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21c Museum Hotel Louisville

4.5 star property
Luxury hotel with a full-service spa and a 24-hour fitness center

Choose dates to view prices

Photo gallery for 21c Museum Hotel Louisville

Front of property
Interior
Bar (on property)
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Fountain

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Spa
  • Room service
  • Pet friendly

Explore the area

View in a map
700 W Main Street, Louisville, KY, 40202
  • Place, Louisville Slugger Museum
    ‪3 min walk‬
  • Place, Kentucky International Convention Center
    ‪8 min walk‬
  • Place, KFC Yum Center
    ‪8 min walk‬
  • Airport, Louisville, KY (SDF-Louisville Intl.)
    ‪9 min drive‬

Room options

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(29 reviews)
  • 335 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 435 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(65 reviews)
  • 350 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(30 reviews)
  • 455 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down comforters, minibar, in-room safe

Suite, Corner

  • 660 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down comforters, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

  • 434 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

  • 435 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

  • Sleeps 4
  • 1 Double Bed

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About the neighborhood

Louisville

Downtown Louisville stay.A stay at this Downtown Louisville hotel places you steps from Louisville Slugger Museum and within a 10-minute walk of KFC Yum Center. 21c Museum Hotel and Louisville Science Center are also within half a mile (1 km).

What's nearby

  • Muhammad Ali Center - 3 min walk - 0.2 miles
  • Louisville Slugger Museum - 3 min walk - 0.2 miles
  • Fourth Street Live! - 8 min walk - 0.4 miles
  • Kentucky International Convention Center - 8 min walk - 0.5 miles
  • KFC Yum Center - 8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Mussel & Burger Bar - ‬1 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Pokehana - ‬5 min walk

About this property

21c Museum Hotel Louisville

4.5-star luxury hotel near KFC Yum Center
21c Museum Hotel Louisville offers its guests a full-service spa and a 24-hour fitness center. There's a restaurant on site. You can enjoy a drink at the bar/lounge. A computer station is on site, and both WiFi and wired Internet are free in public spaces.

A 24-hour business center, meeting rooms, and limo/town car service are available. Event space at this hotel measures 5000 square feet (465 square meters) and includes conference space. Spa services, multilingual staff, and gift shops/newsstands are also featured at the luxury 21c Museum Hotel Louisville. Parking is available for a fee.

This 4.5-star Louisville hotel is smoke free.

  • 1 building
  • 91 guestrooms or units
  • 4 levels
  • Meeting rooms
  • 5000 sq ft of conference space
  • 465 sq m of conference space
  • Built in 2006
  • Charging station for electric cars
  • Business center (24 hours)
  • Conference space
  • Breakfast available (surcharge)
  • Coffee in lobby
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Staff is multilingual
  • Storage area for luggage
  • Front-desk safe
  • Car service
  • Tour and ticket information
  • Concierge
  • Gift shop
  • Newspapers in lobby (free)
  • ATM
  • Bellhop
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Dining venue
21c Museum Hotel Louisville offers 91 accommodations with iPod docking stations and minibars. Beds feature down comforters and premium bedding. 50-inch LCD televisions come with premium cable channels. Bathrooms include bathrobes, designer toiletries, complimentary toiletries, and hair dryers.

This Louisville hotel provides complimentary wired and wireless Internet access. Business-friendly amenities include desks and laptop-compatible safes; free local calls are provided (restrictions may apply). Additionally, rooms include espresso makers and complimentary bottled water. In-room massages, hypo-allergenic bedding, and change of towels can be requested. A nightly turndown service is provided and housekeeping is offered daily.

Guests can pamper themselves with a trip to the onsite spa, which has 2 treatment rooms. Services include massages.

Awards and affiliations

Eco-Certified Property
This property participates in Green Key Global, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

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Property amenities

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Daily full breakfast available for a fee: USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

Room amenities

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • Pets: USD 40.00 per accommodation, per stay
  • Weight limit: 50 lbs per pet
  • Food and water bowls are available
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are available for USD 30.0 per night.
  • Free cribs (infant beds)!

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5.00 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)
Charges for extra guests may apply and vary according to property policy.
A credit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation. This property accepts Visa, Mastercard, American Express, and Discover. Cash is not accepted. 
    For guests' safety, the property includes a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards in each accommodation. This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • Connecting/adjoining rooms are subject to availability and can be requested by contacting the property at the number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
21c Museum Hotel Louisville
21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
21c Museum Hotel Louisville MGallery
21c Museum Louisville MGallery
Hotel 21c Museum Hotel Louisville - MGallery Louisville
Louisville 21c Museum Hotel Louisville - MGallery Hotel
21c Museum Hotel Louisville - MGallery Louisville
Hotel 21c Museum Hotel Louisville - MGallery
21c Museum Hotel MGallery
21c Museum MGallery
21c Museum Hotel Louisville
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21c Museum Hotel Louisville Louisville
21c Museum Hotel Louisville Hotel Louisville

Frequently asked questions

How close is 21c Museum Hotel Louisville to the airport?

21c Museum Hotel Louisville is 7.1 mi (10-min drive) away from the Louisville Intl. Airport (SDF) airport, the closest popular airport to the property.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Oct 7, 2025, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Oct 31, 2025 start from $179.55, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does 21c Museum Hotel Louisville have an airport shuttle?

