Explore top 2026 4 Star Hotels in Texas Medical Center

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Jul 10 - Jul 12
Next weekend
Jul 17 - Jul 19

Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $279 total per night from Jul 17 to Jul 18
$279 total
Jul 17 - Jul 18
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,006 reviews)
"Clean room great service"

Reviewed on Jul 6, 2026

Opens in a new windowHotel Zaza Houston Museum District
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $110 total per night from Jul 13 to Jul 14
$110 total
Jul 13 - Jul 14
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (4,315 reviews)
"I didn’t like the hotel, it’s outdated."

Reviewed on Jul 6, 2026

Opens in a new windowClub Quarters Hotel Downtown, Houston
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $125 total per night from Jul 13 to Jul 14
$125 total
Jul 13 - Jul 14
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...
8/10 Very Good! (151 reviews)
"Cheap owners-No waste basket (only in the bathroom), microwave, or fridge in the room. Long wait for elevator. Definitely not worth $178/night."

Reviewed on Jul 6, 2026

Opens in a new windowGrand Tuscany Hotel
The Moran CITYCENTRE

The Moran CITYCENTRE

4 out of 5
800 Sorella Court Houston TX
Fully refundableReserve now, pay when you stay
$174 nightly
The price is $204 total per night from Jul 12 to Jul 13
$204 total
Jul 12 - Jul 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,094 reviews)
"Everything was very nice clean staff was excellent. The only complaint was the bed and pillows way too soft."

Reviewed on Jul 6, 2026

Opens in a new windowThe Moran CITYCENTRE
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $149 total per night from Jul 31 to Aug 1
$149 total
Jul 31 - Aug 1
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
8.4/10 Very Good! (4,234 reviews)
"The room where very clean and staff were very nice and helpful"

Reviewed on Jul 5, 2026

Opens in a new windowDoubleTree by Hilton Hotel & Suites Houston by the Galleria
Marriott Marquis Houston

Marriott Marquis Houston

4 out of 5
1777 Walker Street Houston TX
Fully refundableReserve now, pay when you stay
$223 nightly
The price is $261 total per night from Jul 30 to Jul 31
$261 total
Jul 30 - Jul 31
Total with taxes and fees
A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9/10 Wonderful! (1,149 reviews)
"Everyone at the hotel was so nice!"

Reviewed on Jul 6, 2026

Opens in a new windowMarriott Marquis Houston
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $172 total per night from Jul 17 to Jul 18
$172 total
Jul 17 - Jul 18
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,826 reviews)
"I truly enjoyed myself at this hotel. I love the complementary shuttle to nearby locations. It was appreciated. The staff were very nice. The valet guys were on their jobs with wonderful escort service. I felt very special. Definitely my go to hotel whenever I am in Houston!"

Reviewed on Jul 6, 2026

Opens in a new windowBlossom Hotel Houston, Curio Collection by Hilton
Thompson Houston, by Hyatt

Thompson Houston, by Hyatt

4 out of 5
1717 ALLEN PARKWAY Houston TX
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $291 total per night from Jul 26 to Jul 27
$291 total
Jul 26 - Jul 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...
9.4/10 Exceptional! (290 reviews)
"Fantastic"

Reviewed on Jun 28, 2026

Opens in a new windowThompson Houston, by Hyatt
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $157 total per night from Jul 24 to Jul 25
$157 total
Jul 24 - Jul 25
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
8.6/10 Excellent! (2,085 reviews)
"The staff was very helpful."

Reviewed on Jul 6, 2026

Opens in a new windowThe Royal Sonesta Houston Galleria
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $93 total per night from Jul 18 to Jul 19
$93 total
Jul 18 - Jul 19
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Opens in a new windowHilton Houston Plaza/Medical Center
Don't see what you're looking for?
See all available properties in Texas Medical Center
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Texas Medical Center hotel reviews by fellow wanderers

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"I truly enjoyed myself at this hotel. I love the complementary shuttle to nearby locations. It was appreciated. The staff were very nice. The valet guys were on their jobs with wonderful escort service. I felt very special. Definitely my go to hotel whenever I am in Houston!"
A verified traveler stayed at Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by Hilton

Explore More Ways to Travel with Travelocity