Explore top 2026 4 Star Hotels in St. Louis

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Top St. Louis 4 Star hotels

21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from May 10 to May 11
$173 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,759 reviews)
I love the history of the hotel. My kids liked the pool and the hot tub was huge. My husband enjoyed the complimentary drink at the bar and tried something new. The art exhibit was neat as well. It was walking distance to everything we needed. Would definitely stay again!

Reviewed on Apr 14, 2026

Opens in a new window21C Museum Hotel St Louis
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $161 total per night from May 8 to May 9
$161 total
May 8 - May 9
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (3,997 reviews)
The staff were excellent. The hotel was magnificent. The location was magical being right next door to the Arch. If looking for breakfast outside of the Hotel, I would recommend Pickles Deli.

Reviewed on Apr 15, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from May 8 to May 9
$143 total
May 8 - May 9
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,086 reviews)
Convenient for the airport

Reviewed on Apr 14, 2026

Opens in a new windowRenaissance St. Louis Airport Hotel
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $130 total per night from Apr 27 to Apr 28
$130 total
Apr 27 - Apr 28
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9/10 Wonderful! (1,523 reviews)
Clean room and courteous staff

Reviewed on Apr 11, 2026

Opens in a new windowRiver City Casino & Hotel
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $174 total per night from May 10 to May 11
$174 total
May 10 - May 11
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.6/10 Excellent! (1,009 reviews)
Great place to stay if your there for a Cardinal game clean rooms adequate parking great breakfast friendly Staff. What's not to like? Would stay again

Reviewed on Apr 15, 2026

Opens in a new windowThe Westin St. Louis
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $189 total per night from Apr 19 to Apr 20
$189 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,155 reviews)
We had a great stay at Live! We stayed Friday—Sunday on a non-game weekend. Our room overlooked the Village and on Friday night there was a DJ and music playing until midnight. This was a very cool room and a fun atmosphere; however we have a young child so it was not ideal for bedtime. Thankfully ...

Reviewed on Apr 14, 2026

Opens in a new windowLive by Loews - St.Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $226 total per night from Apr 26 to Apr 27
$226 total
Apr 26 - Apr 27
Total with taxes and fees
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside ...
8.4/10 Very Good! (1,000 reviews)
Staff was super rude as a frequent traveler we abide by all rules and signs posted when there is no rules or signs posted you treat your guest like trash for not knowing the rules that you never explained in any way.. worst vacation EVER . STAY ANYWHERE ELSE BUT HERE!

Reviewed on Apr 11, 2026

Opens in a new windowAmeristar Casino Resort and Spa
DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
4550 Forest Park Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $163 total per night from May 4 to May 5
$163 total
May 4 - May 5
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.2/10 Very Good! (1,001 reviews)
Clean room.

Reviewed on Apr 14, 2026

Opens in a new windowDoubleTree by Hilton St. Louis Forest Park
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $136 total per night from May 10 to May 11
$136 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.8/10 Excellent! (1,278 reviews)
There is no parking at the hotel.

Reviewed on Apr 13, 2026

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $250 total per night from Apr 26 to Apr 27
$250 total
Apr 26 - Apr 27
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,019 reviews)
Very nice stay. Great staff, nice room.

Reviewed on Apr 14, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
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4 Star Hotels St. Louis

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in St. Louis 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in St. Louis will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in St. Louis, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

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