Explore top 2026 4 Star Hotels in Texas Medical Center

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$235 nightly
The price is $274 total per night from Apr 26 to Apr 27
$274 total
Apr 26 - Apr 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9/10 Wonderful! (1,006 reviews)
Hallways a little noisy night. Meeting had hotel meal, which was delish, and served very well by the staff.

Reviewed on Apr 11, 2026

Opens in a new windowHotel Zaza Houston Museum District
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $155 total per night from May 14 to May 15
$155 total
May 14 - May 15
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
8.4/10 Very Good! (3,794 reviews)
Overall rating was ok. The stressfull process was the self park and valet entrance. The hotel did not have a good staff to direct traffic to keep a good traffic flow. Checking into our room was not the best customer service from the front desk with poor attitude and a rushed

Reviewed on Apr 13, 2026

Opens in a new windowDoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $174 total per night from May 8 to May 9
$174 total
May 8 - May 9
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
8.6/10 Excellent! (1,817 reviews)
Clean room , coffee machine didn’t work , when I asked for in house breakfast I was told to call back 30 min later. No biggie. Beautiful property, lovely staff. Will come back if I’m that way again

Reviewed on Apr 12, 2026

Opens in a new windowThe Royal Sonesta Houston Galleria
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $117 total per night from Apr 19 to Apr 20
$117 total
Apr 19 - Apr 20
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
8.4/10 Very Good! (1,882 reviews)
Convenient to hospitals, visiting family at MD Anderson Cancer Center, walkable about 8-10 minutes.

Reviewed on Apr 13, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$158 nightly
The price is $185 total per night from May 14 to May 15
$185 total
May 14 - May 15
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,806 reviews)
Bed was comfortable.

Reviewed on Apr 13, 2026

Opens in a new windowBlossom Hotel Houston, Curio Collection by Hilton
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $167 total per night from Apr 19 to Apr 20
$167 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (2,116 reviews)
Cleaning staff was excellent. Breakfast choices were great. Pool was clean

Reviewed on Apr 13, 2026

Opens in a new windowThe Whitehall Houston
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

4 out of 5
2626 Sage Road Houston TX
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $190 total per night from May 8 to May 9
$190 total
May 8 - May 9
Total with taxes and fees
This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9/10 Wonderful! (1,312 reviews)
Room was clean, front desk clerk was polite and helpful. Food at star bar was excellent

Reviewed on Apr 12, 2026

Opens in a new windowHyatt Regency Houston/Galleria
DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

4 out of 5
Houston TX
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $135 total per night from May 8 to May 9
$135 total
May 8 - May 9
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.4/10 Very Good! (1,551 reviews)
Poor

Reviewed on Apr 13, 2026

Opens in a new windowDoubleTree by Hilton Hotel Houston - Greenway Plaza
Omni Houston Hotel

Omni Houston Hotel

4 out of 5
4 Riverway Houston TX
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $233 total per night from Apr 19 to Apr 20
$233 total
Apr 19 - Apr 20
Total with taxes and fees
A full-service spa, a nightclub, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,006 reviews)
Friendly and clean

Reviewed on Apr 13, 2026

Opens in a new windowOmni Houston Hotel
Houston Marriott Westchase

Houston Marriott Westchase

4 out of 5
2900 Briarpark Dr Houston TX
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $131 total per night from Apr 17 to Apr 18
$131 total
Apr 17 - Apr 18
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
8.4/10 Very Good! (1,013 reviews)
Great experience

Reviewed on Apr 13, 2026

Opens in a new windowHouston Marriott Westchase
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Recent Texas Medical Center hotel reviews by fellow wanderers

Heritage Place Houston Brookhollow

Heritage Place Houston Brookhollow

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"It was good place to stay for a quick trip to Houston with our dog. Easy parking, friendly staff and convenient location. Also, loved that there is a little convenience store. "
A verified traveler stayed at Heritage Place Houston Brookhollow
Heritage Place Houston Brookhollow

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