Explore top 2026 4 Star Hotels in St. Charles

Name: Marriott St. Louis Airport
Price range: $172 total
Rating: 8

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Top St. Charles 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$125 nightly

$148 total

Nov 25 - Nov 26

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,380 reviews)

"Very nice. I’ll be back. Celebrities and everythin"

Reviewed on Oct 25, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9/10 Wonderful! (2,145 reviews)

"My go to hotel now whenever I go to St. Louis"

Reviewed on Oct 26, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$111 nightly

$130 total

Nov 20 - Nov 21

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

$149 nightly

$177 total

Nov 18 - Nov 19

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$139 nightly

$165 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.4/10 Exceptional! (1,354 reviews)

"This was the perfect spot to stay for the weekend. Came up for the Hockey game and wanted a unique experience of downtown STL while also feeling safe. The staff is extremely welcoming and the overall feel is not overwhelming, it’s super clean, and being right next Busch Ballpark is awesome with great ..."

Reviewed on Oct 25, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Fully refundableReserve now, pay when you stay

$161 nightly

$188 total

Nov 24 - Nov 25

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...

8.6/10 Excellent! (1,083 reviews)

"Property was very nice. Rooms were big and clean. If you don't like smoke avoid the 1st floor of casino it has smoking allowed, but you can go to 2nd floor for smoke free gaming. Overall it was a nice place and I would stay there again."

Reviewed on Oct 25, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$188 total

Nov 22 - Nov 23

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9.2/10 Wonderful! (1,007 reviews)

"The staff was really helpful the morning my daughter was getting married with bringing up extra chairs and helping with validating parking for the hair and makeup people."

Reviewed on Oct 25, 2026

Le Méridien St. Louis Clayton

7730 Bonhomme Ave St. Louis MO

Fully refundableReserve now, pay when you stay

$152 nightly

$179 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$131 nightly

$153 total

Nov 15 - Nov 16

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

8.6/10 Excellent! (1,006 reviews)

"Perfect location. Hotel staff were very welcoming and friendly. Our room was very spacious with a really nice bathroom. Our bed was very comfortable."

Reviewed on Oct 26, 2026

Marriott St. Louis Airport

10700 Pear Tree Lane St. Louis MO

Fully refundableReserve now, pay when you stay

$143 nightly

$172 total

Nov 13 - Nov 14

Total with taxes and fees

This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center, express check-in, and free airport ...

8/10 Very Good! (1,002 reviews)

"Good food an"

Reviewed on Oct 24, 2026

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4 Star Hotels St. Charles

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in St. Charles 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in St. Charles will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in St. Charles, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent St. Charles hotel reviews by fellow wanderers

Pear Tree Inn St. Louis Airport

5 out of 5

Posted less than an hour ago

Travelocity Verified Review

"The front desk staff was very helpful, nice, and friendly. The hotel was quiet, clean, and comfortable. I enjoyed the various happy hour events and the continental breakfast. I’ll definitely book again!"

A verified traveler stayed at Pear Tree Inn St. Louis Airport

Clayton Plaza Hotel & Extended Stay

4 out of 5

Posted 3 hours ago

Travelocity Verified Review

"Even though most of the reviews were great, I was still skeptical because I've had a horrible experience at a highly rated hotel. I must say, the people were telling the truth! The staff was super nice, and the rooms were cleaned. I especially like being able to control the shower temperature digitally. The only downside is that the light in the room is super dim, not great for older eyes. Also, some of the furniture in the room could stand a good deep cleaning. I spray everything down like a mad woman, though. The breakfast buffet was good; however, it never changed in the 3 days I was there, and things like the hash browns and oatmeal were cold. The pool was warm, but could stand a cleaning. Overall, I would stay here again because it was within a 15-minute drive from all of my activities, and as I said, the staff was very nice."

A verified traveler stayed at Clayton Plaza Hotel & Extended Stay