Book Hotels in Depew, NY
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Depew hotels
Holiday Inn Express Grand Island - Niagara Falls by IHG
Everything was fabulous that was in control of the facility. However, we had guess that we’re running upstairs and beside us until 11 PM, so we were unable to sleep and get up early. Walls were thin, I wore earplugs and still fear people The facilities and the breakfast were fabulous!!
Reviewed on May 2, 2026
Wyndham Garden Buffalo Downtown
I can only rate this hotel a 10 of a 10. The property is immaculate and located in the heart of downtown Buffalo minutes walk to great bars and restaurants. The hotel offers complementary transportation for free to any restaurant you would like to go which was great. The rooms are sparkling clean ...
Reviewed on May 3, 2026
Tru by Hilton Williamsville Buffalo Airport
Love the pool and game area! Great for kids and families pets tooo
Reviewed on May 1, 2026
La Quinta Inn & Suites by Wyndham Buffalo Amherst
I appreciate that the staff worked quickly to get my checked in earlier in the day, however, the room was not thoroughly cleaned. I ended up having to clean the toilet and surrounding areas, myself. Carpet smelled old and the entire room was scuffed up heavily. Personally I was just a bit skeeved ...
Reviewed on May 2, 2026
Sleep Inn & Suites Buffalo Airport
Great hotel.
Reviewed on May 3, 2026
Buffalo Airport Hotel
Lights didn’t work in the room. The room had a strong cigarette smell and even to the bedsheets. Bath tub didn’t look clean to even take a shower.
Reviewed on May 3, 2026
La Quinta Inn by Wyndham Buffalo Airport
The shower soap dispenser was empty, the shower door constructed so that the only door that opened was not near shower control, therefore scalding or freezing me when i had to step in to turn them on. Towels were as rough as sandpaper, there was no fan in the bathroom for odors or steam. That all ...
Reviewed on May 3, 2026
Garden Place Hotel
This hotel had a great historic look to it. The bed was extremely comfortable and the curtains did not let any light in at night.
Reviewed on May 3, 2026
M Hotel Buffalo
Loved the room that opened up to the pool, pool is a little smaller than I had thought but still enjoyable. Breakfast was great.
Reviewed on May 3, 2026
Depew Hotel & Travel Guide\n
If you're thinking of exploring the Buffalo area and are looking for a place to stay in Depew, Travelocity offers an exciting assortment to decide between. Inside the resourceful booking pages, the modern traveler will find 50 flexible accommodation options within a 6-mile (10-kilometer) distance of Depew's center.
Visitors searching for a hotel in the heart of Depew should plan to stay at Pink Fountain Motor Inn.
9 miles (14 kilometers) from the town center of Depew, you will find the The Mansion On Delaware Ave. Alternatively, the Lofts on Pearl is positioned 9 miles (14 kilometers) away. Other possible Travelocity-listed hotels are the Hampton Inn & Suites Buffalo Downtown and the Hotel @ The Lafayette.
After you have seen Depew, put aside some time to investigate the other natural and cultural attractions of the Niagara Falls - Western New York area. Get to know Niagara Falls - Western New York's art galleries and theaters. You should also make the time to admire its lakes. Wise visitors in this part of United States of America will enjoy ice skating and guided nature walks.
8 miles (12 kilometers) to the west of Depew, you can reach Downtown Buffalo, home to Greater Buffalo Sports Hall of Fame and Old Erie County Hall. Some of our recommended Downtown Buffalo hotels and accommodations include the Embassy Suites Buffalo and Hyatt Regency Buffalo / Hotel and Conference Center. 9 miles (15 kilometers) to the northwest of Depew, you can also stay at Amherst, home to the Homewood Suites by Hilton Buffalo/Amherst and Residence Inn Buffalo Amherst. Should you choose to stay in Amherst, set aside some time to explore the Boulevard Mall and Lasertron.
Simply because you and your traveling partners are taking a break from your usual habits, who says you can't enjoy your passion for a day of sports. You can find First Niagara Center 9 miles (14 kilometers) to the west of Depew. Sleep right in the thick of the sporting action at the Holiday Inn Buffalo-Downtown or the Holiday Inn Express & Suites Buffalo Downtown.
For travelers flying through Buffalo Niagara International Airport, you may like to book some accommodation at Staybridge Suites Buffalo-Airport, or Hilton Garden Inn Buffalo Airport, each of which are conveniently located nearby.
