A brick-paved street lined with historic buildings and a yellow fire hydrant.

Book a hotel near Historic Main Street, St. Charles Historic District

Name: Hollywood Casino & Hotel St. Louis
Price range: $127 total

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Top hotels close to Historic Main Street

Historic Main | 2 Kings + Patio

Saint Charles MO

0.09 mi from Historic Main Street

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This apartment features laundry facilities.

1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

St. Charles MO

0.1 mi from Historic Main Street

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A hot tub is featured at this vacation home, along with a garden and laundry facilities. Barbecue grills are provided for your convenience.

The Foundry Flat | Industrial-Inspired 2-Bedroom

Saint Charles MO

0.11 mi from Historic Main Street

$280 nightly

$309 total

Oct 14 - Oct 15

Total with taxes and fees

Stay at this apartment in St. Charles. Enjoy free WiFi, an in-room coffeemaker, and air conditioning. Popular attractions Ameristar Casino St. Charles and Hollywood Casino Amphitheatre are located nearby.

The Rustic Revival | Charming 2BR Retreat

Saint Charles MO

0.11 mi from Historic Main Street

$296 nightly

$326 total

Oct 12 - Oct 13

Total with taxes and fees

Driftwood Den | Boho 2BR | Dog-Friendly

Saint Charles MO

0.11 mi from Historic Main Street

$290 nightly

$320 total

Oct 12 - Oct 13

Total with taxes and fees

Historic Main Street St. Charles - 2BR

Saint Charles MO

0.11 mi from Historic Main Street

$288 nightly

$318 total

Oct 14 - Oct 15

Total with taxes and fees

Main Street 2BR - Walk to Dining & Riverfront

Saint Charles MO

0.11 mi from Historic Main Street

$304 nightly

$335 total

Oct 11 - Oct 12

Total with taxes and fees

The Global Getaway | World-Inspired 2-Bedroom Stay

Saint Charles MO

0.11 mi from Historic Main Street

$294 nightly

$324 total

Oct 11 - Oct 12

Total with taxes and fees

The St. Charles Guest House, lovely historic home, fun for families and groups

St. Charles MO

0.11 mi from Historic Main Street

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This vacation home features a water park and laundry facilities.

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

0.62 mi from Historic Main Street

$134 nightly

$154 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

0.89 mi from Historic Main Street

$183 nightly

$214 total

Oct 12 - Oct 13

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside bar.

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Free Cancellation

Reserve now, pay when you stay

1.84 mi from Historic Main Street

$108 nightly

$127 total

Nov 1 - Nov 2

Total with taxes and fees

A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, express check-out, and free airport shuttle. Relax with a drink at one of the 3 bars/lounges and enjoy perks like free self parking.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Historic Main Street hotels essential information

Accommodation	513 hotels
Lowest Price	$127
Highest Price	$335
Popular hotels	Ameristar Casino Resort and Spa, The St. Charles Guest House, lovely historic home, fun for families and groups, Country Inn & Suites by Radisson, St. Charles Historic District, Hollywood Casino & Hotel St. Louis, The Foundry Flat \| Industrial-Inspired 2-Bedroom, 1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo., The Rustic Revival \| Charming 2BR Retreat, Historic Main \| 2 Kings + Patio, Driftwood Den \| Boho 2BR \| Dog-Friendly, Historic Main Street St. Charles - 2BR, Main Street 2BR - Walk to Dining & Riverfront, The Global Getaway \| World-Inspired 2-Bedroom Stay