Explore top 2025 5 Star Hotels in Lake Nona Medical City
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Top Lake Nona Medical City 5 Star hotels
Waldorf Astoria Orlando - An Official Walt Disney World® Hotel
14200 Bonnet Creek Resort Lane, Orlando, FL
Fully refundableReserve now, pay when you stay
$417 nightly
The price is $469 total per night from Oct 16 to Oct 17
$469 total
Oct 16 - Oct 17
Total with taxes and fees
This luxury resort features a golf course, a full-service spa, and 12 restaurants. There's fun for all ages with a lazy river and a children's club, and families ...
9.2/10 Wonderful! (363 reviews)
"Wonderful Hotel"
Reviewed on Sep 20, 2025
Conrad Orlando at Evermore
1500 Eastbeach Way, Orlando, FL
Fully refundableReserve now, pay when you stay
$466 nightly
The price is $525 total per night from Oct 3 to Oct 4
$525 total
Oct 3 - Oct 4
Total with taxes and fees
This luxury resort features a private beach, a golf course, and a full-service spa. Relax with beach cabanas, sun loungers, and beach umbrellas. Bring the family ...
9.4/10 Exceptional! (289 reviews)
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Reviewed on Sep 17, 2025
The Ritz-Carlton Orlando, Grande Lakes
4012 Central Florida Parkway, Orlando, FL
Fully refundableReserve now, pay when you stay
$464 nightly
The price is $522 total per night from Sep 27 to Sep 28
$522 total
Sep 27 - Sep 28
Total with taxes and fees
This smoke-free hotel features a golf course, a full-service spa, and 7 restaurants. There's fun for all ages with a lazy river and a children's club, and families ...
9.2/10 Wonderful! (1,008 reviews)
"The stay could not have been more perfect. Will stay as often as we can."
Reviewed on Sep 21, 2025
Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort
10100 Dream Tree Blvd., Lake Buena Vista, FL
Fully refundableReserve now, pay when you stay
$1,040 nightly
The price is $1,170 total per night from Oct 1 to Oct 2
$1,170 total
Oct 1 - Oct 2
Total with taxes and fees
This luxury resort features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, ...
9.6/10 Exceptional! (869 reviews)
"An amazing stay at the Four Seasons Orlando! The service was outstanding, the pools (especially the lazy river) were fantastic, and the on-site restaurants offered excellent dining options. Truly a perfect experience from start to finish."
Reviewed on Sep 14, 2025
ette hotel
3001 Sherberth Rd, Kissimmee, FL
Fully refundableReserve now, pay when you stay
$280 nightly
The price is $318 total per night from Sep 29 to Sep 30
$318 total
Sep 29 - Sep 30
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.6/10 Exceptional! (338 reviews)
"I would say without question if I could give Ette Hotel 6 stars I would. The hotel is modern and spotless amazingly comfortable beds and linens. This is a reasonably small hotel personal recognition by the staff made our stay an in even happier experience. Great location especially for Disney but ..."
Reviewed on Sep 18, 2025
Reunion Resort & Golf Club
7593 Gathering Drive, Kissimmee, FL
This luxury aparthotel features a golf course, free water park access, and 7 restaurants. Bring the family and enjoy the lazy river, mini golf, and kid-friendly ...
8.6/10 Excellent! (1,396 reviews)
"We have been guests of Reunion for several years now. We love the golf"
Reviewed on Sep 17, 2025
Encore Resort and Water Park at Reunion by Rentyl
7635 Fairfax Dr, Kissimmee, FL
Fully refundableReserve now, pay when you stay
$649 nightly
The price is $737 total per night from Sep 27 to Sep 28
$737 total
Sep 27 - Sep 28
Total with taxes and fees
This smoke-free resort features free water park access, a full-service spa, and 2 restaurants. There's fun for all ages with a free kid's club and a children's ...
8.2/10 Very Good! (1,006 reviews)
"Perfecto lugar para pasarlo en familia"
Reviewed on Sep 15, 2025
Luxurious 2 Bd Close to Disney @ Storey Lake 204 3131
3131 Paradox Circle, Unit 204, Kissimmee, FL
A golf course, free water park access, and 2 outdoor pools are all featured at this smoke-free vacation home. There's fun for all ages with a lazy river and ...
10/10 Exceptional! (4 reviews)
"It was a clean and nice"
Reviewed on Sep 13, 2025
Gorgeous 4 Bedroom w/ Pool Close to Disney 4836
4836 Dedication Street, Kissimmee, FL
Free water park access and an outdoor pool are featured at this luxury vacation home. Bring the family and enjoy the lazy river, children's pool, and waterslide. ...
9.4/10 Exceptional! (12 reviews)
"Clean, loved the pool"
Reviewed on Sep 18, 2025
Amazing 4Bd Screened Pool Close to Disney 4572
4572 Baleno Ln, Kissimmee, FL
Free water park access and an outdoor pool are featured at this luxury vacation home. There's fun for all ages with a lazy river and a children's pool, and families ...
9.6/10 Exceptional! (4 reviews)
"The dryer didnt work and No Highchair , also never received my tickets to Water park with Lazy pool ticket. Other than that My Family enjoyed Everything. Pool is a Plus"
Reviewed on May 28, 2025
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Lake Nona Medical City hotel reviews by fellow wanderers
Marriott's Grande Vista
5 out of 5
Posted 22 hours ago
Travelocity Verified Review
"Clean room"
A verified traveler stayed at Marriott's Grande Vista
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