Explore top 2026 4 Star Hotels in Lafayette Square

Name: Ameristar Casino Resort and Spa
Price range: $226 total
Rating: 8.6

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Top Lafayette Square 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$141 nightly

$167 total

Jun 12 - Jun 13

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,073 reviews)

"The hotel staff is the friendliest I have ever experienced."

Reviewed on Jun 2, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$135 nightly

$158 total

Jun 28 - Jun 29

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

$156 nightly

$183 total

Jun 14 - Jun 15

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (1,878 reviews)

"Gorgeous, clean, unique, and within walking distance of everything fun! Valets were so helpful and friendly, right off the bat. They set an excellent first impression. The hotel alone provided a fantastic experience with the art exhibit and the main floor entertainment options. The gym area was the ..."

Reviewed on Jun 3, 2026

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$189 total

Jun 21 - Jun 22

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (1,201 reviews)

"Everything was wonderful"

Reviewed on Jun 2, 2026

River City Casino & Hotel

777 River City Casino Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$92 nightly

$107 total

Jun 8 - Jun 9

Total with taxes and fees

This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...

9/10 Wonderful! (1,592 reviews)

"Everything was great"

Reviewed on Jun 2, 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO

Fully refundableReserve now, pay when you stay

$130 nightly

$155 total

Jun 28 - Jun 29

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...

8.8/10 Excellent! (1,287 reviews)

"Great place! Super comfortable"

Reviewed on Jun 2, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$209 nightly

$246 total

Jun 14 - Jun 15

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9/10 Wonderful! (1,006 reviews)

"Very nice all around, staff was very friendly and helpful, the rooms was clean, the hotel was beautiful"

Reviewed on Jun 1, 2026

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO

Fully refundableReserve now, pay when you stay

$135 nightly

$157 total

Jun 21 - Jun 22

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (1,000 reviews)

"Great location for us, all the staff were very helpful and friendly. Breakfast was different to what we are use to in the UK and Europe, but it was still really good, plenty to choose from and our kids loved it. Parking was close to the room, which was great cause we had lots of bags. Definitely ..."

Reviewed on Jun 2, 2026

St. Louis Union Station Hotel, Curio Collection by Hilton

1820 Market Street St. Louis MO

Fully refundableReserve now, pay when you stay

$142 nightly

$169 total

Jun 20 - Jun 21

Total with taxes and fees

This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Fully refundableReserve now, pay when you stay

$193 nightly

$226 total

Jul 1 - Jul 2

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...

8.6/10 Excellent! (1,000 reviews)

"The door on the toilet room is a really tight squeeze and actually stubbed my toe but other than that (oh and I thought there was a microwave but there was not) it was a good stay with a cool view of the river. Will take more advantage of the pool next time. We were there for a wedding this ..."

Reviewed on Jun 1, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.