Explore top 2026 4 Star Hotels in Brentwood

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Next weekend

Top Brentwood 4 Star hotels

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $149 total per night from May 25 to May 26
$149 total
May 25 - May 26
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (4,046 reviews)
Everything wonderful.. so close to everything.. easy walking distance and the food was delicious any restaurant in the Hyatt

Reviewed on May 4, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from May 31 to Jun 1
$173 total
May 31 - Jun 1
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,817 reviews)
All the restaurants and bar were excellent.

Reviewed on May 4, 2026

Opens in a new window21C Museum Hotel St Louis
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $189 total per night from May 7 to May 8
$189 total
May 7 - May 8
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,176 reviews)
Clean and comfortable and great location

Reviewed on May 3, 2026

Opens in a new windowLive by Loews - St.Louis
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $158 total per night from May 10 to May 11
$158 total
May 10 - May 11
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.6/10 Excellent! (1,003 reviews)
Valet parking was easy but $50 daily. However very great experience and walk across the street to baseball park. Very friendly staff

Reviewed on May 4, 2026

Opens in a new windowThe Westin St. Louis
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$172 nightly
The price is $203 total per night from May 10 to May 11
$203 total
May 10 - May 11
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,010 reviews)
This was a weekend staycation for my wife and I and as usual we were not disappointed. Very helpful staff and excellent accommodations.

Reviewed on May 4, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
The Cheshire

The Cheshire

4 out of 5
6300 Clayton Rd Richmond Heights MO
$153 nightly
The price is $182 total per night from May 10 to May 11
$182 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
8.8/10 Excellent! (1,005 reviews)
Breakfast = outstanding! Staff= very friendly and helpful. Room was clean and huge but a bit worn There was a smell of garbage near 2nd floor elevator on May 2…only real negative. I love the decor and theme. Parking garage very roomy & convenient

Reviewed on May 2, 2026

Opens in a new windowThe Cheshire
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $169 total per night from May 10 to May 11
$169 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.8/10 Excellent! (712 reviews)
It was good but there is just one problem of parking and they charge for patking 35 bucks

Reviewed on Apr 28, 2026

Opens in a new windowLe Méridien St. Louis Clayton
DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $163 total per night from May 21 to May 22
$163 total
May 21 - May 22
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.2/10 Very Good! (1,002 reviews)
Broken drywall on bathroom floor, old candy bar wrapper in nightstand drawer. Left an item behind and no one would call back. Asked for a cab was told it takes 5 minutes, oh no I was late for an extremely important appointment.

Reviewed on May 2, 2026

Opens in a new windowDoubleTree by Hilton St. Louis Forest Park
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $130 total per night from May 10 to May 11
$130 total
May 10 - May 11
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,539 reviews)
The carpet, furniture, and curtains in the room are very outdated and in need of replacement. Upon entering, we were concerned about the cleanliness of the bed; however, the sheets were very clean, and the mattress was comfortable, which was a relief. We were told the pillows were brand new, but ...

Reviewed on May 4, 2026

Opens in a new windowRiver City Casino & Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $145 total per night from May 24 to May 25
$145 total
May 24 - May 25
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,262 reviews)
Parking was hectic, along with valet parking. This hotel needs a lot of TLC. The room I stayed in had peeling paint on the ceiling,light bulbs out, and a bathroom drain stopper that wouldn’t come up to be able to drain. I contacted the front desk about the drain stopper not working and was told that ...

Reviewed on May 4, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
Don't see what you're looking for?
See all available properties in Brentwood
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Brentwood

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Brentwood 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Brentwood will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Brentwood, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Brentwood hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity