Explore top 2026 4 Star Hotels in Texas Medical Center
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Top Texas Medical Center 4 Star hotels
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $276 total per night from Aug 2 to Aug 3
$276 total
Aug 2 - Aug 3
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,021 reviews)
"Great staff and amazing hotel"
Reviewed on Jul 13, 2026
Club Quarters Hotel Downtown, Houston
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Jul 14 to Jul 15
$110 total
Jul 14 - Jul 15
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Grand Tuscany Hotel
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $122 total per night from Jul 19 to Jul 20
$122 total
Jul 19 - Jul 20
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...
8/10 Very Good! (164 reviews)
"Beautiful Place"
Reviewed on Jul 13, 2026
The Moran CITYCENTRE
800 Sorella Court Houston TX
Fully refundableReserve now, pay when you stay
$204 nightly
The price is $239 total per night from Jul 19 to Jul 20
$239 total
Jul 19 - Jul 20
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,113 reviews)
"The pool was wonderful for the entire family."
Reviewed on Jul 13, 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $134 total per night from Aug 1 to Aug 2
$134 total
Aug 1 - Aug 2
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
8.4/10 Very Good! (4,270 reviews)
"."
Reviewed on Jul 13, 2026
Marriott Marquis Houston
1777 Walker Street Houston TX
Fully refundableReserve now, pay when you stay
$233 nightly
The price is $272 total per night from Jul 30 to Jul 31
$272 total
Jul 30 - Jul 31
Total with taxes and fees
A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (1,173 reviews)
"N/a"
Reviewed on Jul 12, 2026
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $172 total per night from Jul 24 to Jul 25
$172 total
Jul 24 - Jul 25
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,861 reviews)
"Amazing stay,will visit again"
Reviewed on Jul 13, 2026
Thompson Houston, by Hyatt
1717 ALLEN PARKWAY Houston TX
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $291 total per night from Aug 2 to Aug 3
$291 total
Aug 2 - Aug 3
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...
9.4/10 Exceptional! (293 reviews)
"The pool area was the best part, and the bartenders"
Reviewed on Jul 9, 2026
The Royal Sonesta Houston Galleria
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $157 total per night from Jul 24 to Jul 25
$157 total
Jul 24 - Jul 25
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
8.6/10 Excellent! (2,109 reviews)
"The property was awesome"
Reviewed on Jul 13, 2026
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $107 total per night from Jul 24 to Jul 25
$107 total
Jul 24 - Jul 25
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
8.4/10 Very Good! (2,031 reviews)
"The hotel was older, but beautifully maintained. The staff was excellent, everyone was very helpful and accommodating. We would definitely stay again if we're in the area."
Reviewed on Jul 12, 2026
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Texas Medical Center hotel reviews by fellow wanderers
Blossom Hotel Houston, Curio Collection by Hilton
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Amazing stay,will visit again"
A verified traveler stayed at Blossom Hotel Houston, Curio Collection by Hilton
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