Explore top 2025 4 Star Hotels in Clayton

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Top Clayton 4 Star hotels

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $117 total per night from Nov 23 to Nov 24
$117 total
Nov 23 - Nov 24
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.4/10 Very Good! (3,996 reviews)
Perfect spot! Walking distance to everything downtown STL.

Reviewed on Nov 3, 2025

Opens in a new windowHyatt Regency St. Louis at The Arch
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St, St. Louis, MO
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $104 total per night from Nov 9 to Nov 10
$104 total
Nov 9 - Nov 10
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
8.6/10 Excellent! (1,078 reviews)
The app to pay for the valet was hard to get into.

Reviewed on Oct 31, 2025

Opens in a new windowMagnolia Hotel St. Louis, a Tribute Portfolio Hotel
St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

4 out of 5
1820 Market Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $165 total per night from Nov 23 to Nov 24
$165 total
Nov 23 - Nov 24
Total with taxes and fees
This historic hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free ...
8.4/10 Very Good! (1,037 reviews)
Great

Reviewed on Nov 5, 2025

Opens in a new windowSt. Louis Union Station Hotel, Curio Collection by Hilton
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
3550 Samuel Sheppard Drive, St. Louis, MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $150 total per night from Nov 10 to Nov 11
$150 total
Nov 10 - Nov 11
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, along with free WiFi in public areas. ...
8.8/10 Excellent! (1,011 reviews)
very blue room, very strange decor - in a pleasant way

Reviewed on Nov 1, 2025

Opens in a new windowAngad Arts Hotel St. Louis, Tapestry Collection by Hilton
The Cheshire

The Cheshire

4 out of 5
6300 Clayton Rd, Richmond Heights, MO
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $153 total per night from Nov 23 to Nov 24
$153 total
Nov 23 - Nov 24
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
8.4/10 Very Good! (1,005 reviews)
Everything was wonderful. The breakfast was awesome

Reviewed on Nov 1, 2025

Opens in a new windowThe Cheshire
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street, St. Louis, MO
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $168 total per night from Nov 26 to Nov 27
$168 total
Nov 26 - Nov 27
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,435 reviews)
Loved this hotel. Nice atmosphere

Reviewed on Nov 1, 2025

Opens in a new window21C Museum Hotel St Louis
DoubleTree by Hilton St. Louis Airport

DoubleTree by Hilton St. Louis Airport

4 out of 5
4505 Woodson Road, St. Louis, MO
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $139 total per night from Nov 10 to Nov 11
$139 total
Nov 10 - Nov 11
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Bring the family and enjoy the arcade/game room and kid-friendly dining. There's no skimping ...
7.8/10 Good! (837 reviews)
Everything was great. I’m a frequent and never had issues.

Reviewed on Oct 29, 2025

Opens in a new windowDoubleTree by Hilton St. Louis Airport
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road, St. Louis, MO
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $138 total per night from Nov 21 to Nov 22
$138 total
Nov 21 - Nov 22
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,032 reviews)
Staff was excellent

Reviewed on Oct 26, 2025

Opens in a new windowRenaissance St. Louis Airport Hotel
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $151 total per night from Nov 22 to Nov 23
$151 total
Nov 22 - Nov 23
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8/10 Very Good! (1,016 reviews)
Stay for one day with family and property is good

Reviewed on Oct 25, 2025

Opens in a new windowMarriott St. Louis Grand
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $177 total per night from Nov 20 to Nov 21
$177 total
Nov 20 - Nov 21
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.2/10 Wonderful! (1,066 reviews)
Breakfast was to order, great service!

Reviewed on Nov 2, 2025

Opens in a new windowLive by Loews - St.Louis
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