houston

4 out of 5
1777 Walker Street Houston TX
Fully refundableReserve now, pay when you stay
$215 nightly
The price is $251 total per night from Jul 30 to Jul 31
$251 total
Jul 30 - Jul 31
Total with taxes and fees
A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (1,161 reviews)
"Loved this hotel. Probably the nicest hotel I have ever stayed at and I am very well traveled. The pool was incredible and everything we imagined, plenty of food options available on site, and staff were very friendly. Would book again in a heartbeat!"

Reviewed on Jul 10, 2026

Opens in a new windowMarriott Marquis Houston
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $146 total per night from Aug 9 to Aug 10
$146 total
Aug 9 - Aug 10
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,843 reviews)
"I Always have a good stay here"

Reviewed on Jul 9, 2026

Opens in a new windowBlossom Hotel Houston, Curio Collection by Hilton
Thompson Houston, by Hyatt

Thompson Houston, by Hyatt

4 out of 5
1717 ALLEN PARKWAY Houston TX
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $291 total per night from Jul 26 to Jul 27
$291 total
Jul 26 - Jul 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...
9.4/10 Exceptional! (291 reviews)
"The pool area was the best part, and the bartenders"

Reviewed on Jul 9, 2026

Opens in a new windowThompson Houston, by Hyatt
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $157 total per night from Jul 24 to Jul 25
$157 total
Jul 24 - Jul 25
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
8.6/10 Excellent! (2,098 reviews)
"Excellent"

Reviewed on Jul 10, 2026

Opens in a new windowThe Royal Sonesta Houston Galleria
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Jul 31 to Aug 1
$117 total
Jul 31 - Aug 1
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
8.4/10 Very Good! (2,018 reviews)
"Good"

Reviewed on Jul 9, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
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Recent Texas Medical Center hotel reviews by fellow wanderers

Hyatt House Houston Medical Center

Hyatt House Houston Medical Center

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Always very friendly and accommodating. Superior transportation support to and from hotel. Excellent breakfast"
A verified traveler stayed at Hyatt House Houston Medical Center
Hyatt House Houston Medical Center

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