Explore top 2025 5 Star Hotels in Clayton

Name: Four Seasons Hotel St Louis
Price range: $550 total

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Clayton 5 Star hotels

The Ritz-Carlton, St. Louis

100 Carondelet Plaza, St. Louis, MO

Fully refundableReserve now, pay when you stay

$519 nightly

$605 total

Sep 21 - Sep 22

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

Four Seasons Hotel St Louis

999 North Second Street, St. Louis, MO

$470 nightly

$550 total

Sep 25 - Sep 26

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate kid-friendly dining and in-room childcare. ...

Don't see what you're looking for?

See all available properties in Clayton

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.