Explore top 2025 5 Star Hotels in Lake Nona Medical City

Name: Amazing 4Bd Screened Pool Close to Disney 4572
Rating: 8

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Top Lake Nona Medical City 5 Star hotels

Waldorf Astoria Orlando - An Official Walt Disney World® Hotel

14200 Bonnet Creek Resort Lane, Orlando, FL

Fully refundableReserve now, pay when you stay

$385 nightly

$434 total

Nov 28 - Nov 29

Total with taxes and fees

This luxury resort features a golf course, a full-service spa, and 12 restaurants. There's fun for all ages with a lazy river and a children's club, and families ...

9.2/10 Wonderful! (398 reviews)

Always a pleasure staying at the Waldorf Astoria!

Reviewed on Nov 7, 2025

Conrad Orlando at Evermore

1500 Eastbeach Way, Orlando, FL

Fully refundableReserve now, pay when you stay

$535 nightly

$602 total

Dec 1 - Dec 2

Total with taxes and fees

This luxury resort features a private beach, a golf course, and a full-service spa. Relax with beach cabanas, sun loungers, and beach umbrellas. Bring the family ...

9.4/10 Exceptional! (318 reviews)

Our first time there as a staycation and we technically live 20 minutes away. Service was impeccable. The rooms were clean. The whole outdoor area of the bars, pool, and beach or pristine. The staff at all the restaurants were amazing. Food was fantastic. Custom cocktails at Cieba were out of this ...

Reviewed on Nov 7, 2025

Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort

10100 Dream Tree Blvd., Lake Buena Vista, FL

Fully refundableReserve now, pay when you stay

$1,045 nightly

$1,176 total

Nov 30 - Dec 1

Total with taxes and fees

This luxury resort features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, ...

9.6/10 Exceptional! (874 reviews)

Fantastic hotel, lovely front desk and housekeeping staff.

Reviewed on Oct 19, 2025

The Ritz-Carlton Orlando, Grande Lakes

4012 Central Florida Parkway, Orlando, FL

Fully refundableReserve now, pay when you stay

$654 nightly

$736 total

Nov 14 - Nov 15

Total with taxes and fees

This smoke-free hotel features a golf course, a full-service spa, and 7 restaurants. There's fun for all ages with a lazy river and a children's club, and families ...

9.2/10 Wonderful! (1,013 reviews)

Great service great accommodation can’t fault it

Reviewed on Oct 26, 2025

ette hotel

3001 Sherberth Rd, Kissimmee, FL

Fully refundableReserve now, pay when you stay

$292 nightly

$331 total

Nov 11 - Nov 12

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...

9.6/10 Exceptional! (356 reviews)

Everything was flawless. The place, the room, the pool, the food (OMG the food), the staff, the toiletries. Marcus, Gino. Everyone. Wonderful. I would stay here a thousand times again

Reviewed on Nov 2, 2025

Reunion Resort & Golf Club

7593 Gathering Drive, Kissimmee, FL

$339 nightly

$385 total

Dec 10 - Dec 11

Total with taxes and fees

This luxury aparthotel features a golf course, free water park access, and 7 restaurants. Bring the family and enjoy the lazy river, mini golf, and kid-friendly ...

8.6/10 Excellent! (1,421 reviews)

Well stocked kitchen, clean unit and quiet

Reviewed on Nov 2, 2025

Encore Resort and Water Park at Reunion by Rentyl

7635 Fairfax Dr, Kissimmee, FL

Fully refundableReserve now, pay when you stay

$629 nightly

$714 total

Nov 11 - Nov 12

Total with taxes and fees

This smoke-free resort features free water park access, a full-service spa, and 2 restaurants. There's fun for all ages with a free kid's club and a children's ...

8.2/10 Very Good! (1,001 reviews)

We had a great stay at Encore Resort. The house was clean, spacious, and perfect for multiple families. There was plenty of room for everyone and the kids especially had an amazing time. Overall, we really enjoyed our stay and would absolutely come back again.

Reviewed on Nov 3, 2025

Luxurious 2 Bd Close to Disney @ Storey Lake 204 3131

3131 Paradox Circle, Unit 204, Kissimmee, FL

A golf course, free water park access, and 2 outdoor pools are all featured at this smoke-free vacation home. There's fun for all ages with a lazy river and ...

10/10 Exceptional! (4 reviews)

It was a clean and nice

Reviewed on Sep 13, 2025

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Splendid 5Bd Close to Disney at Storey Lake 4251

4251 Paragraph Dr, Kissimmee, FL

Free water park access and an outdoor pool are featured at this smoke-free vacation home. There's fun for all ages with a lazy river and a children's pool, and ...

9.2/10 Wonderful! (12 reviews)

Very beautiful and clean property.

Reviewed on Mar 17, 2025

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Amazing 4Bd Screened Pool Close to Disney 4572

4572 Baleno Ln, Kissimmee, FL

Free water park access and an outdoor pool are featured at this luxury vacation home. There's fun for all ages with a lazy river and a children's pool, and families ...

8/10 Very Good! (5 reviews)

The dryer didnt work and No Highchair , also never received my tickets to Water park with Lazy pool ticket. Other than that My Family enjoyed Everything. Pool is a Plus

Reviewed on May 28, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.