Explore 6 Luxury Hotels in St. Charles

Name: Ameristar Casino Resort and Spa
Price range: $226 total
Rating: 8.4

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Best Luxury Hotels in St. Charles

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

Fully refundable

$131 nightly

$150 total

May 24 - May 25

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. Guests ...

9.4/10 Exceptional! (1,012 reviews)

Perfect location for old St Charles Main St. Clean, well-maintained, and staffed with friendly helpful people. The building is unique with wide hallways, high ceilings, large windows, and lots of character.

Reviewed on Apr 27, 2026

Embassy Suites by Hilton St. Louis St. Charles

2 Convention Center Plz St. Charles MO

Fully refundableReserve now, pay when you stay

$147 nightly

$169 total

May 10 - May 11

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the express check-in and WiFi in public areas. Enjoy ...

8.8/10 Excellent! (1,004 reviews)

The staff there is terrible! Rude and unhelpful.

Reviewed on Apr 27, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Fully refundableReserve now, pay when you stay

$193 nightly

$226 total

Apr 28 - Apr 29

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...

8.4/10 Very Good! (1,005 reviews)

Nice hotel, easy parking, disappointed because of paying resort fees and not using most amenities. But we went mostly for the location of casino. Can’t comment on much else.

Reviewed on Apr 26, 2026

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO

Fully refundable

$61 nightly

$70 total

Apr 28 - Apr 29

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...

6.8/10 (1,003 reviews)

At least there weren't bugs. Fidge was moldy, bedding was stained, bathtub was filthy, half the outside lights flicker right outside the windows. I honestly don't understand how this place has any good reviews

Reviewed on Apr 26, 2026

Red Roof Inn St Louis - St Charles

2010 Zumbehl Road St. Charles MO

Free self parking is available and the hotel's front desk is staffed around-the-clock. Business travelers can take advantage of the business center. A safe deposit ...

5.4/10 (926 reviews)

Hotel was overbooked, was not incormed of this, paid for 3 rooms days ahead of time only to be told nothing was available upon arrival. Called a few hours before check in to confirm everything and was told everything was ready for my check in.

Reviewed on Mar 29, 2021

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in St. Charles

River City Casino & Hotel

777 River City Casino Blvd St. Louis MO

$112 nightly

$130 total

Apr 29 - Apr 30

Total with taxes and fees

9/10 Wonderful! (1,529 reviews)

5 star hotels in St. Charles

Four Seasons Hotel St Louis

999 North Second Street St. Louis MO

$335 nightly

$392 total

May 6 - May 7

Total with taxes and fees

9.4/10 Exceptional! (1,003 reviews)

St. Charles Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the St. Charles luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in St. Charles to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in St. Charles will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in St. Charles, and plan your next opulent escape.

St. Charles hotels essential information

Accommodation	2,382 hotels
Lowest Price	$70
Highest Price	$583
Popular hotels	Ameristar Casino Resort and Spa, Country Inn & Suites by Radisson, St. Charles Historic District, Red Roof Inn St Louis - St Charles, Relax Inn Saint Charles , Embassy Suites by Hilton St. Louis St. Charles

Popular Luxury Stays in St. Charles

Recent St. Charles Hotel Reviews By Fellow Wanderers

Hollywood Casino & Hotel St. Louis

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"Very quite room and professional staff"

A verified traveler stayed at Hollywood Casino & Hotel St. Louis

Hyatt Regency St. Louis at The Arch

3 out of 5

Posted 2 hours ago

Travelocity Verified Review

"When I checked in, I asked & was told there was a complimentary breakfast. When my party went to breakfast the next morning, I was told there was not a comp breakfast and we'd have to purchase. Not even comp. coffee. Very disappointing. "

A verified traveler stayed at Hyatt Regency St. Louis at The Arch

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5

Posted 3 hours ago

Travelocity Verified Review

"Was in room 312 the building seems older attention to detail for cleaning was not there the bedroom walls had hand prints on them with like grease stains of some sort, the bathroom had some type of mold in the shower on the ceiling plus some extra black pubes on it…hair on the floor that wasn’t mine, toilet and sink was clean,You could see random hairs between the white sheets. Doesn’t matter if the building is older you can keep it clean at least. The pool was freezing cold no temperature regulation in it. The elevator floors were really dirty. The beds were comfy. I would not pay $200 to stay here for one night again though. The entire building smelled musty. "

A verified traveler stayed at Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham