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21C Museum Hotel St Louis

Property class: 4.5
4.5-star luxury hotel near St. Louis Union Station

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
Exterior
Bar (on property)
Massages

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(105 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(33 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(2 reviews)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About the neighborhood

St. Louis

Heart of St. Louis.Within a 10-minute walk of this Downtown West hotel, you'll find St. Louis Union Station and City Museum. Also, Enterprise Center is within half a mile (1 km) and Busch Stadium is within 2 miles (3 km).

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.1 miles
  • City Museum - 5 min walk - 0.3 miles
  • St. Louis Union Station - 8 min walk - 0.4 miles
  • Enterprise Center - 8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station - 11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

4.5-star luxury hotel near St. Louis Union Station
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness center. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business center and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Meeting rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Similar properties

Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Downtown St. Louis
  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
4.4 out of 5, Excellent, 1,269 reviews
$115 nightly
The price is $136
May 24 - May 25
Total with taxes and fees
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Property amenities

Family friendly

  • Indoor pool
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

Room amenities

Entertainment

  • Flat-screen TV with premium digital channels

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, and American Express. Cash is not accepted. For guests' safety, the property includes a fire extinguisher, a smoke detector, and outdoor lighting in each accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

How close is 21C Museum Hotel St Louis to the airport?

21C Museum Hotel St Louis is 18.4 mi (24-min drive) away from the St. Louis Lambert Intl. Airport (STL) airport, the closest popular airport to the property.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Apr 27, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on May 24, 2026 start from $173, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does 21C Museum Hotel St Louis have an airport shuttle?

Airport shuttle services are not available at 21C Museum Hotel St Louis .

Does 21C Museum Hotel St Louis offer free breakfast?

Free breakfast isn’t provided at 21C Museum Hotel St Louis , but cooked-to-order breakfast is offered for a fee of between USD 10 and 25 per person. It's available every day from 6:30 AM to 1:00 PM.

Is there a casino at 21C Museum Hotel St Louis ?

No, there is no casino at this hotel, but Horseshoe St. Louis Casino (3-min drive) and Casino Queen (5-min drive) are nearby.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM.

Is there free parking at 21C Museum Hotel St Louis ?

Free parking is not available at this hotel. Valet parking is available for USD 50 per day.

Does 21C Museum Hotel St Louis have a pool?

21C Museum Hotel St Louis features an indoor pool.

Does 21C Museum Hotel St Louis have a restaurant?

Yes, there is a restaurant on site.

Does 21C Museum Hotel St Louis have a spa?

This hotel doesn't have a spa, but it does offer massages.

How close is 21C Museum Hotel St Louis to downtown St. Louis?

21C Museum Hotel St Louis is 0.4 mi away from St. Louis.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1265 out of 1791 reviews
Rating 8 - Good. 277 out of 1791 reviews
Rating 6 - Okay. 124 out of 1791 reviews
Rating 4 - Poor. 58 out of 1791 reviews
Rating 2 - Terrible. 67 out of 1791 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.4/10

Property conditions & facilities

Reviews

6/10 Okay

Angela

Traveled with partner
Liked: Cleanliness, property conditions & facilities
Clean room, bar was nice, drinks good. We had to wait 1 hour to check in. It threw off my whole night. We had dinner plans that had to be skipped to get to our event. I was hangry.
Stayed 1 night in Mar 2026

10/10 Excellent

Austin

Stayed 4 nights in Feb 2026

10/10 Excellent

Joel

Stayed 2 nights in Jan 2026

10/10 Excellent

angela

Stayed 3 nights in Jan 2026

10/10 Excellent

Gwendolyn

Stayed 5 nights in Jan 2026

10/10 Excellent

Stacy

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Staff was great!
Stayed 1 night in Jan 2026

6/10 Okay

Seth

Liked: Cleanliness, staff & service, amenities
I really liked the hotel and the staff were very friendly. The room was clean, but the furnace had an issue and the room did not get warmer than 60 degrees. Beautiful place though and despite the issue we will visit again.
Stayed 1 night in Jan 2026

