Explore top 2026 4 Star Hotels in Clayton

Name: Ameristar Casino Resort and Spa
Price range: $214 total

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Clayton 4 Star hotels

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO

Fully refundableReserve now, pay when you stay

$118 nightly

$138 total

Oct 29 - Oct 30

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,175 reviews)

"I have no complaints about this hotel. The staff was pleasant and helpful. It was wonderfully clean throughout. The Renaissance Hotel has my highest recommendation as a wonderful place to stay."

Reviewed on Oct 4, 2026

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$134 nightly

$158 total

Oct 30 - Oct 31

Total with taxes and fees

This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...

8.6/10 Excellent! (4,343 reviews)

Reviewed on Oct 6, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

$148 nightly

$173 total

Nov 1 - Nov 2

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...

The Cheshire

6300 Clayton Rd Richmond Heights MO

Fully refundableReserve now, pay when you stay

$148 nightly

$176 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

8.8/10 Excellent! (1,007 reviews)

"The front staff was so welcoming and kind. The room so unique"

Reviewed on Oct 5, 2026

Live by Loews - St.Louis

799 Clark ave St. Louis MO

Fully refundableReserve now, pay when you stay

$159 nightly

$189 total

Oct 18 - Oct 19

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

The Westin St. Louis

811 Spruce St St. Louis MO

Fully refundableReserve now, pay when you stay

$131 nightly

$153 total

Oct 18 - Oct 19

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

Fully refundableReserve now, pay when you stay

$186 nightly

$219 total

Nov 1 - Nov 2

Total with taxes and fees

This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...

9.2/10 Wonderful! (1,005 reviews)

"Excellent Hotel in a Perfect Location I had a wonderful stay at The Royal Sonesta Chase Park Plaza St. Louis. The location is excellent, especially if you need to visit Washington University or explore the Central West End. One of the best things about the hotel is that it is right across from Forest ..."

Reviewed on Oct 5, 2026

River City Casino & Hotel

777 River City Casino Blvd St. Louis MO

Fully refundableReserve now, pay when you stay

$110 nightly

$130 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...

9/10 Wonderful! (1,810 reviews)

"Great accommodations - highly recommend"

Reviewed on Oct 6, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

3550 Samuel Sheppard Drive St. Louis MO

Fully refundableReserve now, pay when you stay

$122 nightly

$144 total

Oct 11 - Oct 12

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

$183 nightly

$214 total

Oct 12 - Oct 13

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside ...

Don't see what you're looking for?

See all available properties in Clayton

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Clayton hotel reviews by fellow wanderers

Drury Plaza Hotel St. Louis at the Arch

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"We really enjoyed staying here. The breakfast was delicious each morning. The 5:30 Kickback was a pleasant surprise and was also delicious each evening. It was also nice to be so close to the Arch."

A verified traveler stayed at Drury Plaza Hotel St. Louis at the Arch

Hyatt Regency St. Louis at The Arch

4 out of 5

Posted 1 hour ago

Travelocity Verified Review

"The location is fantastic. I had an amazing view of the Arch directly outside my window, the staff was extremely helpful and friendly, and the bar downstairs was also a great spot. Unfortunately, the hotel itself was disappointing. My room was a nice size, but it felt old, dark, and in serious need of an update. Even with the incredible Arch view, the window had a cloudy white film between the panes AND dead bugs along it, which really took away from the view. Also, NO full-length mirror anywhere! In a room this size, I don't understand how that's possible. I literally had to stand on the toilet to see the bottom half of my outfit in the bathroom mirror. The bathroom itself could also use updating. The water pressure was okay, but the shower head was not great. One other heads-up: guest packages are handled by the FedEx location inside the hotel, which charges $4 PER PACKAGE for pickup. Amazon split my order into two packages, so I unexpectedly paid $8. I definitely would've made other arrangements had I known. Overall, you can't beat the location and the staff was wonderful, but the rooms need some serious TLC to match what I'd expect from a Hyatt Regency."

A verified traveler stayed at Hyatt Regency St. Louis at The Arch