Find a Hotel in La Jolla Mesa

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Top hotels in La Jolla Mesa

Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street San Diego CA
Fully refundableReserve now, pay when you stay
$370 nightly
The price is $429 total per night from Jan 18 to Jan 19
$429 total
Jan 18 - Jan 19
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
The room was clean, tasteful, and quiet. The staff was very friendly and helpful. We had a wonderful time in Pendry.

Reviewed on Jan 1, 2026

Opens in a new windowPendry San Diego
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from Jan 20 to Jan 21
$160 total
Jan 20 - Jan 21
Total with taxes and fees
A marina, a gym, and a restaurant are all featured at this traditional hotel. Traveling on business? Take advantage of the free WiFi in public areas and free ...
Friendly staff n food is great

Reviewed on Jan 12, 2026

Opens in a new windowBay Club Hotel & Marina
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $128 total per night from Jan 22 to Jan 23
$128 total
Jan 22 - Jan 23
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Yes

Reviewed on Jan 11, 2026

Opens in a new windowThe DEXTRO Little Italy, BW Premier Collection
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $161 total per night from Jan 19 to Jan 20
$161 total
Jan 19 - Jan 20
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and free internet ...
The staff was amazing. The room was clean and very comfortable. The only complaint was not all elevators were in operation. This caused a tremendous wait time.

Reviewed on Jan 12, 2026

Opens in a new windowCourtyard by Marriott San Diego Downtown Little Italy
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $206 total per night from Jan 18 to Jan 19
$206 total
Jan 18 - Jan 19
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
Nice place. I saw what others said about needing some updates as they could paint in bathrooms, trims, etc but let’s be real…I was on vacation and slept there and got up and hit the sights again. Was it the nicest place I’ve ever stayed? No but it was just fine! My only complaint is how early the ...

Reviewed on Jan 12, 2026

Opens in a new windowThe Dana on Mission Bay
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$237 nightly
The price is $274 total per night from Jan 18 to Jan 19
$274 total
Jan 18 - Jan 19
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy a meal in one of the 2 coffee shops/cafes and perks like free ...
Very good

Reviewed on Jan 9, 2026

Opens in a new windowHard Rock Hotel San Diego
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$226 nightly
The price is $260 total per night from Feb 6 to Feb 7
$260 total
Feb 6 - Feb 7
Total with taxes and fees
A marina, 5 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi ...
The room clean, the area safe and the staff friendly

Reviewed on Jan 11, 2026

Opens in a new windowSheraton San Diego Resort
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4 out of 5
7450 Hazard Center Dr San Diego CA
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $138 total per night from Jan 25 to Jan 26
$138 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 20 conference rooms, free WiFi in public areas, ...
Lovely staff, there were ants in the bathroom

Reviewed on Jan 10, 2026

Opens in a new windowDoubleTree by Hilton Hotel San Diego - Mission Valley
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $141 total per night from Jan 21 to Jan 22
$141 total
Jan 21 - Jan 22
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Room was clean, Hotel was in a great location to areas we wanted to visit, staff was courteous and was able to resolve issues with gate quickly

Reviewed on Jan 14, 2026

Opens in a new windowHilton San Diego Mission Valley
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

La Jolla Mesa Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on La Jolla Mesa area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near La Jolla Mesa to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near La Jolla Mesa are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent La Jolla Mesa hotel reviews by fellow wanderers

Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

5 out of 5
Posted 16 hours ago
Travelocity Verified Review
"Room was clean, Hotel was in a great location to areas we wanted to visit, staff was courteous and was able to resolve issues with gate quickly"
A verified traveler stayed at Hilton San Diego Mission Valley
Hilton San Diego Mission Valley

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