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Top hotels close to Looe Key National Marine Sanctuary

300’ Private Beach, Pool & Rooftop w Panoramic Ocean Views

Big Pine Key FL

6.66 mi from Looe Key National Marine Sanctuary

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This vacation home features a garden, laundry facilities, and barbecue grills.

Pool

Kitchen

Barnacle Resort

1557 Long Beach Dr Big Pine Key FL

7.04 mi from Looe Key National Marine Sanctuary

$215 nightly

$242 total

Jun 16 - Jun 17

Total with taxes and fees

A rooftop terrace, free self parking, and barbecue grills are featured at this bed & breakfast. WiFi in public areas is free. Luggage storage is also provided.

Parking included

Free WiFi

Treehouse Private Village Barnacle Resort

Big Pine Key FL

7.04 mi from Looe Key National Marine Sanctuary

$655 nightly

$716 total

Jun 16 - Jun 17

Total with taxes and fees

This cabin includes a garden and barbecue grills.

Kitchen

Pet friendly

Star Room Barnacle Resort

Big Pine Key FL

7.04 mi from Looe Key National Marine Sanctuary

$286 nightly

$311 total

Jun 16 - Jun 17

Total with taxes and fees

This apartment includes a garden and barbecue grills.

Pet friendly

Air conditioning

Beach View Room Dormitory Room Barnacle Resort

Big Pine Key FL

7.04 mi from Looe Key National Marine Sanctuary

$445 nightly

$484 total

Jun 17 - Jun 18

Total with taxes and fees

This apartment includes a garden and barbecue grills.

Pet friendly

Air conditioning

Ocean View Suite Barnacle Resort

Big Pine Key FL

7.04 mi from Looe Key National Marine Sanctuary

$461 nightly

$499 total

Jun 17 - Jun 18

Total with taxes and fees

This apartment includes a garden and barbecue grills.

Pet friendly

Air conditioning

Beachfront 3B/3B Fishing Oasis

Ramrod Key FL

7.11 mi from Looe Key National Marine Sanctuary

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An outdoor pool is featured at this vacation home, along with laundry facilities and barbecue grills.

Pool

Kitchen

Kraken's Cove: 4‑bedroom Ramrod Key escape, minutes from open water

Summerland Key FL

7.13 mi from Looe Key National Marine Sanctuary

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This vacation home features laundry facilities.

Washer

Dryer

Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool

Big Pine Key FL

7.16 mi from Looe Key National Marine Sanctuary

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This vacation home features an outdoor pool and a hot tub. Families will appreciate the playground and onsite laundry facilities. Barbecue grills are provided for your convenience.

Pool

Hot Tub

Sirena Key | Luxury Oceanfront Estate, Pool, Guest Cottage, Dock, 30min to Key West

Summerland Key FL

7.25 mi from Looe Key National Marine Sanctuary

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A hot tub is featured at this vacation home, along with a garden and barbecue grills.

Pool

Hot Tub

Spacious 7-bedroom estate with AC in peaceful Summerland Key

Summerland Key FL

7.27 mi from Looe Key National Marine Sanctuary

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A gym is featured at this vacation home, along with laundry facilities.

Washer

Dryer

Gorgeous Beachfront Home with a pool. Water views from every direction.

Big Pine Key FL

7.35 mi from Looe Key National Marine Sanctuary

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An outdoor pool is featured at this vacation home, along with laundry facilities and barbecue grills.

Pool

Kitchen

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Looe Key National Marine Sanctuary hotels essential information

Accommodation	778 hotels
Lowest Price	$242
Highest Price	$716
Popular hotels	300’ Private Beach, Pool & Rooftop w Panoramic Ocean Views, Barnacle Resort, Treehouse Private Village Barnacle Resort, Star Room Barnacle Resort, Beach View Room Dormitory Room Barnacle Resort, Ocean View Suite Barnacle Resort, Beachfront 3B/3B Fishing Oasis, Kraken's Cove: 4‑bedroom Ramrod Key escape, minutes from open water, Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool, Sirena Key \| Luxury Oceanfront Estate, Pool, Guest Cottage, Dock, 30min to Key West, Spacious 7-bedroom estate with AC in peaceful Summerland Key, Gorgeous Beachfront Home with a pool. Water views from every direction.

