Explore top 2026 4 Star Hotels in Texas Medical Center

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$228 nightly
The price is $266 total per night from Apr 26 to Apr 27
$266 total
Apr 26 - Apr 27
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9/10 Wonderful! (1,001 reviews)
Great place!

Reviewed on Apr 22, 2026

Opens in a new windowHotel Zaza Houston Museum District
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $147 total per night from May 8 to May 9
$147 total
May 8 - May 9
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...
8.4/10 Very Good! (3,857 reviews)
Room was clean, floor was quiet, staff was courteous & professional and the lobby had a cool vibe. Property conveniently located a couple of blocks from Galleria Mall.

Reviewed on Apr 22, 2026

Opens in a new windowDoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $174 total per night from May 8 to May 9
$174 total
May 8 - May 9
Total with taxes and fees
This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...
8.6/10 Excellent! (1,844 reviews)
.

Reviewed on Apr 22, 2026

Opens in a new windowThe Royal Sonesta Houston Galleria
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
$96 nightly
The price is $112 total per night from Apr 27 to Apr 28
$112 total
Apr 27 - Apr 28
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (4,086 reviews)
Upon entering our room, we discovered that the toilet was backed up and wouldn't flush. It’s never the first thing you want to deal with after a long day of travel, and honestly, my initial reaction was to be pretty annoyed. I called the front desk, and I have to give them credit—they were incredibly ...

Reviewed on Apr 22, 2026

Opens in a new windowClub Quarters Hotel Downtown, Houston
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $119 total per night from May 10 to May 11
$119 total
May 10 - May 11
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...
8.4/10 Very Good! (1,884 reviews)
Room needs fixtures replaced. Towel holder not in good condition and bath tub spigot needs to be worked on. The door security latch is broken and the mattress is way too soft. Staff was very helpful.

Reviewed on Apr 21, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $177 total per night from May 21 to May 22
$177 total
May 21 - May 22
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (3,816 reviews)
Staff friendly, hotel clean, quiet area. Would book again if in Houston

Reviewed on Apr 22, 2026

Opens in a new windowBlossom Hotel Houston, Curio Collection by Hilton
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $142 total per night from May 10 to May 11
$142 total
May 10 - May 11
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (2,147 reviews)
Rooms where dusty, coffee pots didn't work, Faucet leaked. The hallway smelled musty, I was totally shocked at the $50 dollars a day for parking! That would have cost more the rental car by double! The staff was really good and very polite, no complaints there at all! Food was good but limited. Overall ...

Reviewed on Apr 22, 2026

Opens in a new windowThe Whitehall Houston
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

4 out of 5
2626 Sage Road Houston TX
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $190 total per night from May 8 to May 9
$190 total
May 8 - May 9
Total with taxes and fees
This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.2/10 Wonderful! (1,320 reviews)
Great location and very clean

Reviewed on Apr 20, 2026

Opens in a new windowHyatt Regency Houston/Galleria
DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

4 out of 5
Houston TX
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $121 total per night from May 16 to May 17
$121 total
May 16 - May 17
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.4/10 Very Good! (1,562 reviews)
Breakfast buffet overpriced. Guests should not be charged gor parking

Reviewed on Apr 22, 2026

Opens in a new windowDoubleTree by Hilton Hotel Houston - Greenway Plaza
Omni Houston Hotel

Omni Houston Hotel

4 out of 5
4 Riverway Houston TX
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $213 total per night from May 10 to May 11
$213 total
May 10 - May 11
Total with taxes and fees
A full-service spa, a nightclub, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.2/10 Wonderful! (1,000 reviews)
Clean hotel in a nice, quiet location. Staff were great and attentive. I do wish the room would have had a fridge. Overall it was a good stay.

Reviewed on Apr 19, 2026

Opens in a new windowOmni Houston Hotel
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