Explore top 2026 5 Star Hotels in Clayton
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Top Clayton 5 Star hotels
The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
Fully refundableReserve now, pay when you stay
$499 nightly
The price is $583 total per night from Mar 15 to Mar 16
$583 total
Mar 15 - Mar 16
Total with taxes and fees
This smoke-free hotel's 2 restaurants, 3 bars/lounges, and gym are some of the featured amenities. Traveling on business? Take advantage of the 24-hour business ...
Four Seasons Hotel St Louis
999 North Second Street St. Louis MO
Fully refundableReserve now, pay when you stay
$325 nightly
The price is $380 total per night from Mar 16 to Mar 17
$380 total
Mar 16 - Mar 17
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Families will appreciate kid-friendly dining and in-room childcare. ...
9.4/10 Exceptional! (1,001 reviews)
Top notch in every way. From the moment you walk in, it’s what you would expect from a 5-Star Hotel. Highly recommended.
Reviewed on Mar 9, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Clayton hotel reviews by fellow wanderers
Pear Tree Inn St. Louis Near Union Station
4 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Staff was very helpful and friendly "
A verified traveler stayed at Pear Tree Inn St. Louis Near Union Station
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