Explore top 2026 5 Star Hotels in Clayton
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Top Clayton 5 Star hotels

The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
Fully refundableReserve now, pay when you stay
$499 nightly
The price is $583 total per night from Apr 26 to Apr 27
$583 total
Apr 26 - Apr 27
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (565 reviews)
Friendly staff and very clean room.
Reviewed on Apr 15, 2026

Four Seasons Hotel St Louis
999 North Second Street St. Louis MO
Fully refundableReserve now, pay when you stay
$470 nightly
The price is $550 total per night from May 6 to May 7
$550 total
May 6 - May 7
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate kid-friendly dining and in-room childcare. ...
9.4/10 Exceptional! (1,001 reviews)
Food was excellent! Room was clean and wonderful!
Reviewed on Apr 22, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Clayton hotel reviews by fellow wanderers

Pear Tree Inn St. Louis Airport
5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Upon arriving at the property, we were told we were at the wrong property. I didn't realize there were 2. Stephanie proceeded to switch the reservation so we wouldn't have to go across town after driving 8 hours already. I think she was sent from Heaven. We were pleasantly surprised to hear there was a beer/wine welcome in the evening, as well as a nacho bar. While it was appreciated, it consisted of tortilla chips, cheese, jalapeños, salsa, potatoe chips and pretzels. It's quite a large hotel. They also had a decent breakfast in the morning. They are also 2 blocks from Union Station, which was nice. I was quite pleased with the hotel, the room, the staff. I would definitely return if in the area."
A verified traveler stayed at Pear Tree Inn St. Louis Airport
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