8/10 Good

Michelle

Liked: Cleanliness, staff & service, amenities
The hotel is nice/convenient to concert/sporting events downtown, and their bar is nice; had a bit of a hiccup trying to access their WiFi which needs addressing, but otherwise the property was very nice!
Stayed 1 night in Jan 2026

10/10 Excellent

ANDREA Nicole

Traveled with family
Liked: Cleanliness, staff & service, amenities
Always a wonderful stay! The staff is top notch and the space is perfect for the imaginative mind! Love love love!
Stayed 2 nights in Oct 2025

10/10 Excellent

Zoey

Stayed 1 night in Jan 2026

10/10 Excellent

NICHOLAS, Nashville

Business traveler
Liked: Cleanliness, amenities, property conditions & facilities
Loved the vibe
Stayed 3 nights in Jan 2026

10/10 Excellent

anthony

Stayed 4 nights in Dec 2025

10/10 Excellent

anthony

Liked: Cleanliness, staff & service, amenities
I love the 21C. It’s filled with character and charm. The staff is always super friendly. I stay here once or twice a month for work, never anything but a wonderful stay.
Stayed 4 nights in Jan 2026

8/10 Good

Kate

Stayed 2 nights in Jan 2026

10/10 Excellent

Mary

Stayed 5 nights in Jan 2026

10/10 Excellent

David

Stayed 1 night in Jan 2026

10/10 Excellent

Samantha

Liked: Cleanliness, staff & service, amenities
Room was clean and staff was very informative. Top tier customer service
Stayed 1 night in Jan 2026

8/10 Good

Kate

Traveled with group
Liked: Cleanliness, amenities, property conditions & facilities
Great staff, cool amenities, amazing environment. We had a lot of fun with the penguins! ;)
Stayed 2 nights in Jan 2026

2/10 Terrible

John

Traveled with family
Liked: Cleanliness, property conditions & facilities, room comfort
Not sure what was up with the 2 who checked us in. The Asian guy was mid ok the black guy who processed everything was your worst employee we’ve had at any location. A front desk guy the next morning, 30’s black man, was beyond great and made up for the guy who did check in. Your bartenders are pretentious hipsters who need to learn basic customer service and how to run a bar efficiently. I’ve been a bartender for over 3 decades. They are jerks. Especially the women with the tattoos. Food was below ave. Paella was jard and al debts. Toast with gambas was charred black, not just in ends. I made a comment about it and got brushed off with a laugh. Valet is atrocious. I’ve never seen valet run like this. They don’t come to you and they don’t do any thing with a sense of urgency as you stand in 20 degree weather. It was odd. There were some great team members. Housekeeping was excellent. Meg, manager at restaurant was incredible. Friendly host stand. Good PM restaurant manager, who was friendly. The gym is incredible. Excellent facility. Too bad check in guy did not mention one word about hours or how to use it. Zero hotel overview. He was definitely not having a good day. I think he was annoyed with my dog who is more well behaved then him. Did not look at my note regarding that she is a certified service animal and the purpose for her requirements to travel with me. Room service was slow and hot food was below Luke warm. The art installation is the best I’ve seen At any 21c
Stayed 1 night in Jan 2026

10/10 Excellent

Dimitre

Traveled with group
Liked: Cleanliness, amenities, property conditions & facilities
Great hotel! Art, food and drinks were fantastic
Stayed 1 night in Jan 2026

6/10 Okay

Jolee

Traveled with group
Will not be staying here again. Room was below expectations for the price and not very clean. Restaurant and room service never answered the phone. Valet service was very kind and timely, gym and sauna were dirty, we stayed two nights and had to go to the lobby to get more toilet paper and clean towels after the calling the front desk for them they told us they didn’t have time.
Stayed 2 nights in Jan 2026

10/10 Excellent

Lawren

Stayed 1 night in Jan 2026

10/10 Excellent

Juanita

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
The rooms were nice and clean. Staff was friendly.
Stayed 1 night in Jan 2026

10/10 Excellent

Lauren

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jan 2026

8/10 Good

Mikel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great Location, great atmosphere. Drinks and food on the floor level, beautiful artwork is on display.
Stayed 1 night in Jan 2026