Explore 6 Luxury Hotels in St. Charles

Name: Ameristar Casino Resort and Spa
Price range: $215 total
Rating: 8.4

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Best Luxury Hotels in St. Charles

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

Fully refundable

$114 nightly

$131 total

Apr 5 - Apr 6

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. Guests ...

9.4/10 Exceptional! (1,012 reviews)

Good

Reviewed on Mar 6, 2026

Embassy Suites by Hilton St. Louis St. Charles

2 Convention Center Plz St. Charles MO

Fully refundableReserve now, pay when you stay

$118 nightly

$136 total

Mar 15 - Mar 16

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the express check-in and WiFi in public areas. Enjoy ...

8.8/10 Excellent! (1,007 reviews)

Yes everything was perfect.

Reviewed on Mar 6, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Fully refundableReserve now, pay when you stay

$184 nightly

$215 total

Mar 9 - Mar 10

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside ...

8.4/10 Very Good! (1,009 reviews)

At first look it was awesome. However taking a deeper look it becomes terrible. First check in is at 4pm and they close the pool at 6pm. Second the tv did not work making it where you had to order movies if you wanted tv. Then after everything when you sign for the 100 deposit if you do not scroll ...

Reviewed on Mar 4, 2026

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO

Fully refundable

$61 nightly

$71 total

Mar 9 - Mar 10

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are ...

6.8/10 (1,004 reviews)

Cozy and retro

Reviewed on Mar 6, 2026

Red Roof Inn St Louis - St Charles

2010 Zumbehl Road St. Charles MO

Free self parking is available and the hotel's front desk is staffed around-the-clock. Business travelers can take advantage of the business center. A safe deposit ...

5.4/10 (926 reviews)

Hotel was overbooked, was not incormed of this, paid for 3 rooms days ahead of time only to be told nothing was available upon arrival. Called a few hours before check in to confirm everything and was told everything was ready for my check in.

Reviewed on Mar 29, 2021

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in St. Charles

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

$165 nightly

$196 total

Mar 23 - Mar 24

Total with taxes and fees

9/10 Wonderful! (1,925 reviews)

5 star hotels in St. Charles

Four Seasons Hotel St Louis

999 North Second Street St. Louis MO

$325 nightly

$380 total

Mar 12 - Mar 13

Total with taxes and fees

9.4/10 Exceptional! (1,001 reviews)

St. Charles Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the St. Charles luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in St. Charles to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in St. Charles will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in St. Charles, and plan your next opulent escape.

St. Charles hotels essential information

Accommodation	2,360 hotels
Lowest Price	$71
Highest Price	$583
Popular hotels	Ameristar Casino Resort and Spa, Country Inn & Suites by Radisson, St. Charles Historic District, Red Roof Inn St Louis - St Charles, Relax Inn Saint Charles , Embassy Suites by Hilton St. Louis St. Charles

Popular Luxury Stays in St. Charles

Recent St. Charles Hotel Reviews By Fellow Wanderers

Pear Tree Inn St. Louis Near Union Station

4 out of 5

Posted 1 day ago

Travelocity Verified Review

"This was a great value hotel. The rooms were clean the air conditioning worked well, and the room included a free three drink happy hour "

A verified traveler stayed at Pear Tree Inn St. Louis Near Union Station

Clayton Plaza Hotel & Extended Stay

5 out of 5

Posted 3 days ago

Travelocity Verified Review

"I stayed here in 2025 and made sure to return when in town again. The rooms are great, the price is reasonable, and the free breakfast was outstanding. Also, the parking garage is priced reasonably and I saved a lot of money leaving my car at the hotel and taking the light rail downtown."

A verified traveler stayed at Clayton Plaza Hotel & Extended Stay