Explore top 2025 4 Star Hotels in Texas Medical Center
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Top Texas Medical Center 4 Star hotels

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $131 total per night from Dec 27 to Dec 28
$131 total
Dec 27 - Dec 28
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
8.2/10 Very Good! (2,976 reviews)
The room was nice, comfy bed, great views
Reviewed on Nov 24, 2025

The Royal Sonesta Houston Galleria
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $139 total per night from Nov 29 to Nov 30
$139 total
Nov 29 - Nov 30
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
8.4/10 Very Good! (1,403 reviews)
Beautiful hotel, delicious breakfast, and great service. The bathroom was not the best in my hotel room.
Reviewed on Nov 24, 2025

The Westin Galleria Houston
5060 W Alabama St Houston TX
Fully refundableReserve now, pay when you stay
$186 nightly
The price is $218 total per night from Nov 29 to Nov 30
$218 total
Nov 29 - Nov 30
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.8/10 Excellent! (1,008 reviews)
Very convenient
Reviewed on Nov 25, 2025

Club Quarters Hotel Downtown, Houston
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $98 total per night from Nov 29 to Nov 30
$98 total
Nov 29 - Nov 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.4/10 Very Good! (3,907 reviews)
Great location and clean rooms. Always our first choice when we stay in downtown
Reviewed on Nov 23, 2025

Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $146 total per night from Dec 28 to Dec 29
$146 total
Dec 28 - Dec 29
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,598 reviews)
good
Reviewed on Nov 27, 2025

Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$288 nightly
The price is $337 total per night from Dec 4 to Dec 5
$337 total
Dec 4 - Dec 5
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury aparthotel. Traveling on business? Take advantage of the 24-hour business ...
8.8/10 Excellent! (1,825 reviews)
Incredible staff, great service all around, beautiful corner suite
Reviewed on Nov 19, 2025

Magnolia Hotel Houston, A Tribute Portfolio Hotel
1100 Texas St Houston TX
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $141 total per night from Dec 22 to Dec 23
$141 total
Dec 22 - Dec 23
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
9/10 Wonderful! (1,286 reviews)
The hotel decor was amazing most of the staff was great. The young
Reviewed on Nov 25, 2025

Omni Houston Hotel
4 Riverway Houston TX
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $189 total per night from Nov 29 to Nov 30
$189 total
Nov 29 - Nov 30
Total with taxes and fees
A full-service spa, a nightclub, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (1,007 reviews)
The state was good however, the people that checked me in were rude as they cannot find my reservation, and the two ladies that were working argued who is going to help me which I thought was very unprofessional. Also, they charge you for parking however they’re self parking gates were broken, so ...
Reviewed on Nov 23, 2025

DoubleTree by Hilton Hotel Houston - Greenway Plaza
Houston TX
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $128 total per night from Nov 29 to Nov 30
$128 total
Nov 29 - Nov 30
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.2/10 Very Good! (1,361 reviews)
N:
Reviewed on Nov 26, 2025

C. Baldwin, Curio Collection by Hilton
400 Dallas St Houston TX
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $196 total per night from Dec 19 to Dec 20
$196 total
Dec 19 - Dec 20
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. A free area shuttle is offered as well. Valet parking, a 24-hour business center, and a coffee ...
8.4/10 Very Good! (1,006 reviews)
Beautiful hotel, decor was nice and the people were friendly.
Reviewed on Nov 21, 2025
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Recent Texas Medical Center hotel reviews by fellow wanderers

The Westin Houston Medical Center/Museum District
5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Was a great stay! Parking charges excessive "
A verified traveler stayed at The Westin Houston Medical Center/Museum District
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