Explore top 2026 5 Star Hotels in Lake Nona Medical City
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Top Lake Nona Medical City 5 Star hotels
Waldorf Astoria Orlando - An Official Walt Disney World® Hotel
14200 Bonnet Creek Resort Lane Orlando FL
$418 nightly
The price is $470 total per night from Apr 10 to Apr 11
$470 total
Apr 10 - Apr 11
Total with taxes and fees
This luxury resort features a golf course, a full-service spa, and 12 restaurants. There's fun for all ages with a lazy river and a children's club, and families ...
9.2/10 Wonderful! (483 reviews)
Clean room and close to everything. Just wished they had more tables in the main area!
Reviewed on Mar 25, 2026
Conrad Orlando at Evermore
1500 Eastbeach Way Orlando FL
$625 nightly
The price is $704 total per night from Apr 16 to Apr 17
$704 total
Apr 16 - Apr 17
Total with taxes and fees
This luxury resort features a private beach, a golf course, and a full-service spa. Relax with beach cabanas, sun loungers, and beach umbrellas. Bring the family ...
9.6/10 Exceptional! (409 reviews)
The absolute BEST trip and most amazing resort we have ever stay at. Highly recommend and will be going back again!
Reviewed on Mar 24, 2026
Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort
10100 Dream Tree Blvd. Lake Buena Vista FL
Fully refundableReserve now, pay when you stay
$1,105 nightly
The price is $1,243 total per night from Apr 12 to Apr 13
$1,243 total
Apr 12 - Apr 13
Total with taxes and fees
This luxury resort features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, ...
9.6/10 Exceptional! (891 reviews)
Absolutely best resort in Disney area Service exceptional
Reviewed on Mar 20, 2026
The Ritz-Carlton Orlando, Grande Lakes
4012 Central Florida Parkway Orlando FL
Fully refundableReserve now, pay when you stay
$649 nightly
The price is $730 total per night from Apr 24 to Apr 25
$730 total
Apr 24 - Apr 25
Total with taxes and fees
This smoke-free hotel features a golf course, a full-service spa, and 7 restaurants. There's fun for all ages with a lazy river and a children's club, and families ...
Reunion Resort & Golf Club
7593 Gathering Drive Kissimmee FL
This luxury aparthotel features a golf course, free water park access, and 7 restaurants. Bring the family and enjoy the lazy river, mini golf, and kid-friendly ...
8.8/10 Excellent! (1,501 reviews)
Very nice place. The food options were lean. Surprised the bars and restaurants close so early and open so late.
Reviewed on Mar 25, 2026
Encore Resort and Water Park at Reunion by Rentyl
7635 Fairfax Dr Kissimmee FL
Fully refundableReserve now, pay when you stay
$629 nightly
The price is $714 total per night from Mar 29 to Mar 30
$714 total
Mar 29 - Mar 30
Total with taxes and fees
This smoke-free resort features free water park access, a full-service spa, and 2 restaurants. There's fun for all ages with a free kid's club and a children's ...
8.2/10 Very Good! (1,002 reviews)
If you are looking for a safe,, clean place to stay with your family… you may want to keep looking. Our check-in was good other than they said we were “upgraded” to a different home. This home we were placed in was not one I would have chosen if shown pictures and given the choice. This home was ...
Reviewed on Mar 25, 2026
ette hotel
3001 Sherberth Rd Kissimmee FL
Fully refundableReserve now, pay when you stay
$285 nightly
The price is $324 total per night from Apr 9 to Apr 10
$324 total
Apr 9 - Apr 10
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.6/10 Exceptional! (425 reviews)
Property is clean and beautiful. Front desk staff is fantastic -- so kind and nice. The rooms are very clean and the beds and bedding are very comfortable. BUT ... $29 + 20% service charge + tax for a vodka martini? OUTRAGEOUS! This is the most expensive cocktail I have ever ordered and I live in ...
Reviewed on Mar 23, 2026
Disney's Beach Club Resort
1800 Epcot Resort Blvd Lake Buena Vista FL
$575 nightly
The price is $647 total per night from Apr 21 to Apr 22
$647 total
Apr 21 - Apr 22
Total with taxes and fees
This luxury resort features 2 restaurants, 3 outdoor pools, and 3 hot tubs. There's fun for all ages with a children's pool and a theme park shuttle, and in-room ...
8.8/10 Excellent! (702 reviews)
Definitely did not meet expectations. It felt unsafe after an incident in the hotel and they were not accommodating in moving us out of a handicapped room. There was trash in the hallways and the rooms were worn and didnt give off a wow factor at all for the price that was paid.
Reviewed on Mar 25, 2026
Disney's Beach Club Villas
1800 Epcot Resort Blvd Lake Buena Vista FL
$710 nightly
The price is $799 total per night from Apr 26 to Apr 27
$799 total
Apr 26 - Apr 27
Total with taxes and fees
This luxury condo resort features a private beach, a marina, and 3 restaurants. Bring the family and enjoy the children's club, children's pool, and free theme ...
Splendid 5Bd Close to Disney at Storey Lake 4251
4251 Paragraph Dr Kissimmee FL
Free water park access and an outdoor pool are featured at this smoke-free vacation home. There's fun for all ages with a lazy river and a children's pool, and ...
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Lake Nona Medical City hotel reviews by fellow wanderers
Drury Plaza Hotel Orlando - Disney Springs Area
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"Our favorite hotel when visiting Disney World! Breakfast is always great and we love being able to fill our water bottles and have good coffee before hitting the parks. We often arrive back after kickbacks has ended but we really enjoy the onsite pizza and restaurant. We will definitely be back!!"
A verified traveler stayed at Drury Plaza Hotel Orlando - Disney Springs Area
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