Recent Looe Key National Marine Sanctuary hotel reviews by fellow wanderers

Beachfront 3B/3B Fishing Oasis

5 out of 5

Posted 2 months ago

Travelocity Verified Review

"This house was exactly how we like to vacation. The property is cozy with a laid-back easy-living vibe. Perfect place to launch your kayaks, then lounge in the pool afterwards. Great water views with no mangroves to interrupt it.The kitchen was fully stocked with all the dishes, pots/pans, and appliances you could need. Gas grill downstairs. I did try out the pizza oven, but it was just too windy for it to be effective.There are many very good Cuban restaurants nearby. 8 minutes to Big Pine where you’ll find more restaurants, shops, and Winn-Dixie for groceries. 30 miles into Key West if you feel the need to be a tourist.Definitely want to return for another stay if the property (which is for sale) remains on the vacation rental market.We stayed for a month in April and the temperatures were perfect."

A verified traveler stayed at Beachfront 3B/3B Fishing Oasis

Barnacle Resort

1 out of 5

Posted 2 months ago

Travelocity Verified Review

"Absolutely horrible stay. It took over an hour to get the key code. The place looks like an unfinished Boy Scout project. Everything is old and dirty and rusty . Cigarette butts on the beach. Everything is rundown and damaged. I don’t believe that there was even a credible architect building this place. I felt like I was in a horror movie. Last but not least We found out that the place is for sale…..No wonder !"

A verified traveler stayed at Barnacle Resort

Treehouse Private Village Barnacle Resort

5 out of 5

Posted 2 months ago

Travelocity Verified Review

"Barnacle Resort Stayed 3 nights at the “Treehouse Private Village” in the Barnacle Resort on Big Pine Key. I really enjoyed my stay, the property is quite nice, and very private. One of the attractions on Big Pine Key is seeing Key deer, which astonishingly wandered around the resort property several times a day. Don’t touch or feed them, very illegal, but you can get quite close, as they are fairly tame.It wasn’t clear when I made my reservation just where the room was on the property, since the pictures mainly showed the larger building. As it turns out, my reservation was for the separate, smaller building next to the main house. The “Treehouse” was completely private, and has its own kitchen and full bath, which I really appreciated. There are three or four available rooms in the main building, along with the common areas for dining, etc. So be sure you have the correct room information when you book your stay.There were a couple of things I had to deal with, like the TV wasn’t plugged in, no power outlets in the kitchen for the coffee machine (ran it off the floor in the main room), but really nothing major. And the host responded quickly to any questions, plus I think there’s folks onsite for anything that might be needed.All in all, I was quite pleased with my experience there. If natural beauty, privacy, and location close to Bahia Honda State Park and Key West are at the top of your list, check this place out."

A verified traveler stayed at Treehouse Private Village Barnacle Resort

Star Room Barnacle Resort

3 out of 5

Posted 3 months ago

Travelocity Verified Review

"By the description of the property I was was hoping for an amazing experience. The house exterior looked like it was in need of clean up. It just looked like the construction crew left and no one did detail cleaning Our room was on the upper level. It was called the Star room. Apparently there was a methane gas leak somewhere, as our room, the entire stay smelled like an unflushed toilet. It was a lingering odor. We had fans in the room, which helped. The house has this lovely weather vane on the top of the roof, which rotated with the wind. Unfortunately, it needed greasing! It squeaked and made noise all night! I was never able to speak directly to the management. I could only leave a message, and I was never called back. So, if you do rent at this VRBO, be aware,, no management will be of any help. "

A verified traveler stayed at Star Room Barnacle Resort

Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool

5 out of 5

Posted 4 months ago

Travelocity Verified Review

"We just spent 31 nights in Jan/Feb 2026 celebrating our 48th wedding anniversary. The location was perfect for exploring all the keys. We even drove up to Miami Beach one day and was easy to get back before sunset. The location was great for day trips to Key West, getting there in less than 45 minutes. The house is on a very quiet dead-end road. There is a convenience store within 2 miles and a Winn-Dixie within 5 miles. The bird life and key deer on the beach were amazing. The heated pool was so nice and well maintained. The large washer and dryer were very nice. The Kitchen had everything we needed. The place was relaxing. Greg was very helpful and attentive. We would give this place more than 5 stars if we could."

A verified traveler stayed at Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool

Gorgeous Beachfront Home with a pool. Water views from every direction.

5 out of 5

Posted 7 months ago

Travelocity Verified Review

"Our family really enjoyed our stay at this beautiful home. Amazing views from every room. The deck sitting areas were screen in and very comfortable. We all enjoyed sitting on the deck looking at the ocean and seeing the Key Deer pass by. The deer brought so much joy to our grandchildren! John and the property managerwere very accommodating during our stay. Thank you for a wonderful vacation!"

A verified traveler stayed at Gorgeous Beachfront Home with a pool. Water views from every direction.