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Top hotels in La Jolla Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$237 nightly
The price is $274 total per night from Apr 5 to Apr 6
$274 total
Apr 5 - Apr 6
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
Pool seating was less than expected during a holiday weekend. Only water fountain refill station was in the gym.

Reviewed on Mar 15, 2026

Opens in a new windowHard Rock Hotel San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $150 total per night from Apr 5 to Apr 6
$150 total
Apr 5 - Apr 6
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Great location. Friendly staff. Clean rooms.

Reviewed on Mar 15, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $274 total per night from Apr 2 to Apr 3
$274 total
Apr 2 - Apr 3
Total with taxes and fees
This hotel features 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Perfect service

Reviewed on Mar 13, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$245 nightly
The price is $281 total per night from Apr 5 to Apr 6
$281 total
Apr 5 - Apr 6
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
Dog track of a hotel. Not sure how this is rated 4 stars. Old run down rooms that smell like mildew, things falling apart, rust, and damaged.

Reviewed on Mar 15, 2026

Opens in a new windowParadise Point Resort & Spa
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $186 total per night from Apr 7 to Apr 8
$186 total
Apr 7 - Apr 8
Total with taxes and fees
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
The hotel was beautiful. The staff was celebrating its 100th year of being around. The building is a cool historic building. Staff very friendly and building very clean. The only thing we don’t like was our thermostat was broken and let turn G the heat on and we were told it was fixed. Other than ...

Reviewed on Mar 15, 2026

Opens in a new windowThe Sofia Hotel
DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

4 out of 5
11915 El Camino Real San Diego CA
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $158 total per night from Mar 22 to Mar 23
$158 total
Mar 22 - Mar 23
Total with taxes and fees
This hotel features an outdoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 9 conference rooms, free WiFi in public areas, ...
Great place to stay. Very clean and well taken care of.

Reviewed on Mar 15, 2026

Opens in a new windowDoubleTree by Hilton San Diego - Del Mar
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $126 total per night from Apr 13 to Apr 14
$126 total
Apr 13 - Apr 14
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi ...
Excellent experience

Reviewed on Mar 15, 2026

Opens in a new windowHandlery Hotel
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $123 total per night from Apr 7 to Apr 8
$123 total
Apr 7 - Apr 8
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub ...
Clean room, plentiful parking-overall I was totally satisfied & would stay again.

Reviewed on Mar 15, 2026

Opens in a new windowDays Inn by Wyndham San Diego Hotel Circle
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Apr 1 to Apr 2
$84 total
Apr 1 - Apr 2
Total with taxes and fees
2 hot tubs, an outdoor pool, and a gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi ...
When checking in on Thursday I asked for a late checkout on Saturday because I work Saturday morning and fly home that afternoon. Checkout was 11am. I get off work at 11am and work 10 minutes from this hotel. The person said to ask the morning of departure. Because I leave for work Saturday morning ...

Reviewed on Mar 14, 2026

Opens in a new windowBest Western Seven Seas
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

La Jolla Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on La Jolla Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near La Jolla Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near La Jolla Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent La Jolla Mesa hotel reviews by fellow wanderers

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Pool seating was less than expected during a holiday weekend. Only water fountain refill station was in the gym. "
A verified traveler stayed at Hard Rock Hotel San Diego
Hard Rock Hotel San Diego

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