Explore top 2026 4 Star Hotels in University City

Name: 21C Museum Hotel St Louis
Price range: $173 total

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Top University City 4 Star hotels

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$179 total

per night

Jul 31 - Aug 1

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,153 reviews)

"Love it, now I will really consider it as one of my favorite"

Reviewed on Jul 20, 2026

Moonrise Hotel

6177 Delmar Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$234 total

per night

Jul 28 - Jul 29

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

9/10 Wonderful! (2,001 reviews)

"Had a separate party on the rooftop...not considering guests would want to enjoy the rooftop. Gotta decide if u want to accommodate guests or host events. Party cleanup was a nuisance all night. Got comped...but still."

Reviewed on Jul 20, 2026

St. Louis Union Station Hotel, Curio Collection by Hilton

1820 Market Street St. Louis MO

Fully refundableReserve now, pay when you stay

$177 total

per night

Aug 17 - Aug 18

This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...

8.8/10 Excellent! (1,004 reviews)

"Great place, will definitely visit again. Everyone was really nice, and I really appreciated that all the restaurants and the aquarium were all within the same complex. So I never had to get into my car. You did go to the arch and the zoo, and those were no more than 6 to 8 minutes away. I would ..."

Reviewed on Jul 20, 2026

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

$234 total

per night

Aug 3 - Aug 4

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$189 total

per night

Aug 3 - Aug 4

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$164 total

per night

Aug 6 - Aug 7

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO

Fully refundableReserve now, pay when you stay

$171 total

per night

Aug 9 - Aug 10

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8.8/10 Excellent! (1,006 reviews)

"Our stay was extremely disappointing. Upon arrival, we were assigned a second-floor villa room with no elevator, requiring us to carry all of our luggage up a flight of stairs. The hallways and stairwell were visibly dirty, creating a poor first impression. When we entered our room, we were immediately ..."

Reviewed on Jul 20, 2026

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$135 total

per night

Aug 7 - Aug 8

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,122 reviews)

"Not many breakfast options"

Reviewed on Jul 20, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$126 total

per night

Aug 3 - Aug 4

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

9/10 Wonderful! (1,085 reviews)

"My husband and I booked this hotel as it seemed to be in a generally busy area and close to a bar that brought us into town for an event they were hosting. Upon arrival we were greeted by the valet who was incredibly kind - we then went upstairs to check in and were greeted by two lovely women who ..."

Reviewed on Jul 20, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$173 total

per night

Aug 9 - Aug 10

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.