Explore top 2026 4 Star Hotels in Texas Medical Center

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Jul 10 - Jul 12
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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $279 total per night from Jul 17 to Jul 18
$279 total
Jul 17 - Jul 18
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,008 reviews)
"Love this property and its proximity to the Museum of Fine Art Houston and the Museum District. Restaurant is fair — kind of hit-or-miss on food and service. Nice to have the semi-outdoor patio for a buffer zone when the bar is hopping. Front desk and bell team are terrific."

Reviewed on Jul 6, 2026

Opens in a new windowHotel Zaza Houston Museum District
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Jul 28 to Jul 29
$110 total
Jul 28 - Jul 29
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (4,318 reviews)
"The property is nice but really don't understand why they didn't refresh the room daily, I find this really bad I arrived Tuesday and they went to refresh my room just Friday because i bag them in the front door and then they didn't come back until I ask again please do my room on Sunday morning. ..."

Reviewed on Jul 6, 2026

Opens in a new windowClub Quarters Hotel Downtown, Houston
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $113 total per night from Jul 15 to Jul 16
$113 total
Jul 15 - Jul 16
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...
8/10 Very Good! (153 reviews)
"Cheap owners-No waste basket (only in the bathroom), microwave, or fridge in the room. Long wait for elevator. Definitely not worth $178/night."

Reviewed on Jul 6, 2026

Opens in a new windowGrand Tuscany Hotel
The Moran CITYCENTRE

The Moran CITYCENTRE

4 out of 5
800 Sorella Court Houston TX
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $204 total per night from Jul 12 to Jul 13
$204 total
Jul 12 - Jul 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,097 reviews)
"I travel quite a bit, probably 10 hotels at least a year. I usually give 5 stars to every hotel. This hotel while had the location and the looks of an amazing hotel. Stayed there on America's 250th birthday, they had every flag up around their bar for world cup but NO USA flag... I asked why, the ..."

Reviewed on Jul 6, 2026

Opens in a new windowThe Moran CITYCENTRE
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $149 total per night from Jul 31 to Aug 1
$149 total
Jul 31 - Aug 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
8.4/10 Very Good! (4,235 reviews)
"The room where very clean and staff were very nice and helpful"

Reviewed on Jul 5, 2026

Opens in a new windowDoubleTree by Hilton Hotel & Suites Houston by the Galleria
Marriott Marquis Houston

Marriott Marquis Houston

4 out of 5
1777 Walker Street Houston TX
Fully refundableReserve now, pay when you stay
$223 nightly
The price is $261 total per night from Jul 30 to Jul 31
$261 total
Jul 30 - Jul 31
Total with taxes and fees
A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (1,150 reviews)
"Everything about our stay was great. Our room was ready an hour before check in, parking was convenient, room was clean and very nice, pool was amazing. 10/10 would book here again."

Reviewed on Jul 6, 2026

Opens in a new windowMarriott Marquis Houston
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$146 nightly
The price is $170 total per night from Aug 7 to Aug 8
$170 total
Aug 7 - Aug 8
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,828 reviews)
"Very clean and modren!"

Reviewed on Jul 6, 2026

Opens in a new windowBlossom Hotel Houston, Curio Collection by Hilton
Thompson Houston, by Hyatt

Thompson Houston, by Hyatt

4 out of 5
1717 ALLEN PARKWAY Houston TX
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $291 total per night from Jul 26 to Jul 27
$291 total
Jul 26 - Jul 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...
9.4/10 Exceptional! (290 reviews)
"Fantastic"

Reviewed on Jun 28, 2026

Opens in a new windowThompson Houston, by Hyatt
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $157 total per night from Jul 24 to Jul 25
$157 total
Jul 24 - Jul 25
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
8.6/10 Excellent! (2,086 reviews)
"The staff was very helpful."

Reviewed on Jul 6, 2026

Opens in a new windowThe Royal Sonesta Houston Galleria
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $93 total per night from Jul 18 to Jul 19
$93 total
Jul 18 - Jul 19
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Opens in a new windowHilton Houston Plaza/Medical Center
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Recent Texas Medical Center hotel reviews by fellow wanderers

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
Posted 2 hours ago
Travelocity Verified Review
"The property is nice but really don't understand why they didn't refresh the room daily, I find this really bad I arrived Tuesday and they went to refresh my room just Friday because i bag them in the front door and then they didn't come back until I ask again please do my room on Sunday morning. I think this is something do with service and for me this is a bad service"
A verified traveler stayed at Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston

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