Explore top 2026 5 Star Hotels in Clayton

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Top Clayton 5 Star hotels

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

5 out of 5
999 North Second Street St. Louis MO
Fully refundableReserve now, pay when you stay
$415 nightly
The price is $485 total per night from Jan 1 to Jan 2
$485 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate kid-friendly dining and in-room childcare. ...
9.4/10 Exceptional! (1,000 reviews)
Clean room. Great staff.

Reviewed on Nov 29, 2025

Opens in a new windowFour Seasons Hotel St Louis
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5 out of 5
100 Carondelet Plaza St. Louis MO
Fully refundableReserve now, pay when you stay
$499 nightly
The price is $583 total per night from Dec 21 to Dec 22
$583 total
Dec 21 - Dec 22
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (553 reviews)
Absolutely beautiful hotel!!! Highly recommend!

Reviewed on Nov 28, 2025

Opens in a new windowThe Ritz-Carlton, St. Louis
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Clayton hotel reviews by fellow wanderers

21C Museum Hotel St Louis

21C Museum Hotel St Louis

5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area. "
A verified traveler stayed at 21C Museum Hotel St Louis
21C Museum Hotel St Louis

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