Explore top 2026 4 Star Hotels in Texas Medical Center

Name: Hilton Houston Plaza/Medical Center
Price range: $93 total
Rating: 8.4

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

5701 Main Street Houston TX

Fully refundableReserve now, pay when you stay

$241 nightly

$282 total

Jul 7 - Jul 8

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,005 reviews)

"The staff were very helpful and kind. The room was very unique and clean. The bed was perfect."

Reviewed on Jul 5, 2026

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX

Fully refundableReserve now, pay when you stay

$94 nightly

$110 total

Jul 15 - Jul 16

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (4,311 reviews)

"Thanks to you, I had a good time."

Reviewed on Jul 5, 2026

Grand Tuscany Hotel

12801 Northwest Fwy Houston TX

Fully refundableReserve now, pay when you stay

$107 nightly

$125 total

Jul 13 - Jul 14

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...

8/10 Very Good! (149 reviews)

"Good bar. Pool and room not too clean."

Reviewed on Jul 5, 2026

The Moran CITYCENTRE

800 Sorella Court Houston TX

Fully refundableReserve now, pay when you stay

$182 nightly

$213 total

Jul 24 - Jul 25

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,092 reviews)

"Great property with many good restaurants within 1-5 minutes walking distance"

Reviewed on Jul 6, 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd Houston TX

Fully refundableReserve now, pay when you stay

$126 nightly

$148 total

Jul 31 - Aug 1

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...

8.4/10 Very Good! (4,234 reviews)

"The room where very clean and staff were very nice and helpful"

Reviewed on Jul 5, 2026

Marriott Marquis Houston

1777 Walker Street Houston TX

Fully refundableReserve now, pay when you stay

$223 nightly

$261 total

Jul 30 - Jul 31

Total with taxes and fees

A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9/10 Wonderful! (1,148 reviews)

"Excellent hotel, awesome rooftop pool, great vibe"

Reviewed on Jul 6, 2026

Blossom Hotel Houston, Curio Collection by Hilton

7118 Bertner Ave Houston TX

Fully refundableReserve now, pay when you stay

$147 nightly

$172 total

Jul 12 - Jul 13

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (3,824 reviews)

"We stayed for the world cup game, morocco against Canada , big up to the staff! We has wonderful stay"

Reviewed on Jul 6, 2026

Thompson Houston, by Hyatt

1717 ALLEN PARKWAY Houston TX

Fully refundableReserve now, pay when you stay

$249 nightly

$291 total

Jul 19 - Jul 20

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...

9.4/10 Exceptional! (290 reviews)

"Fantastic"

Reviewed on Jun 28, 2026

The Royal Sonesta Houston Galleria

2222 West Loop South Houston TX

Fully refundableReserve now, pay when you stay

$134 nightly

$157 total

Jul 24 - Jul 25

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...

8.6/10 Excellent! (2,083 reviews)

"The room was clean. Staff was helpful. Wonderful stay"

Reviewed on Jul 6, 2026

Hilton Houston Plaza/Medical Center

6633 Travis St Houston TX

Fully refundableReserve now, pay when you stay

$79 nightly

$93 total

Jul 18 - Jul 19

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...

8.4/10 Very Good! (2,004 reviews)

"Honestly it wasn’t what I thought it would be by being located in the hospital district I thought it would of been more cleaner the bath tub was also stopped up to where things like the hair residue from prior guest began to float because the water wasn’t draining out of the tub properly we called ..."

Reviewed on Jul 6, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.