Find a Hotel in Downtown Clayton

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top hotels in Downtown Clayton

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $179 total per night from Sep 6 to Sep 7
$179 total
Sep 6 - Sep 7
Total with taxes and fees
2 hot tubs, an indoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in ...
"The staff was very friendly and helpful. We really enjoyed the 5:30 kickback (you can make a meal of it) and the breakfast. It is only 3 blocks from Busch Stadium."

Reviewed on Sep 1, 2026

Opens in a new windowDrury Plaza Hotel St. Louis at the Arch
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
$122 nightly
The price is $142 total per night from Sep 6 to Sep 7
$142 total
Sep 6 - Sep 7
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the free WiFi in ...
"Hotel was good and clean."

Reviewed on Sep 1, 2026

Opens in a new windowAC Hotel St. Louis Clayton
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
3550 Samuel Sheppard Drive St. Louis MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $124 total per night from Sep 3 to Sep 4
$124 total
Sep 3 - Sep 4
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...
"Overall, the hotel was very nice. The restaurant and staff super nice. The hotel had a night club upstairs so if that’s your thing this is the spot for you."

Reviewed on Sep 1, 2026

Opens in a new windowAngad Arts Hotel St. Louis, Tapestry Collection by Hilton
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $137 total per night from Sep 6 to Sep 7
$137 total
Sep 6 - Sep 7
Total with taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Everything is amazing! Walking distance to most attractions and secure parking. The restaurant had closed down, however there is a couple places within walking distance. Would stay here again!"

Reviewed on Sep 1, 2026

Opens in a new windowPear Tree Inn St. Louis Near Union Station
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
$134 nightly
The price is $158 total per night from Sep 4 to Sep 5
$158 total
Sep 4 - Sep 5
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
"Nice experience highly recommended"

Reviewed on Sep 1, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $150 total per night from Sep 6 to Sep 7
$150 total
Sep 6 - Sep 7
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
"I recommend this Hotel 10 out of 10 every time I go back home this is where I stay. The staff and the facility. Everything is amazing."

Reviewed on Sep 1, 2026

Opens in a new windowRenaissance St. Louis Airport Hotel
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $94 total per night from Sep 27 to Sep 28
$94 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Opens in a new windowClayton Plaza Hotel & Extended Stay
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $179 total per night from Sep 6 to Sep 7
$179 total
Sep 6 - Sep 7
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Opens in a new windowLe Méridien St. Louis Clayton
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $106 total per night from Sep 7 to Sep 8
$106 total
Sep 7 - Sep 8
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport ...
Opens in a new windowPear Tree Inn St. Louis Airport
Don't see what you're looking for?
See all available properties in Downtown Clayton
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Downtown Clayton Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Downtown Clayton area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Downtown Clayton to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Downtown Clayton are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Downtown Clayton hotel reviews by fellow wanderers

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Nice experience highly recommended"
A verified traveler stayed at Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch

Explore More Ways to Travel with Travelocity