Explore top 2025 5 Star Hotels in San Mateo

Name: Four Seasons Hotel Silicon Valley at East Palo Alto
Price range: $546 total

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Top San Mateo 5 Star hotels

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco, CA

Fully refundableReserve now, pay when you stay

$305 nightly

$359 total

Oct 6 - Oct 7

Total with taxes and fees

A full-service spa, 2 restaurants, and a gym are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, express ...

Taj Campton Place

340 Stockton St, San Francisco, CA

$208 nightly

$244 total

Sep 13 - Sep 14

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

Shashi Hotel Mountain View Palo Alto

1625 N Shoreline Blvd, Mountain View, CA

Fully refundableReserve now, pay when you stay

$133 nightly

$147 total

Sep 6 - Sep 7

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco, CA

Fully refundableReserve now, pay when you stay

$319 nightly

$375 total

Sep 6 - Sep 7

Total with taxes and fees

This smoke-free hotel includes 2 restaurants, an indoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

The Ritz-Carlton, San Francisco

600 Stockton St, San Francisco, CA

Fully refundableReserve now, pay when you stay

$435 nightly

$512 total

Oct 5 - Oct 6

Total with taxes and fees

This luxury hotel features 2 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...

Four Seasons Hotel San Francisco

757 Market St, San Francisco, CA

$415 nightly

$488 total

Oct 2 - Oct 3

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this smoke-free hotel. Families will appreciate kid-friendly dining and in-room childcare. Enjoy ...

1 Hotel San Francisco

8 Mission St, San Francisco, CA

$394 nightly

$464 total

Oct 3 - Oct 4

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the in-room fitness and perks like free WiFi. There's a ...

Four Seasons Hotel San Francisco at Embarcadero

222 Sansome St, San Francisco, CA

$455 nightly

$535 total

Sep 26 - Sep 27

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Families will appreciate the onsite laundry facilities and in-room childcare. Traveling on ...

The St. Regis San Francisco

125 3rd St, San Francisco, CA

Fully refundableReserve now, pay when you stay

$481 nightly

$567 total

Oct 4 - Oct 5

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

Four Seasons Hotel Silicon Valley at East Palo Alto

2050 University Ave, East Palo Alto, Palo Alto, CA

Fully refundableReserve now, pay when you stay

$480 nightly

$546 total

Sep 14 - Sep 15

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the express check-in, ...

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San Mateo Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in San Mateo to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. San Mateo 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in San Mateo before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.