Frequently asked questions
Recent Depew hotel reviews by fellow wanderers
Sleep Inn & Suites Buffalo Airport
Explore More Ways to Travel with Travelocity
- Hotels near Patriots and Heroes Park
- Lancaster Hotels
- Hotels near Buffalo Museum of Science
- Hotels near Millard Fillmore Suburban Hospital
- Hotels near Buffalo Central Terminal
- Cottages in Buffalo-Depew Station
- Hotels near Buffalo-Depew Station
- Extended Stay Hotels in Cheektowaga
- Cheektowaga Hotels
- Bowmansville Hotels
- Amherst Hotels
- Hotels near Daemen College
- Hotels near Southgate Plaza
- Harris Hill Hotels
- Hotels near Walden Galleria Mall
- West Seneca Hotels
- East Seneca Hotels
- Hotels near Broadway Market
- Hotels near Samuel’s Grande Manor
- Snyder Hotels
- Williamsville Hotels
- Hotels near University at Buffalo - South Campus
- Hotels near Holiday Twin Rinks
- Hotels near Cazenovia Golf Course
- Hotels near Glen Falls
- Sloan Hotels
- Hotels near Reinstein Woods Nature Preserve and Environmental Education Center
- Elma Center Hotels
- Hotels near Eastern Hills Mall
- Hotels near Buffalo Niagara Intl.
- Hotels near Enjoy The Journey Art Gallery
- Buffalo Hotels
- Flights from Buffalo Niagara Intl.
- American Airlines Austin (AUS) to Buffalo (BUF) flights
- American Airlines Indianapolis (IND) to Buffalo (BUF) flights
- American Airlines Miami (MIA) to Buffalo (BUF) flights
- Delta Las Vegas (LAS) to Buffalo (BUF) flights
- Delta Atlanta (ATL) to Buffalo (BUF) flights
- Delta New York (JFK) to Buffalo (BUF) flights
- Delta Minneapolis (MSP) to Buffalo (BUF) flights
- Jetblue Airways Fort Lauderdale (FLL) to Buffalo (BUF) flights
- Jetblue Airways New York (JFK) to Buffalo (BUF) flights
- Jetblue Airways Boston (BOS) to Buffalo (BUF) flights
- Jetblue Airways Los Angeles (LAX) to Buffalo (BUF) flights
- Jetblue Airways Orlando (MCO) to Buffalo (BUF) flights
- Jetblue Airways West Palm Beach (PBI) to Buffalo (BUF) flights
- Flights from Albany (ALB) to Buffalo (BUF)
- Flights from Atlanta (ATL) to Buffalo (BUF)
- Flights from Asheville (AVL) to Buffalo (BUF)
- Flights from Hartford (BDL) to Buffalo (BUF)
- Flights from Nashville (BNA) to Buffalo (BUF)
- Flights from Boston (BOS) to Buffalo (BUF)
- Flights from Baltimore (BWI) to Buffalo (BUF)
- Flights from Charleston (CHS) to Buffalo (BUF)
- Flights from Charlotte (CLT) to Buffalo (BUF)
- Flights from Columbus (CMH) to Buffalo (BUF)
- Flights from Washington (DCA) to Buffalo (BUF)
- Flights from Denver (DEN) to Buffalo (BUF)
- Flights from Dallas (DFW) to Buffalo (BUF)
- Flights from Detroit (DTW) to Buffalo (BUF)
- Flights from Newark Liberty Intl. Airport (EWR) to Buffalo (BUF)
- Flights from Greenville (GSP) to Buffalo (BUF)
- Flights from Houston (HOU) to Buffalo (BUF)
- Flights from White Plains (HPN) to Buffalo (BUF)
- Flights from Washington (IAD) to Buffalo (BUF)
- Flights from Houston (IAH) to Buffalo (BUF)
- Flights from Wilmington (ILM) to Buffalo (BUF)
- Flights from Islip (ISP) to Buffalo (BUF)
- Flights from Jacksonville (JAX) to Buffalo (BUF)
- Flights from New York (JFK) to Buffalo (BUF)
- Flights from New York (LGA) to Buffalo (BUF)
- Flights from Kansas City (MCI) to Buffalo (BUF)
- Flights from Orlando (MCO) to Buffalo (BUF)
- Flights from Oklahoma City (OKC) to Buffalo (BUF)
- Flights from Chicago (ORD) to Buffalo (BUF)
- Flights from Norfolk (ORF) to Buffalo (BUF)
- Flights from Portland (PDX) to Buffalo (BUF)
- Flights from Philadelphia (PHL) to Buffalo (BUF)
- Flights from Phoenix (PHX) to Buffalo (BUF)
- Flights from Pittsburgh (PIT) to Buffalo (BUF)
- Flights from Providence (PVD) to Buffalo (BUF)
- Flights from Raleigh (RDU) to Buffalo (BUF)
- Flights from Richmond (RIC) to Buffalo (BUF)
- Flights from Fort Myers (RSW) to Buffalo (BUF)
- Flights from San Diego (SAN) to Buffalo (BUF)
- Flights from Savannah (SAV) to Buffalo (BUF)
- Flights from Seattle (SEA) to Buffalo (BUF)
- Flights from San Francisco (SFO) to Buffalo (BUF)
- Flights from Salt Lake City (SLC) to Buffalo (BUF)
- Flights from Sacramento (SMF) to Buffalo (BUF)
- Flights from Sarasota (SRQ) to Buffalo (BUF)
- Flights from St. Louis (STL) to Buffalo (BUF)
- Flights from Tampa (TPA) to Buffalo (BUF)
- Flights to Buffalo
