Explore top 2026 4 Star Hotels in Texas Medical Center

Name: Hilton Houston Plaza/Medical Center
Price range: $116 total
Rating: 8.4

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

5701 Main Street Houston TX

Fully refundableReserve now, pay when you stay

$236 nightly

$276 total

Jul 25 - Jul 26

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,022 reviews)

"Nice hotel with most staff being helpful . Pool quite small with areas around it restricted unless you’ve booked it apparently with no clear markers . Restaurant on site so it’s a pity breakfast isn’t included Gym was well appointed and quite a size My disappointment came when we checked out to be ..."

Reviewed on Jul 13, 2026

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX

Fully refundableReserve now, pay when you stay

$85 nightly

$99 total

Aug 7 - Aug 8

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

Grand Tuscany Hotel

12801 Northwest Fwy Houston TX

Fully refundableReserve now, pay when you stay

$104 nightly

$122 total

Jul 19 - Jul 20

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...

8/10 Very Good! (169 reviews)

"Beautiful hotel. Good amenities. If breakfast was complimentary this would be a 5-star easily! Will definitely book again."

Reviewed on Jul 14, 2026

The Moran CITYCENTRE

800 Sorella Court Houston TX

Fully refundableReserve now, pay when you stay

$188 nightly

$220 total

Jul 19 - Jul 20

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,116 reviews)

"Our go to Houston hotel"

Reviewed on Jul 14, 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd Houston TX

Fully refundableReserve now, pay when you stay

$115 nightly

$134 total

Jul 31 - Aug 1

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...

8.4/10 Very Good! (4,279 reviews)

"As a woman solo traveler I felt very safe!"

Reviewed on Jul 14, 2026

Marriott Marquis Houston

1777 Walker Street Houston TX

Fully refundableReserve now, pay when you stay

$233 nightly

$272 total

Jul 30 - Jul 31

Total with taxes and fees

A full-service spa, 4 restaurants, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9/10 Wonderful! (1,174 reviews)

"Amazing hotel Stayed here after getting married and they couldn’t have been more accommodating."

Reviewed on Jul 14, 2026

Blossom Hotel Houston, Curio Collection by Hilton

7118 Bertner Ave Houston TX

Fully refundableReserve now, pay when you stay

$139 nightly

$162 total

Aug 14 - Aug 15

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (3,862 reviews)

"Very nice property, upscale and clean with a pool and a bar. The rooms are pretty and spacious and the rooftop pool is very nice. The bar is great too and the bartender Jordan was so welcoming and made awesome drinks! I would def stay there again, I just wish the restaurant opened later because apart ..."

Reviewed on Jul 13, 2026

Thompson Houston, by Hyatt

1717 ALLEN PARKWAY Houston TX

Fully refundableReserve now, pay when you stay

$249 nightly

$291 total

Aug 2 - Aug 3

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this Art Deco hotel. Enjoy the outdoor pool and perks like free WiFi and a free area ...

9.4/10 Exceptional! (294 reviews)

"I really enjoyed the overnight stay. The location was very convenient, and the on-site restaurant made our stay even better. Be sure to ask for Sierra at the Chardon on-site restaurant; she provided excellent customer service."

Reviewed on Jul 13, 2026

The Royal Sonesta Houston Galleria

2222 West Loop South Houston TX

Fully refundableReserve now, pay when you stay

$134 nightly

$157 total

Jul 24 - Jul 25

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...

8.6/10 Excellent! (2,117 reviews)

"Clean room, helpful staff & nice bar"

Reviewed on Jul 14, 2026

Hilton Houston Plaza/Medical Center

6633 Travis St Houston TX

Fully refundableReserve now, pay when you stay

$99 nightly

$116 total

Jul 25 - Jul 26

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...

8.4/10 Very Good! (2,038 reviews)

Reviewed on Jul 14, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Texas Medical Center hotel reviews by fellow wanderers

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5 out of 5

Posted less than an hour ago

Travelocity Verified Review

"As a woman solo traveler I felt very safe!"

A verified traveler stayed at DoubleTree by Hilton Hotel & Suites Houston by the Galleria

Hilton Houston Plaza/Medical Center

5 out of 5

Posted 5 hours ago

Travelocity Verified Review

"I usually don’t leave reviews, but I had to leave one. I just went to Houston for the Dreamcon convention and the next time I come back for next year, I will be also staying at this hotel! The staff are extremely nice and friendly. The rooms are spacious, and the beds are very comfortable! There’s also a Starbucks inside! I will be coming back to this hotel every year for future conventions or just a day trip to Houston! Highly recommend!"

A verified traveler stayed at Hilton Houston Plaza/Medical Center

Hyatt Place Houston Medical Center

4 out of 5

Posted 6 hours ago

Travelocity Verified Review

"My chief complaint is the sickeningly sweet smell of the room. It permeates all my clothes and luggage, and I continue to smell it on my clothes after I get home. Too many hotels do this, and I don't know why. I thought Hyatt Place would be better than this. The other thing that was bizarre was that there were several lights in the room that had no on/off switch. We searched in vain for a way to turn them on, but to no avail. Fortunately, there were a few lamps in the room that we could turn on. Then, on the morning of our departure, with daylight streaming into the room, I found a curious little beige box attached to the wall near the door. It was about the size of a deck of cards, but much thinner. I was able to read the very small print on it by bending over and squinting my eyes. It said that you could get "power" by putting your "card key" in its slot, which I did. And lo and behold, several lights in the room came on. How strange. How absolutely bizarre. Has the Hyatt corporation ever heard of light switches? I can only guess that the management does not want people without "card keys" turning on the lights in your room. But then, why would people without "card keys" be in my room??? But since we were checking out at that point, this newly acquired technical knowledge was of no use to us, and we used the room for an overnight stay without the use of half the lighting in the room."

A verified traveler stayed at Hyatt Place Houston Medical Center

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