Explore top 2026 5 Star Hotels in South San Francisco

Name: The St. Regis San Francisco
Price range: $591 total
Rating: 9.4

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Top South San Francisco 5 Star hotels

Fairmont San Francisco

950 Mason Street Atop Nob Hill San Francisco CA

Fully refundableReserve now, pay when you stay

$300 nightly

$353 total

Aug 30 - Aug 31

Total with taxes and fees

A full-service spa, 2 restaurants, and a gym are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, express ...

9/10 Wonderful! (1,551 reviews)

"Beautiful and clean property. Very comfortable beds."

Reviewed on Aug 2, 2026

Taj Campton Place

340 Stockton St San Francisco CA

Fully refundableReserve now, pay when you stay

$232 nightly

$273 total

Aug 23 - Aug 24

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St San Francisco CA

Fully refundableReserve now, pay when you stay

$345 nightly

$406 total

Aug 14 - Aug 15

Total with taxes and fees

This luxury hotel includes 2 restaurants, an indoor pool, and a hot tub. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

Claremont Resort & Club

41 Tunnel Road Berkeley CA

Fully refundableReserve now, pay when you stay

$310 nightly

$350 total

Aug 9 - Aug 10

Total with taxes and fees

This luxury hotel features 3 restaurants, 3 outdoor pools, and 8 outdoor tennis courts. Bring the family and enjoy the children's club, playground, and kid-friendly ...

9/10 Wonderful! (1,063 reviews)

"Thank you for a nice business trip stay"

Reviewed on Aug 4, 2026

Four Seasons Hotel San Francisco at Embarcadero

222 Sansome St San Francisco CA

Fully refundableReserve now, pay when you stay

$459 nightly

$540 total

Sep 3 - Sep 4

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Families will appreciate the onsite laundry facilities and in-room childcare. Traveling on ...

9.6/10 Exceptional! (1,002 reviews)

"The service was superb"

Reviewed on Aug 4, 2026

The Ritz-Carlton, San Francisco

600 Stockton St San Francisco CA

Fully refundableReserve now, pay when you stay

$386 nightly

$454 total

Aug 16 - Aug 17

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, and valet ...

9.4/10 Exceptional! (1,001 reviews)

"The staff was VERY accommodating!!!!"

Reviewed on Jul 30, 2026

Four Seasons Hotel San Francisco

757 Market St San Francisco CA

Fully refundableReserve now, pay when you stay

$384 nightly

$452 total

Sep 4 - Sep 5

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Families will appreciate kid-friendly dining and in-room childcare. Enjoy ...

1 Hotel San Francisco

8 Mission St San Francisco CA

Fully refundableReserve now, pay when you stay

$397 nightly

$467 total

Sep 4 - Sep 5

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the in-room fitness and perks like free WiFi. There's a ...

9.2/10 Wonderful! (587 reviews)

"Our new favorite hotel in San Francisco. It’s such a beautiful, fresh luxurious hotel. Great location."

Reviewed on Aug 3, 2026

The Huntington Hotel

1075 California St San Francisco CA

Fully refundableReserve now, pay when you stay

$844 nightly

$993 total

Aug 5 - Aug 6

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the free WiFi in public areas, express ...

9.4/10 Exceptional! (28 reviews)

"I have not experienced this level of service in San Francisco anywhere else. The staff was friendly, helpful and went above and beyond to make us feel welcome. From ensuring we had rides, reservations and the necessary infrastructure to conduct work from the hotel to the little touches of dropping ..."

Reviewed on Jul 29, 2026

The St. Regis San Francisco

125 3rd St San Francisco CA

Fully refundableReserve now, pay when you stay

$501 nightly

$591 total

Sep 4 - Sep 5

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

9.4/10 Exceptional! (733 reviews)

"Great place"

Reviewed on Aug 3, 2026

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South San Francisco Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in South San Francisco to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. South San Francisco 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in South San Francisco before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.