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Top hotels in Downtown Clayton

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $180 total per night from May 3 to May 4
$180 total
May 3 - May 4
Total with taxes and fees
2 hot tubs, an indoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in ...
It was super crowded due to spring break, but I think the staff did their best to keep everything refreshed and clean Everyone was professional and kind. We loved the downtown location.

Reviewed on Apr 15, 2026

Opens in a new windowDrury Plaza Hotel St. Louis at the Arch
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5 out of 5
100 Carondelet Plaza St. Louis MO
Fully refundableReserve now, pay when you stay
$499 nightly
The price is $583 total per night from Apr 19 to Apr 20
$583 total
Apr 19 - Apr 20
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
Friendly staff and very clean room.

Reviewed on Apr 15, 2026

Opens in a new windowThe Ritz-Carlton, St. Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Apr 19 to Apr 20
$111 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Terrible outdated hotel

Reviewed on Apr 16, 2026

Opens in a new windowClayton Plaza Hotel & Extended Stay
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $158 total per night from May 10 to May 11
$158 total
May 10 - May 11
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the free WiFi in ...
The room was lovely. The staff was congenial. Well done, AC Clayton.

Reviewed on Apr 14, 2026

Opens in a new windowAC Hotel St. Louis Clayton
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from May 10 to May 11
$173 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Clean room | quick check-in | coffee shop, restaurant and bar inside | small art museum inside | beautiful floral stairwell

Reviewed on Apr 15, 2026

Opens in a new window21C Museum Hotel St Louis
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from May 10 to May 11
$159 total
May 10 - May 11
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Parking went up to $35 night. Small, tight hotel Parking garage, but it was secure. Ice machine in floor Wasn’t working, bar area was nice.

Reviewed on Apr 3, 2026

Opens in a new windowLe Méridien St. Louis Clayton
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $136 total per night from May 3 to May 4
$136 total
May 3 - May 4
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Staff was very friendly and accommodating. Breakfast was a decent spread. Evenings they had beer and nachos available, but the restaurant attached was delicious must try. Also they have a shuttle for cheap that runs to most sporting events so no need to worry about parking or traffic. Overall our ...

Reviewed on Apr 16, 2026

Opens in a new windowPear Tree Inn St. Louis Near Union Station
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $161 total per night from May 8 to May 9
$161 total
May 8 - May 9
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
Good

Reviewed on Apr 16, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $143 total per night from Apr 19 to Apr 20
$143 total
Apr 19 - Apr 20
Total with taxes and fees
A casino, 7 restaurants, and a 24-hour gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
Great stay. Great environment. Great staff.

Reviewed on Apr 15, 2026

Opens in a new windowHollywood Casino & Hotel St. Louis
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Downtown Clayton Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Downtown Clayton area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Downtown Clayton to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Downtown Clayton are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Downtown Clayton hotel reviews by fellow wanderers

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