Explore top 2026 5 Star Hotels in Lake Nona Medical City
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Top Lake Nona Medical City 5 Star hotels
Waldorf Astoria Orlando - An Official Walt Disney World® Hotel
14200 Bonnet Creek Resort Lane Orlando FL
Fully refundableReserve now, pay when you stay
$454 nightly
The price is $511 total per night from Jan 10 to Jan 11
$511 total
Jan 10 - Jan 11
Total with taxes and fees
This luxury resort features a golf course, a full-service spa, and 12 restaurants. There's fun for all ages with a lazy river and a children's club, and families ...
9.2/10 Wonderful! (436 reviews)
Hotel was perfect and staff were excellent except for at breakfast where the wait for a table was 30 min and the staff were not friendly
Reviewed on Jan 2, 2026
Conrad Orlando at Evermore
1500 Eastbeach Way Orlando FL
Fully refundableReserve now, pay when you stay
$683 nightly
The price is $769 total per night from Jan 29 to Jan 30
$769 total
Jan 29 - Jan 30
Total with taxes and fees
This luxury resort features a private beach, a golf course, and a full-service spa. Relax with beach cabanas, sun loungers, and beach umbrellas. Bring the family ...
9.4/10 Exceptional! (350 reviews)
Service Staff Food Accommodations
Reviewed on Dec 30, 2025
Four Seasons Resort Orlando at WALT DISNEY WORLD® Resort
10100 Dream Tree Blvd. Lake Buena Vista FL
Fully refundableReserve now, pay when you stay
$1,105 nightly
The price is $1,243 total per night from Jan 19 to Jan 20
$1,243 total
Jan 19 - Jan 20
Total with taxes and fees
This luxury resort features a golf course, free water park access, and a full-service spa. There's fun for all ages with a lazy river and a children's pool, ...
9.6/10 Exceptional! (877 reviews)
We love this hotel. The rooms are lovely and beds so comfy and the pool area is exceptional with great staff.
Reviewed on Nov 14, 2025
The Ritz-Carlton Orlando, Grande Lakes
4012 Central Florida Parkway Orlando FL
Fully refundableReserve now, pay when you stay
$734 nightly
The price is $826 total per night from Jan 29 to Jan 30
$826 total
Jan 29 - Jan 30
Total with taxes and fees
This smoke-free hotel features a golf course, a full-service spa, and 7 restaurants. There's fun for all ages with a lazy river and a children's club, and families ...
9.2/10 Wonderful! (1,001 reviews)
Both restaurants and service is one of the best in the hotel .
Reviewed on Dec 28, 2025
ette hotel
3001 Sherberth Rd Kissimmee FL
Fully refundableReserve now, pay when you stay
$334 nightly
The price is $380 total per night from Jan 22 to Jan 23
$380 total
Jan 22 - Jan 23
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business ...
9.6/10 Exceptional! (385 reviews)
The customer support was outstanding. The hotel was spotless. We received celebrity-like treatment. The rooms were large and exceptionally clean. The beds were extremely comfortable. Really enjoyed our stay.
Reviewed on Dec 28, 2025
Encore Resort and Water Park at Reunion by Rentyl
7635 Fairfax Dr Kissimmee FL
Fully refundableReserve now, pay when you stay
$629 nightly
The price is $714 total per night from Jan 11 to Jan 12
$714 total
Jan 11 - Jan 12
Total with taxes and fees
This smoke-free resort features free water park access, a full-service spa, and 2 restaurants. There's fun for all ages with a free kid's club and a children's ...
8.2/10 Very Good! (1,003 reviews)
House was clean and spacious, water park was fun, location to parks was great.
Reviewed on Jan 4, 2026
Reunion Resort & Golf Club
7593 Gathering Drive Kissimmee FL
This luxury aparthotel features a golf course, free water park access, and 7 restaurants. Bring the family and enjoy the lazy river, mini golf, and kid-friendly ...
8.6/10 Excellent! (1,451 reviews)
Very nice and clean accommodations. The only negative was we were told our wristbands gave us access to all resort amenities, but they failed to mention there’s fees involved with everyone of them. The water park was awesome, but the food service there was pitiful. Stood in line for 45 minutes both ...
Reviewed on Dec 30, 2025
Disney's Beach Club Resort
1800 Epcot Resort Blvd Lake Buena Vista FL
$517 nightly
The price is $581 total per night from Jan 8 to Jan 9
$581 total
Jan 8 - Jan 9
Total with taxes and fees
This luxury resort features 2 restaurants, 3 outdoor pools, and 3 hot tubs. There's fun for all ages with a children's pool and a theme park shuttle, and in-room ...
8.8/10 Excellent! (698 reviews)
Very nice place to stay in Disney World resort place for vacation which has shuttle buses for every where and walking distance to EPCOT. Wonderful experience there!
Reviewed on Dec 18, 2025
Gorgeous Two Bedroom Apt Close to Disney 306 4721 @Storey Lake Resort
4721 Clock Tower Drive Kissimmee FL
Free water park access and an outdoor pool are featured at this smoke-free condo. There's fun for all ages with a lazy river and a children's pool, and families ...
8.4/10 Very Good! (10 reviews)
The complex was nice and very nice clean rooms, the water park was nice and huge. Definitely would visit again
Reviewed on Mar 26, 2025
Gorgeous 2Bd Apto Close to Disney @ Storey Lake 404 3191
3191 Paradox Cir #404 Kissimmee FL
Free water park access and an outdoor pool are featured at this luxury apartment. There's fun for all ages with a lazy river and a children's pool, and families ...
10/10 Exceptional! (4 reviews)
Parking was easy.
Reviewed on Dec 19, 2025
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Recent Lake Nona Medical City hotel reviews by fellow wanderers
DoubleTree by Hilton at the Entrance to Universal Orlando
5 out of 5
Posted 14 hours ago
Travelocity Verified Review
"Room was clean. Universal is a walk away. It has close food places if you want to walk to them. This is my 2nd time staying here. Book it. "
A verified traveler stayed at DoubleTree by Hilton at the Entrance to Universal Orlando
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