Explore top 2026 4 Star Hotels in Brentwood

Name: Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Price range: $145 total
Rating: 8.8

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Top Brentwood 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$127 nightly

$149 total

May 25 - May 26

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,046 reviews)

Everything wonderful.. so close to everything.. easy walking distance and the food was delicious any restaurant in the Hyatt

Reviewed on May 4, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

May 31 - Jun 1

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,817 reviews)

All the restaurants and bar were excellent.

Reviewed on May 4, 2026

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$189 total

May 7 - May 8

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (1,176 reviews)

Clean and comfortable and great location

Reviewed on May 3, 2026

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$136 nightly

$158 total

May 10 - May 11

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.6/10 Excellent! (1,003 reviews)

Valet parking was easy but $50 daily. However very great experience and walk across the street to baseball park. Very friendly staff

Reviewed on May 4, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$172 nightly

$203 total

May 10 - May 11

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9/10 Wonderful! (1,010 reviews)

This was a weekend staycation for my wife and I and as usual we were not disappointed. Very helpful staff and excellent accommodations.

Reviewed on May 4, 2026

The Cheshire

6300 Clayton Rd Richmond Heights MO

$153 nightly

$182 total

May 10 - May 11

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

8.8/10 Excellent! (1,005 reviews)

Breakfast = outstanding! Staff= very friendly and helpful. Room was clean and huge but a bit worn There was a smell of garbage near 2nd floor elevator on May 2…only real negative. I love the decor and theme. Parking garage very roomy & convenient

Reviewed on May 2, 2026

Le Méridien St. Louis Clayton

7730 Bonhomme Ave St. Louis MO

Fully refundableReserve now, pay when you stay

$144 nightly

$169 total

May 10 - May 11

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (712 reviews)

It was good but there is just one problem of parking and they charge for patking 35 bucks

Reviewed on Apr 28, 2026

DoubleTree by Hilton St. Louis Forest Park

4550 Forest Park Ave St. Louis MO

Fully refundableReserve now, pay when you stay

$139 nightly

$163 total

May 21 - May 22

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...

8.2/10 Very Good! (1,002 reviews)

Broken drywall on bathroom floor, old candy bar wrapper in nightstand drawer. Left an item behind and no one would call back. Asked for a cab was told it takes 5 minutes, oh no I was late for an extremely important appointment.

Reviewed on May 2, 2026

River City Casino & Hotel

777 River City Casino Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$112 nightly

$130 total

May 10 - May 11

Total with taxes and fees

This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...

9/10 Wonderful! (1,539 reviews)

The carpet, furniture, and curtains in the room are very outdated and in need of replacement. Upon entering, we were concerned about the cleanliness of the bed; however, the sheets were very clean, and the mattress was comfortable, which was a relief. We were told the pillows were brand new, but ...

Reviewed on May 4, 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO

Fully refundableReserve now, pay when you stay

$122 nightly

$145 total

May 24 - May 25

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...

8.8/10 Excellent! (1,262 reviews)

Parking was hectic, along with valet parking. This hotel needs a lot of TLC. The room I stayed in had peeling paint on the ceiling,light bulbs out, and a bathroom drain stopper that wouldn’t come up to be able to drain. I contacted the front desk about the drain stopper not working and was told that ...

Reviewed on May 4, 2026

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4 Star Hotels Brentwood

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Brentwood 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Brentwood will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Brentwood, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Brentwood hotel reviews by fellow wanderers

Clayton Plaza Hotel & Extended Stay

4 out of 5

Posted 1 hour ago

Travelocity Verified Review

"The front desk staff should better explain which elevator to take to reach the guest room."

A verified traveler stayed at Clayton Plaza Hotel & Extended Stay

Embassy Suites by Hilton St. Louis Downtown

4 out of 5

Posted 2 hours ago

Travelocity Verified Review

"Check-in was at 4pm. We showed up at 5:15pm and the lobby was full of angry guests. Upon checking in, we were told our room was not ready yet due to housekeeping delays. We did not get into our room until 5:50. We had all-inclusive tickets to the Cardinals game and ran about 40 minutes late getting there because the delay at the hotel check-in. Aside from that, staff was nice, room was clean and we enjoyed the stay. Just wish they could've been on time or made attempts to make it right."

A verified traveler stayed at Embassy Suites by Hilton St. Louis Downtown