Explore top 2026 4 Star Hotels in Texas Medical Center

Name: DoubleTree by Hilton Hotel Houston - Greenway Plaza
Price range: $125 total
Rating: 8.4

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

5701 Main Street Houston TX

Fully refundableReserve now, pay when you stay

$285 nightly

$334 total

Mar 15 - Mar 16

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury aparthotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (1,913 reviews)

Rooms were clean, staff was friendly and helpful, fitness room ha a pretty good amount of machines and free weights. The complimentary cookies were delicious!

Reviewed on Mar 3, 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd Houston TX

Fully refundableReserve now, pay when you stay

$118 nightly

$138 total

Mar 29 - Mar 30

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...

8.2/10 Very Good! (3,456 reviews)

Parking awful

Reviewed on Mar 4, 2026

The Royal Sonesta Houston Galleria

2222 West Loop South Houston TX

Fully refundableReserve now, pay when you stay

$154 nightly

$180 total

Mar 27 - Mar 28

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...

8.6/10 Excellent! (1,652 reviews)

Paying $35 to park and then struggling to find a spot is crazy. We had a leak from the shower

Reviewed on Mar 5, 2026

Blossom Hotel Houston, Curio Collection by Hilton

7118 Bertner Ave Houston TX

Fully refundableReserve now, pay when you stay

$177 nightly

$207 total

Apr 4 - Apr 5

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (3,756 reviews)

The Blossom Hotel is absolutely amazing. The staff was friendly, the room was gorgeous and the lobby is beautiful. Every area of the hotel was clean. The breakfast was delicious. I stayed for one night and hated that my stay couldn’t be longer. I will definitely stay at The Blossom when I am in Houston ...

Reviewed on Mar 4, 2026

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX

Fully refundableReserve now, pay when you stay

$118 nightly

$138 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (4,072 reviews)

Clean room. Great location.

Reviewed on Mar 5, 2026

Hilton Houston Plaza/Medical Center

6633 Travis St Houston TX

Fully refundableReserve now, pay when you stay

$100 nightly

$117 total

Mar 29 - Mar 30

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...

8.4/10 Very Good! (1,855 reviews)

None

Reviewed on Mar 3, 2026

The Whitehall Houston

1700 Smith St Houston TX

Fully refundableReserve now, pay when you stay

$143 nightly

$167 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (2,021 reviews)

Nice outdoor area, great staff!

Reviewed on Mar 4, 2026

Hyatt Regency Houston/Galleria

2626 Sage Road Houston TX

Fully refundableReserve now, pay when you stay

$136 nightly

$159 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

9/10 Wonderful! (1,266 reviews)

No complimentary water. You have to be an Elite Hyatt member or a bottle of water is $3. Breakfast, I believe ended at 9:30 am, which is way too early. The toilet was a little loose at the bottom, so it moved. Also, they didn't give me any info, on anything, just a key and a room number. No list ...

Reviewed on Feb 28, 2026

The Westin Galleria Houston

5060 W Alabama St Houston TX

Fully refundableReserve now, pay when you stay

$243 nightly

$284 total

Apr 3 - Apr 4

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

DoubleTree by Hilton Hotel Houston - Greenway Plaza

Houston TX

Fully refundableReserve now, pay when you stay

$107 nightly

$125 total

Apr 4 - Apr 5

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.4/10 Very Good! (1,486 reviews)

No water! Had to check out and into a nearby hotel at 9 am and was late to my meeting. Building parking lot looks like a prison. The rooms and building is outdated. Not ever coming back and suggest you look elsewhere.

Reviewed on Mar 4, 2026

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