Explore top 2026 4 Star Hotels in Texas Medical Center

Name: Omni Houston Hotel
Price range: $207 total
Rating: 9.2

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Top Texas Medical Center 4 Star hotels

Hotel Zaza Houston Museum District

5701 Main Street Houston TX

Fully refundableReserve now, pay when you stay

$246 nightly

$288 total

Jul 6 - Jul 7

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9.2/10 Wonderful! (1,013 reviews)

"Great place to stay"

Reviewed on Jun 7, 2026

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX

Fully refundableReserve now, pay when you stay

$101 nightly

$118 total

Jun 9 - Jun 10

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (4,230 reviews)

Reviewed on Jun 7, 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd Houston TX

Fully refundableReserve now, pay when you stay

$153 nightly

$179 total

Jul 5 - Jul 6

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like a free area shuttle. Valet parking, a business center, ...

8.4/10 Very Good! (4,123 reviews)

"Everything was pretty good. The cookies were my favorite part. Parking is not good/ priced per night. If you have 3/4 ppl together in different cars, take one car."

Reviewed on Jun 6, 2026

The Royal Sonesta Houston Galleria

2222 West Loop South Houston TX

Fully refundableReserve now, pay when you stay

$159 nightly

$186 total

Jun 11 - Jun 12

Total with taxes and fees

This hotel features an outdoor pool, A 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-out, ...

8.6/10 Excellent! (1,991 reviews)

"The service overall was exceptional, the staff was very professional."

Reviewed on Jun 7, 2026

Blossom Hotel Houston, Curio Collection by Hilton

7118 Bertner Ave Houston TX

Fully refundableReserve now, pay when you stay

$158 nightly

$185 total

Jul 9 - Jul 10

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (3,875 reviews)

"Our experience was excellent we were greeted almost immediately upon arrival by the staff. The hotel was very clean. We do plan to stay there again."

Reviewed on Jun 7, 2026

Grand Tuscany Hotel

12801 Northwest Fwy Houston TX

Fully refundableReserve now, pay when you stay

$119 nightly

$139 total

Jun 9 - Jun 10

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the lazy river and picnic area. Enjoy the seasonal outdoor pool and perks ...

7.8/10 Good! (89 reviews)

"Great place"

Reviewed on Jun 4, 2026

DoubleTree by Hilton Hotel Houston - Greenway Plaza

Houston TX

Fully refundableReserve now, pay when you stay

$106 nightly

$124 total

Jul 5 - Jul 6

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...

8.4/10 Very Good! (1,639 reviews)

"They overall stay was great the staff was very helpful and the place was clean. My only complaint would be travel to the parking deck it’s kind of aggravating. I stayed in room 521 and the shower head was a bit messed up but still worked just happens to leak a bit at the top. Loved staying at the ..."

Reviewed on Jun 6, 2026

The Whitehall Houston

1700 Smith St Houston TX

Fully refundableReserve now, pay when you stay

$143 nightly

$167 total

Jul 7 - Jul 8

Total with taxes and fees

This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.6/10 Excellent! (2,236 reviews)

"The hotel was clean and quiet. If it was busier the slow elevators might have been an issue."

Reviewed on Jun 7, 2026

Hilton Houston Plaza/Medical Center

6633 Travis St Houston TX

Fully refundableReserve now, pay when you stay

$100 nightly

$117 total

Jul 5 - Jul 6

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas and free ...

8.4/10 Very Good! (1,956 reviews)

"This is an excellent hotel, great staff, rooms are excellent and close to local Red line tram and eateries in the Medical Center district"

Reviewed on Jun 6, 2026

Omni Houston Hotel

4 Riverway Houston TX

Fully refundableReserve now, pay when you stay

$177 nightly

$207 total

Jun 11 - Jun 12

Total with taxes and fees

A full-service spa, a nightclub, and 2 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.2/10 Wonderful! (1,012 reviews)

"Overall good experience, but the parking is expensive for valet. And self parking requires a hike."

Reviewed on Jun 7, 2026

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Recent Texas Medical Center hotel reviews by fellow wanderers

Hilton Garden Inn Houston Medical Center, TX

4 out of 5

Posted 2 hours ago

Travelocity Verified Review

"The staff was very accommodating and the place was very clean."

A verified traveler stayed at Hilton Garden Inn Houston Medical Center, TX

Club Quarters Hotel Downtown, Houston

1 out of 5

Posted 9 hours ago

Travelocity Verified Review

"We pulled up and there were four men working valet. All four of them just sat there, my husband basically had to walk up to them to ask if they were valet for the location. The bad thing is when we first pulled up we pulled to the valet for the hotel before and they ran out and was so eager to help we quickly regretted not choosing that hotel. The hotel is very dated. We requested a microwave and it stopped working a couple times. The water to the toilet just would run and run until you went to jiggle the handle and there was a beep that went off all night long. It was very high pitched and the only thing we could figure was it had something to do with the air being turned on in the room. I would never stay here again the pictures they put online had to have been Photoshopped."

A verified traveler stayed at Club Quarters Hotel Downtown, Houston