Explore top 2026 5 Star Hotels in South San Francisco

Name: Four Seasons Hotel Silicon Valley at East Palo Alto
Price range: $441 total
Rating: 9.4

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Top South San Francisco 5 Star hotels

Fairmont San Francisco

950 Mason Street Atop Nob Hill San Francisco CA

Fully refundableReserve now, pay when you stay

$261 nightly

$307 total

May 25 - May 26

Total with taxes and fees

A full-service spa, 2 restaurants, and a gym are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, express ...

9/10 Wonderful! (1,523 reviews)

Our stay was excellent from day one! Every staff member is great. So friendly, helpful snd attentive. Beautiful room and view. Never had an issue with the room and housekeeping was so prompt. The historical pictures on the walls really tell a story and transport you into the past! We loved our stay. ...

Reviewed on Apr 28, 2026

Claremont Resort & Club

41 Tunnel Road Berkeley CA

Fully refundableReserve now, pay when you stay

$345 nightly

$392 total

May 2 - May 3

Total with taxes and fees

This luxury hotel features 3 restaurants, 3 outdoor pools, and 8 outdoor tennis courts. Bring the family and enjoy the children's club, playground, and kid-friendly ...

9/10 Wonderful! (1,006 reviews)

Enjoyed the pool

Reviewed on Apr 27, 2026

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St San Francisco CA

Fully refundableReserve now, pay when you stay

$327 nightly

$385 total

May 22 - May 23

Total with taxes and fees

This luxury hotel includes 2 restaurants, an indoor pool, and a hot tub. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

9.2/10 Wonderful! (1,000 reviews)

Very beautiful hotel in very nice location, close to everything.

Reviewed on Apr 18, 2026

Taj Campton Place

340 Stockton St San Francisco CA

Fully refundableReserve now, pay when you stay

$244 nightly

$286 total

May 1 - May 2

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9.2/10 Wonderful! (1,002 reviews)

Smallish room but not bad for SF

Reviewed on Apr 23, 2026

Four Seasons Hotel San Francisco at Embarcadero

222 Sansome St San Francisco CA

Fully refundableReserve now, pay when you stay

$436 nightly

$513 total

May 29 - May 30

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Families will appreciate the onsite laundry facilities and in-room childcare. Traveling on ...

9.6/10 Exceptional! (1,005 reviews)

beautiful views, super clean, very attentive staff. the property is super nice, we just believe its missing a cool rooftop bar or breakfast area with those amazing views.

Reviewed on Apr 28, 2026

The Ritz-Carlton, San Francisco

600 Stockton St San Francisco CA

Fully refundableReserve now, pay when you stay

$406 nightly

$477 total

May 8 - May 9

Total with taxes and fees

This luxury hotel features 2 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

9.4/10 Exceptional! (1,002 reviews)

The club staff has become like family

Reviewed on Apr 22, 2026

Four Seasons Hotel San Francisco

757 Market St San Francisco CA

Fully refundableReserve now, pay when you stay

$525 nightly

$618 total

May 1 - May 2

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Families will appreciate kid-friendly dining and in-room childcare. Enjoy ...

9.4/10 Exceptional! (1,002 reviews)

security and front desk is discriminating against my brain injury. I suffer from aggravation of psychological trauma because of coercion and discriminating by security and front desk, general manager

Reviewed on Apr 25, 2026

1 Hotel San Francisco

8 Mission St San Francisco CA

Fully refundable

$397 nightly

$467 total

May 25 - May 26

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the in-room fitness and perks like free WiFi. There's a ...

9.2/10 Wonderful! (537 reviews)

Great ambience, clean and aesthetically pleasing.

Reviewed on Apr 23, 2026

The St. Regis San Francisco

125 3rd St San Francisco CA

Fully refundableReserve now, pay when you stay

$428 nightly

$505 total

May 29 - May 30

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

9.4/10 Exceptional! (722 reviews)

The shower was the best part. Also if you need a bath to unwind they got you covered. Spa, gym, hotter all available

Reviewed on Apr 22, 2026

Four Seasons Hotel Silicon Valley at East Palo Alto

2050 University Ave, East Palo Alto Palo Alto CA

Fully refundableReserve now, pay when you stay

$388 nightly

$441 total

May 22 - May 23

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the express check-in, ...

9.4/10 Exceptional! (680 reviews)

The location is uber convenient, the staff was wonderful, and the rooms are very nice.

Reviewed on Apr 28, 2026

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South San Francisco Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in South San Francisco to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. South San Francisco 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in South San Francisco before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.