Book a hotel near Louisville Science Center, Downtown Louisville

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Top hotels close to Louisville Science Center

21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
700 W Main Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.03 mi from Louisville Science Center
$143 nightly
The price is $169 total per night
$169 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. You'll appreciate the gym, bar/lounge, and laundry facilities.
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

3 out of 5
635 W Market St Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.1 mi from Louisville Science Center
$100 nightly
The price is $118 total per night
$118 total
Dec 19 - Dec 20
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
The Grady

The Grady

4 out of 5
601 W Main St Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.11 mi from Louisville Science Center
$139 nightly
The price is $164 total per night
$164 total
Dec 21 - Dec 22
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a coffee shop, and a library are also offered.
Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

2.5 out of 5
800 W Market St Louisville KY
0.14 mi from Louisville Science Center
$76 nightly
The price is $90 total per night
$90 total
Dec 3 - Dec 4
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast and free WiFi. Business travelers can take advantage of the 24-hour business center. There's a 24-hour gym on site, and laundry facilities and free newspapers are also offered.
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

3 out of 5
801 WEST JEFFERSON STREET Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.19 mi from Louisville Science Center
$97 nightly
The price is $114 total per night
$114 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features an indoor pool and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.32 mi from Louisville Science Center
$109 nightly
The price is $128 total per night
$128 total
Dec 15 - Dec 16
Total with taxes and fees
A full-service spa, 4 restaurants, and a gym are all featured at this hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. You'll appreciate the seasonal outdoor pool, bar/lounge, and snack bar/deli.
Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
320 West Jefferson Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.42 mi from Louisville Science Center
$116 nightly
The price is $136 total per night
$136 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a gym on site, and concierge services and wedding services are also offered.
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.49 mi from Louisville Science Center
$119 nightly
The price is $140 total per night
$140 total
Dec 17 - Dec 18
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and free perks like on-the-go breakfast and a roundtrip airport shuttle. Valet parking, a 24-hour business center, and free WiFi in public areas are also offered.
Omni Louisville Hotel

Omni Louisville Hotel

4 out of 5
400 S. 2nd Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.51 mi from Louisville Science Center
$167 nightly
The price is $197 total per night
$197 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
A full-service spa, 3 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Make the most of the 24-hour gym and hot tub, and relax with drinks at one of the 3 bars/lounges.
Hilton Garden Inn Louisville Downtown

Hilton Garden Inn Louisville Downtown

3.5 out of 5
350 West Chestnut Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.63 mi from Louisville Science Center
$95 nightly
The price is $112 total per night
$112 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. Self parking, a terrace, and a grocery/convenience store are also offered.
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

3 out of 5
120 SOUTH FLOYD ST Louisville KY
Free Cancellation
0.77 mi from Louisville Science Center
$79 nightly
The price is $93 total per night
$93 total
Dec 24 - Dec 25
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the 24-hour gym and conveniences like a 24-hour front desk and laundry facilities.
The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
Free Cancellation
Reserve now, pay when you stay
0.77 mi from Louisville Science Center
$118 nightly
The price is $139 total per night
$139 total
Dec 4 - Dec 5
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport shuttle. Valet parking, a coffee shop, and dry cleaning are also offered.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Louisville Science Center hotels essential information

Accommodation
1,884 hotels
Lowest Price
$90
Highest Price
$197
Popular hotels
Galt House Hotel Trademark Collection by Wyndham, Omni Louisville Hotel, Holiday Inn Express & Suites Louisville Downtown by IHG, Embassy Suites Louisville Downtown, The Grady, 21c Museum Hotel Louisville, Homewood Suites by Hilton Louisville Downtown, KY, Towneplace Suites By Marriott Louisville Downtown, Hyatt Regency Louisville, The Brown Hotel, Cambria Hotel Louisville Downtown-Whiskey Row, Hilton Garden Inn Louisville Downtown

Recent Louisville Science Center hotel reviews by fellow wanderers

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"Everything about our stay was great! Super clean. Friendly staff. Large room. "
A verified traveler stayed at Galt House Hotel Trademark Collection by Wyndham
Galt House Hotel Trademark Collection by Wyndham

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