Airport shuttle services are not available at 21c Museum Hotel Louisville.

Does 21c Museum Hotel Louisville offer free breakfast?

Free breakfast isn’t provided at 21c Museum Hotel Louisville, but full breakfast is offered for a fee of between USD 5 and 25 per person.

Is there a casino at 21c Museum Hotel Louisville?

No, there is no casino at this hotel, but Horseshoe Southern Indiana Casino (22-min drive) is nearby.

What time is check-in at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight.

Is there free parking at 21c Museum Hotel Louisville?

Free parking is not available at this hotel. Valet parking is available for USD 32 per night.

Does 21c Museum Hotel Louisville have a pool?

21c Museum Hotel Louisville does not have a pool.

Does 21c Museum Hotel Louisville have a restaurant?

21c Museum Hotel Louisville is home to Proof on Main, which features light fare and brunch.

Does 21c Museum Hotel Louisville have a spa?

This hotel has a spa, which features massages.

How close is 21c Museum Hotel Louisville to downtown Louisville?

21c Museum Hotel Louisville is 0.4 mi away from Louisville.

Reviews

21c Museum Hotel Louisville Reviews

9.4

Exceptional

9.6/10

Cleanliness

9.4/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

9.2/10

Eco-friendliness
Rating 10 - Excellent. 766 out of 1004 reviews
Rating 8 - Good. 136 out of 1004 reviews
Rating 6 - Okay. 60 out of 1004 reviews
Rating 4 - Poor. 23 out of 1004 reviews
Rating 2 - Terrible. 19 out of 1004 reviews

Reviews

10/10 Excellent

Matt

Stayed 1 night in Jul 2025

10/10 Excellent

Monte

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

21c is Amazing

The hotel and the hotel staff were both excellent. We appreciated the friendliness of every staff member we encountered and the aesthetics of the entire hotel. Our room was very clean, comfortable, appealing and so quiet. We were very pleased with our stay.
Stayed 1 night in Jul 2025

10/10 Excellent

Michael, Austin

Was great
Stayed 4 nights in Jun 2025

10/10 Excellent

Britney

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Very cool hotel

Great hotel in the heart of the Bourbon Trail, loved the big rooms, art and the smiling door man.
Stayed 3 nights in Jun 2025

10/10 Excellent

Thomas, Dingley Village

Stayed 2 nights in Jun 2025

4/10 Poor

Valerie

Traveled with partner
Liked: Cleanliness
The walls were paper thin. Made the stay really uncomfortable. This is my second visit to this hotel, and the art this time around was very disappointing. No exciting installations at all. Location is great. Staff was friendly, I was just really under whelmed with the experience. I don't think I'll be back.
Stayed 2 nights in Jun 2025

10/10 Excellent

Megha

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Jun 2025

10/10 Excellent

Thomas, Bradenton

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent place to stay.
Stayed 1 night in Jun 2025

10/10 Excellent

Vanessa, Las Vegas

Liked: Cleanliness
Stayed 1 night in Jun 2025

10/10 Excellent

Sharon

Stayed 1 night in Jun 2025

10/10 Excellent

Gretchen

Liked: Cleanliness, staff & service, property conditions & facilities
.
Stayed 3 nights in Jun 2025

10/10 Excellent

Wilkins

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The property was awesome! Love the art display, the bar in the hotel had friendly staff. Close to everything
Stayed 3 nights in Jun 2025

10/10 Excellent

BING

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jun 2025

10/10 Excellent

Ilya

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great location, comfy beds, great service
Stayed 2 nights in Jun 2025

6/10 Okay

Tammy

Traveled with family
Liked: Cleanliness
3.8 Very industrial. Creepy wall art near rooms on 4th floor. Art museum was fun to explore.
Stayed 2 nights in Jun 2025

10/10 Excellent

anne delano

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was so incredibly helpful and pleasant.
Stayed 1 night in Jun 2025

10/10 Excellent

Kyle

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Super cool hotel - rooms are clean, modern, and large. Fun art makes it a great stay. There was an artist reception while we were there, so it truly was like a museum visit included with our hotel stay. We had a very nice dinner at the restaurant (Proof on Main). We did buy the breakfast, which basically was a coupon for that amount at the restaurant. No need to buy in advance, you might find something better elsewhere.
Stayed 1 night in Jun 2025

10/10 Excellent

Leigh

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Rooms are very quiet. Always very clean. The bed is very comfortable. Proof is always a great spot to dine or there are many other options in walking distance.
Stayed 1 night in Jun 2025

10/10 Excellent

Sally

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Jun 2025

10/10 Excellent

Rachel

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
All around great experience.
Stayed 3 nights in Jun 2025

10/10 Excellent

Teresa

Stayed 2 nights in Jun 2025

10/10 Excellent

Mark

Stayed 1 night in May 2025

10/10 Excellent

Don

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Excellent experience to be immersive museum in a luxury hotel.The restaurant was 5star though I did not ask to confirm. Being the Original and Founding Hotels.
Stayed 1 night in May 2025

10/10 Excellent

Han

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
We were able to check in early. Room is clean and breakfast is great.
Stayed 1 night in May 2025

10/10 Excellent

Casey

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Love this hotel and amenities
Stayed 1 night in May 2025