Explore top 2026 4 Star Hotels in Brentwood

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Top Brentwood 4 Star hotels

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $175 total per night from Jul 17 to Jul 18
$175 total
Jul 17 - Jul 18
Total with taxes and fees
This smoke-free hotel's 3 restaurants, 2 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
8.6/10 Excellent! (4,179 reviews)
"The property was in an excellent location to see many tourists areas. From the valet staff to the bell staff to the check in staff everyone was extremely courteous, helpful and went out of their way to do everything for you. The entire property was well maintained and clean. Our room was clean, well ..."

Reviewed on Jun 30, 2026

Opens in a new windowHyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $153 total per night from Jul 31 to Aug 1
$153 total
Jul 31 - Aug 1
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...
8.4/10 Very Good! (1,107 reviews)
"All Good. Staff good blah blah nlah"

Reviewed on Jun 29, 2026

Opens in a new windowRenaissance St. Louis Airport Hotel
Moonrise Hotel

Moonrise Hotel

4 out of 5
6177 Delmar Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $208 total per night from Jul 1 to Jul 2
$208 total
Jul 1 - Jul 2
Total with taxes and fees
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
9/10 Wonderful! (1,987 reviews)
"The manager Andre along with the rest of the staff was great and helpful. The staff were polite and answered all questions and were respectful and professional."

Reviewed on Jun 30, 2026

Opens in a new windowMoonrise Hotel
The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
212 N Kingshighway St. Louis MO
Fully refundableReserve now, pay when you stay
$192 nightly
The price is $226 total per night from Jul 4 to Jul 5
$226 total
Jul 4 - Jul 5
Total with taxes and fees
This luxury hotel features 3 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and ...
9/10 Wonderful! (1,011 reviews)
"Loved our stay! We had a girls’ weekend and the pool was definitely the highlight of our stay with the good drinks and food!"

Reviewed on Jun 29, 2026

Opens in a new window The Royal Sonesta Chase Park Plaza St. Louis
St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

4 out of 5
1820 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $190 total per night from Jul 17 to Jul 18
$190 total
Jul 17 - Jul 18
Total with taxes and fees
This luxury hotel's 7 restaurants, 3 bars/lounges, and 24-hour gym are some of the featured amenities. Enjoy the seasonal outdoor pool and perks like free WiFi. ...
8.6/10 Excellent! (1,007 reviews)
"The hotel was beautiful and the location was great! Most attractions were walkable or only a short drive away. The rooms were clean and the staff was friendly and helpful."

Reviewed on Jun 29, 2026

Opens in a new windowSt. Louis Union Station Hotel, Curio Collection by Hilton
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $189 total per night from Jul 5 to Jul 6
$189 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...
9.4/10 Exceptional! (1,225 reviews)
"Everything was high quality from the food and drinks to the bedding, and warm friendly staff."

Reviewed on Jun 29, 2026

Opens in a new windowLive by Loews - St.Louis
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

4 out of 5
1335 S Lindbergh Blvd Frontenac MO
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $157 total per night from Jul 5 to Jul 6
$157 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.8/10 Excellent! (1,005 reviews)
"Amazing location and beautiful facility"

Reviewed on Jun 29, 2026

Opens in a new windowHilton St. Louis Frontenac
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
$101 nightly
The price is $118 total per night from Jul 12 to Jul 13
$118 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features a casino, a nightclub, and 5 restaurants. Traveling on business? Take advantage of the business center, conference center, and conference ...
9.2/10 Wonderful! (1,642 reviews)
"We very much enjoyed out stay. The staff was friendly and helpful. Our room was clean and well kept with a nice shower. The room did not have a microwave, but other than that it had everything we needed. We ate at Asia noodle and it was SO good. I'm a non-smoker so I didn't enjoy the smoke within ..."

Reviewed on Jun 29, 2026

Opens in a new windowRiver City Casino & Hotel
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
$148 nightly
The price is $173 total per night from Jul 20 to Jul 21
$173 total
Jul 20 - Jul 21
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,938 reviews)
"The bar was very good. Bartenders pay great attention to prepare each cocktails with perfections and these menus are amazingly creative. Breakfast was good, but it took over an hour to arrive. So it may not be for busy people. The room for the breakfast (cafeteria) seems too small while lobby and ..."

Reviewed on Jun 30, 2026

Opens in a new window21C Museum Hotel St Louis
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
$140 nightly
The price is $164 total per night from Jul 12 to Jul 13
$164 total
Jul 12 - Jul 13
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. ...
8.8/10 Excellent! (1,013 reviews)
"Very nice hotel super clean rooms friendly staff extremely convenient location. If I visit St. Louis again, I will definitely stay here."

Reviewed on Jun 29, 2026

Opens in a new windowThe Westin St. Louis
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4 Star Hotels Brentwood

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Brentwood 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Brentwood will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Brentwood, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Brentwood hotel reviews by fellow wanderers

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

5 out of 5
Posted 8 hours ago
Travelocity Verified Review
"The property was in an excellent location to see many tourists areas. From the valet staff to the bell staff to the check in staff everyone was extremely courteous, helpful and went out of their way to do everything for you. The entire property was well maintained and clean. Our room was clean, well stocked with towels and amenities. The linen and beds were wonderful."
A verified traveler stayed at Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch

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